Ka pilina ma waena o ka momona momona a me Insulin

ʻO ka pilina ma waena o Fatty Liver a me Glycated Insulin he pilina pili loa ma waena o ka momona momona (ʻoi aku ka maʻi o ka momona momona ʻole, NAFLD) ainsulin(a i ʻoleinsulinkū'ē, hyperinsulinemia), ka mea i hoʻopili mua ʻia ma o nā maʻi metabolic (e laʻa, ka momona, ʻano 2diabetes,etc.). Eia ka wehewehe kikoʻī o nā mea nui:


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1. InsulinKū'ē e like me ka Mechanism Core

  • InsulinʻO ke kū'ē (IR) kahi kumu pathological maʻamau no ka momona o ka ate a me ka metabolism glucose maʻamau. Ke emi iho ka naʻau o ke kino i ka insulin, ʻoi aku ka nui o ka huna ʻana o ka pancreasinsulin(hyperinsulinemia), ka hopena o ke kiʻekiʻe o ka insulin koko.
  • Nā hopena o ka momona momona: hepaticinsulinpale ka pale ʻana i ka momona momona, hoʻoikaika i ka synthesis momona (lipid deposition), a hoʻonui i ka hōʻiliʻili ʻana o ka momona i nā hepatocytes (steatosis).
  • Hui meHbA1c: ʻOiai ʻaʻole hoʻohana maʻamau ka insulin glycated, hoʻonui ka hyperglycemia lōʻihi (pili ʻia me IR) i ka hemoglobin glycated.(HbA1c), e noʻonoʻo ana i ka maikaʻi ʻole o ke kōpaʻa koko, e pili ana i ka piʻi ʻana o ka momona momona i ka steatohepatitis non-alcoholic (NASH).

2. Hoʻoikaika ka Hyperinsulinemia i ka maʻi ʻaʻai momona

  • Ka hana pololei: Hoʻoikaika ka Hyperinsulinemia i ka lipogenesis hepatic (↑ lipid synthesis) ma o ka hoʻōla ʻana i nā mea transcription (eg SREBP-1c) ʻoiai ke kāohi nei i ka momona momona β-oxidation.
  • Ka hopena ʻole:InsulinʻO ke kū'ē ke kumu e hoʻokuʻu ai ka ʻiʻo adipose i nā ʻakika momona manuahi (FFAs), i komo i loko o ke ake a hoʻololi ʻia i triglycerides, e hoʻomāhuahua hou aʻe i ka momona momona.

3. ʻO ka momona momona e hoʻonui i ka metabolism glucose abnormal

  • Hoʻokomo ʻia i ke akepaʻaInsulinKū'ē: Hoʻokuʻu ke ake momona i nā cytokine inflammatory (e laʻa, TNF-α,IL-6) a me nā adipokines (e laʻa, ka pale ʻana i ka leptin, hoʻemi ʻia ka adiponectin), e hoʻomāhuahua ana i ka ʻōnaehana insulin.
  • Hoʻonui ka hoʻonui ʻana i ka glucose hepatic:insulinʻO ke kū'ē ka hopena i ka hiki ʻole i ke ake ke hoʻopaʻa pono i ka gluconeogenesis, a ʻo ka hoʻokē ʻai ʻana i ke koko koko e hoʻomāhuahua hou aʻe i ka metabolism glucose (hiki ke piʻi i ka maʻi diabetes type 2).

4. Hōʻike hōʻike lapaʻau:Hemoglobin Glycosylated (HbA1c)a me ka momona momona

  • ʻO ka HbA1c kiʻekiʻe e wānana i ka pilikia o ka ate: ua hōʻike ʻia kekahi mau haʻawinaHbA1cHoʻopili maikaʻi ʻia nā pae me ka paʻakikī o ke akepaʻa momona, ʻoiai inā ʻaʻole i hoʻokō ʻia nā koina diagnostic diabetes (piʻi nui ʻia ka pilikia me ka HbA1c ≥ 5.7%).
  • ʻO ka Mana Glycemic i nā maʻi ʻaʻai momona: ʻO nā poʻe maʻi maʻi maʻi me ka momona momona e koi aku i ka hoʻokele koʻikoʻi o ke kō koko (nā pahu HbA1c haʻahaʻa) e hoʻolōʻihi i ka piʻi ʻana o ka maʻi ate.

5. Nā Kūlana Kūlana: HoʻomaikaʻiInsulinʻO ka ʻike

  • Nā hoʻololi ʻana i ke ʻano o ke ola: hoʻemi ke kaumaha (5-10% ʻoi aku ka maikaʻi o ke kaumaha o ke kaumaha o ka momona), ka ʻai haʻahaʻa-carbohydrate/momona momona, hoʻoikaika kino.
  • Nā lāʻau lapaʻau:
    • InsulinsHiki i nā ensitizers (eg, metformin, pioglitazone) ke hoʻomaikaʻi i ka momona momona a me ka metabolism glucose.
    • ʻO nā agonists loaʻa GLP-1 (e laʻa, liraglutide, semaglutide) kōkua i ka pohō kaumaha, ka mālama glycemic, a me ka hōʻemi ʻana i ka momona.
  • Nānā: hoʻokēʻaiinsulin, HOMA-IR (insulin resistance index), HbA1c a me ka ate imaging/elastography i hoao mau.

Ka hopena

ʻO ke akepaʻa momona a insulin (a i ʻole hyperinsulinemia) e hana i kahi pōʻai ʻino ma o ke kū ʻana o ka insulin. ʻO ke komo mua ʻana oinsulinhoʻomaikaʻi ka pale ʻana i ka momona momona a me ka metabolism glucose a hoʻemi i ka pilikia o ka maʻi diabetes a me ka fibrosis ate. Pono e loiloi pū ʻia nā māka metabolic ma ke keʻena ma mua o ka nānā ʻana i hoʻokahi hōʻailona wale nō.

Ke nānā mau nei mākou ʻo Baysen Medical i ka ʻenehana diagnostic e hoʻomaikaʻi i ka maikaʻi o ke ola. Ua hoʻomohala mākou i nā ʻenehana ʻenehana 5- Latex, colloidal gula, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, kā mākouHōʻike HbA1c,Hoʻāʻo insulinaHoʻāʻo C-peptide hana maʻalahi a hiki ke loaʻa ka hopena hōʻike ma 15 mins

 

 


Ka manawa hoʻouna: Jul-09-2025