Ƙungiyar Tsakanin Kumburi na Gut, Tsufa, da Ciwon Cutar Alzheimer

A cikin 'yan shekarun nan, alaƙar da ke tsakanin ƙananan ƙwayoyin cuta da cututtukan ƙwayoyin cuta sun zama wurin bincike. Shaidu da yawa sun nuna cewa kumburin hanji (kamar leaky gut da dysbiosis) na iya shafar ci gaban cututtukan neurodegenerative, musamman cutar Alzheimer (AD), ta hanyar “gut-brain axis”. Wannan labarin yana nazarin yadda kumburin hanji ya karu tare da shekaru kuma yayi nazarin yiwuwar haɗin gwiwa tare da ilimin cututtuka na AD (kamar β-amyloid deposition da neuroinflammation), yana ba da sababbin ra'ayoyi don fara shiga AD.

1. Gabatarwa

Cutar Alzheimer (AD) ita ce mafi yawan cututtukan neurodegenerative, wanda ke da alamun β-amyloid (Aβ) plaques da hyperphosphorylated tau protein. Kodayake kwayoyin halitta (misali, APOE4) sune manyan abubuwan haɗari na AD, tasirin muhalli (misali, abinci, lafiyar gut) na iya taimakawa wajen ci gaban AD ta hanyar kumburi na kullum. Gut, a matsayin mafi girma na rigakafi na jiki, na iya rinjayar lafiyar kwakwalwa ta hanyoyi da yawa, musamman a lokacin tsufa.

2. Ciwon Gut da Tsufa

2.1 Rushewar shekaru masu alaƙa da aikin shingen hanji
Tare da shekaru, mutuncin shinge na hanji yana raguwa, yana haifar da "leaky gut", yana ba da damar ƙwayoyin ƙwayoyin cuta (irin su lipopolysaccharide, LPS) don shiga cikin jini, yana haifar da ƙananan ƙananan ƙwayoyin cuta. Nazarin ya nuna cewa bambance-bambancen flora na hanji a cikin tsofaffi yana raguwa, ƙwayoyin cuta masu kumburi (irin su Proteobacteria) suna karuwa, kuma ƙwayoyin cuta masu kumburi (irin su Bifidobacterium) suna raguwa, suna kara tsananta amsawar kumburi.

2.2 Abubuwa masu kumburi da tsufa
Ƙunƙarar ƙarancin ƙima na yau da kullun ("tsufa mai kumburi", kumburi) muhimmin fasalin tsufa ne. Abubuwan kumburin hanji (kamarIL-6, TNF-α) na iya shiga cikin kwakwalwa ta hanyar jini na jini, kunna microglia, inganta neuroinflammation, da kuma hanzarta tsarin tsarin pathological na AD.

da kuma inganta neuroinflammation, don haka accelerating AD Pathology.

3. Haɗin Kai Tsakanin Kumburi na Gut da Ciwon Cutar Alzheimer

3.1 Gut Dysbiosis da Aβ Deposition

Samfuran dabbobi sun nuna cewa rikicewar furen hanji na iya ƙara yawan Aβ. Misali, berayen da aka yi wa maganin rigakafi sun rage alamun Aβ, yayin da matakan Aβ suka karu a cikin mice tare da dysbiosis. Wasu metabolites na kwayan cuta (kamar gajeriyar sarkar fatty acids, SCFAs) na iya shafar sharewar Aβ ta hanyar daidaita aikin microglial.

3.2 Gut-Brain Axis da Neuroinflammation

Gut kumburi na iya shafar kwakwalwa ta hanyar vagal, tsarin rigakafi, da hanyoyin rayuwa:

• Hanyar Vagal: ana watsa siginar kumburin hanji ta hanyar jijiyar vagus zuwa CNS, yana shafar aikin hippocampal da prefrontal cortex.
• Kumburi na tsarin: Abubuwan ƙwayoyin cuta irin su LPS suna kunna microglia kuma suna haɓaka neuroinflammation, haɓaka tau Pathology da lalacewar neuronal.
• Tasirin Metabolic: Gut dysbiosis na iya shafar metabolism na tryptophan, yana haifar da rashin daidaituwa a cikin masu watsawa (misali, 5-HT) kuma yana shafar aikin fahimi.

3.3 Shaidar asibiti

• Marasa lafiya da ke da AD suna da banbancin nau'in flora na hanji fiye da tsofaffi masu lafiya, misali, rashin daidaituwa na phylum mai kauri/Antibacterial phylum.
• Matakan jini na LPS suna da alaƙa daidai da tsananin AD.
• Maganganun ƙwayoyin cuta (misali Bifidobacterium bifidum) yana rage ajiyar Aβ da haɓaka aikin fahimi a cikin ƙirar dabba.

4. Dabarun Matsalolin Mahimmanci

gyare-gyaren abinci: babban fiber, abinci na Rum na iya inganta haɓakar ƙwayoyin cuta masu amfani da rage kumburi.

1. Probiotics/Prebiotics: kari tare da takamaiman nau'ikan ƙwayoyin cuta (misali, Lactobacillus, Bifidobacterium) na iya haɓaka aikin shingen hanji.
2. Magungunan rigakafin kumburi: magungunan da ke yin niyya ga kumburin hanji (misali, masu hana TLR4) na iya rage ci gaban AD.
3. Shirye-shiryen salon rayuwa: motsa jiki da raguwar damuwa na iya kiyaye ma'auni na furen gut

5. Kammalawa da Halayen Gaba

Kumburi na gut yana ƙaruwa da shekaru kuma yana iya ba da gudummawa ga ilimin cututtuka na AD ta hanyar gut-brain axis. Nazarin gaba ya kamata ya ƙara fayyace alaƙar da ke haifar da ƙayyadaddun flora da AD da kuma bincika rigakafin AD da dabarun jiyya bisa ka'idar flora gut. Bincike a cikin wannan yanki na iya samar da sababbin maƙasudi don fara shiga cikin cututtukan neurodegenerative.

Likitan Xiamen Baysen Mu Baysen Likita koyaushe yana mai da hankali kan dabarun bincike don inganta ingancin rayuwa. Mun ɓullo da 5 fasahar dandamali- Latex, colloidal zinariya, Fluorescence Immunochromatographic Assay, Kwayoyin, Chemiluminescence Immunoassay. Muna mayar da hankali kan lafiyar hanji, da na mugwajin CAL ana amfani da shi don gano kumburi a cikin hanji.

Magana:

1. Vogt, NM, et al. (2017). "Gut microbiome canje-canje a cikin cutar Alzheimer."Rahoton Kimiyya.
2. Dodiya, HB, et al. (2020). "Kumburi na yau da kullun yana ƙara haɓaka tau Pathology a cikin ƙirar linzamin kwamfuta na cutar Alzheimer."Yanayin Neuroscience.
3. Franceschi, C., et al. (2018). "Kumburi: sabon ra'ayi na rigakafi-metabolic don cututtuka masu alaka da shekaru."Nature Reviews Endocrinology.