ʻO ka pilina ma waena o ka mumū o ka ʻōpū, ka ʻelemakule, a me ka maʻi Alzheimer

I nā makahiki i hala iho nei, ua lilo ka pilina ma waena o ka microbiota gut a me nā maʻi neurological i wahi noiʻi. Hōʻike ka nui o nā hōʻike e hiki i ka mumū ʻōpū (e like me ka leaky gut a me ka dysbiosis) ke hoʻopilikia i ka holomua o nā maʻi neurodegenerative, ʻoiai ka maʻi Alzheimer (AD), ma o ka "gut-brain axis". Hōʻike kēia ʻatikala pehea e hoʻonui ai ka mumū ʻōpū me ka makahiki a nānā i kona pilina hiki me ka pathology AD (e like me ka β-amyloid deposition a me ka neuroinflammation), e hāʻawi ana i nā manaʻo hou no ke komo mua ʻana o AD.

1. Hoʻolauna

ʻO ka maʻi Alzheimer (AD) ka maʻi neurodegenerative maʻamau, i hōʻike ʻia e nā plaques β-amyloid (Aβ) a me ka protein tau hyperphosphorylated. ʻOiai ʻo nā mea hoʻoilina (e laʻa, APOE4) nā mea nui e pilikia ai ka AD, hiki i nā mana o ke kaiapuni (e laʻa, ka ʻai, ke olakino o ka ʻōpū) ke kōkua i ka holomua o ka AD ma o ka mumū mau. ʻO ka ʻōpū, ma ke ʻano he ʻōkana pale kino nui loa o ke kino, hiki ke hoʻopili i ke olakino o ka lolo ma o nā ala he nui, ʻoi aku hoʻi i ka wā ʻelemakule.

2. Ka mumū ʻōpū a me ka ʻelemakule

2.1 Ka emi ʻana o ka hana pale ʻōpū e pili ana i ka makahiki
Me ka ʻelemakule, emi iho ka pono o ka pale ʻōpū, e alakaʻi ana i ka "leaky gut", e ʻae ana i nā metabolites bacteria (e like me lipopolysaccharide, LPS) e komo i ke kahe koko, e hoʻoulu ai i ka mumū haʻahaʻa systemic. Ua hōʻike ʻia nā haʻawina e emi ana ka ʻokoʻa o nā flora ʻōpū i ka poʻe ʻelemakule, piʻi ka bacteria pro-inflammatory (e like me Proteobacteria), a emi iho ka bacteria anti-inflammatory (e like me Bifidobacterium), e hoʻonui hou aku ana i ka pane mumū.

2.2 Nā mea hoʻonāukiuki a me ka ʻelemakule
ʻO ka mumū haʻahaʻa mau loa ("ka ʻelemakule mumū", Inflammaging) he hiʻohiʻona koʻikoʻi o ka ʻelemakule. Nā mea mumū o ka ʻōpū (e like meIL-6, TNF-α) ke komo i loko o ka lolo ma o ke kahe koko, hoʻoulu i ka microglia, paipai i ka neuroinflammation, a hoʻolalelale i ke kaʻina hana pathological o AD.

a me ka hoʻolaha ʻana i ka neuroinflammation, no laila e hoʻolalelale ai i ka pathology AD.

3. ʻO ka loulou ma waena o ka mumū o ka ʻōpū a me ka maʻi Alzheimer

3.1 ʻO ka Dysbiosis Gut a me ka waiho ʻana o Aβ

Ua hōʻike ʻia nā hiʻohiʻona holoholona e hiki i ka hoʻopilikia ʻana o ka flora ʻōpū ke hoʻonui i ka waiho ʻana o Aβ. No ka laʻana, ua hōʻemi nā ʻiole i mālama ʻia me nā antibiotic i nā plaques Aβ, ʻoiai ua hoʻonui ʻia nā pae Aβ i nā ʻiole me ka dysbiosis. Hiki i kekahi mau metabolites bacteria (e like me nā waikawa momona kaulahao pōkole, SCFAs) ke hoʻopilikia i ka hoʻomaʻemaʻe ʻana o Aβ ma o ka hoʻoponopono ʻana i ka hana microglial.

3.2 ʻO ke Axis Gut-Brain a me Neuroinflammation

Hiki i ka mumū o ka ʻōpū ke hoʻopilikia i ka lolo ma o ka vagal, ka ʻōnaehana pale, a me nā ala metabolic:

• Ke ala Vagal: hoʻouna ʻia nā hōʻailona mumū ʻōpū ma o ke aʻalolo vagus i ka CNS, e hoʻopilikia ana i ka hana hippocampal a me ka prefrontal cortex.
• ʻŌnaehana mumū: Hoʻoulu nā ʻāpana bacteria e like me LPS i ka microglia a paipai i ka neuroinflammation, e hoʻonui ana i ka pathology tau a me ka hōʻino neuronal.
• Nā hopena metabolic: hiki i ka gut dysbiosis ke hoʻopilikia i ka metabolism tryptophan, e alakaʻi ana i nā kaulike ʻole i nā neurotransmitters (e laʻa, 5-HT) a me ka hoʻopilikia ʻana i ka hana cognitive.

3.3 Nā Hōʻike Lapaʻau

• He ʻokoʻa loa ka haku mele ʻana o nā flora ʻōpū o nā maʻi me AD ma mua o nā pākeke olakino, e laʻa, he lakio ʻē aʻe o ka phylum Thick-walled/Antibacterial phylum.
• He pilina maikaʻi nā pae koko o LPS me ke koʻikoʻi o AD.
• Hoʻemi nā hana probiotic (e laʻa me Bifidobacterium bifidum) i ka waiho ʻana o Aβ a hoʻomaikaʻi i ka hana noʻonoʻo i nā hiʻohiʻona holoholona.

4. Nā Hoʻolālā Hana Komo Hiki

Nā hoʻololi ʻana i ka meaʻai: hiki i ka meaʻai Mediterranean kiʻekiʻe-fiber ke hoʻoulu i ka ulu ʻana o nā bacteria maikaʻi a hōʻemi i ka mumū.

1. Probiotics/Prebiotics: ʻo ka hoʻopihapiha ʻana me nā ʻano bacteria kikoʻī (e like me Lactobacillus, Bifidobacterium) e hoʻomaikaʻi i ka hana pale ʻōpū.
2. Nā lāʻau lapaʻau anti-inflammatory: nā lāʻau lapaʻau e kuhikuhi ana i ka mumū o ka ʻōpū (e like me nā mea hoʻopaʻa TLR4) hiki ke hoʻolohi i ka holomua o AD.
3. Nā hana hoʻoponopono nohona: hiki i ka hoʻoikaika kino a me ka hoʻemi ʻana i ke kaumaha ke mālama i ke kaulike o ka flora gut

5. Hopena a me nā Manaʻo no ka Wā e Hiki Mai Ana

Hoʻonui ka mumū o ka ʻōpū me ka makahiki a hiki ke kōkua i ka pathology AD ma o ke axis gut-brain. Pono nā haʻawina e hiki mai ana e hoʻomālamalama hou aku i ka pilina kumu ma waena o nā flora kikoʻī a me AD a e ʻimi i nā hoʻolālā pale a me ka mālama ʻana iā AD e pili ana i ka hoʻoponopono ʻana i ka flora gut. Hiki i ka noiʻi ma kēia wahi ke hāʻawi i nā pahuhopu hou no ke komo mua ʻana i nā maʻi neurodegenerative.

ʻO Xiamen Baysen Medical ʻO mākou ʻo Baysen Medical ke kālele mau nei i ke ʻano hana diagnostic e hoʻomaikaʻi i ke ʻano o ke ola. Ua hoʻomohala mākou i 5 mau kahua ʻenehana- Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Ke kālele nei mākou i ke olakino o ka ʻōpū, a me kā mākouHoʻāʻo CAL hoʻohana ʻia e ʻike i ka mumū i loko o ka ʻōpū.

Nā Kuhikuhi:

1. ʻO Vogt, NM, et al. (2017). "Nā hoʻololi ʻana o ka microbiome o ka ʻōpū i ka maʻi o Alzheimer."Nā Hōʻike ʻEpekema.
2. ʻO Dodiya, HB, et al. (2020). "Hoʻonui ka mumū mau o ka ʻōpū i ka pathology tau i loko o kahi kumu hoʻohālike ʻiole o ka maʻi Alzheimer."ʻEpekema Neurolo kūlohelohe.
3. ʻO Franceschi, C., et al. (2018). "Ka mumū: kahi manaʻo hou no ka pale ʻana i ka maʻi me ka metabolic no nā maʻi e pili ana i ka ʻelemakule."Nā Loiloi Kūlohelohe Endocrinology.