Ka Hoʻāʻo Hoʻāʻo ʻAʻole Invasive:ʻO Calprotectin Fecal"Keʻa i nā Palena" e Kōkua i ka ʻIke mua ʻana o ka mumū o ka GI kiʻekiʻe i nā keiki

Ma ke kahua o ka ʻike ʻana i nā maʻi o ka ʻōnaehana digestive pediatric, ua lōʻihi ka endoscopy i "kūlana gula" no ka hoʻoholo ʻana i ka mumū o ka ʻōpū o luna. Eia nō naʻe, ʻaʻole wale kēia hoʻokolokolo invasive i hele pū ʻia me ka ʻoluʻolu ʻole o ke kino no nā keiki, ʻoi aku hoʻi nā ʻōpio, akā lawe pinepine pū kekahi i ka makaʻu noʻonoʻo nui a me ka paʻakikī i ka hana pū ʻana. Hoʻolilo kēia i nā mākua he nui i ka kānalua i ka wā o ka ʻike mua ʻana a hiki ke nalowale i ka manawa kūpono no ke komo mua ʻana. I kēia manawa, ua lawe mai kahi noiʻi lapaʻau hou a me ka hana noi i nā nūhou hoihoi:ka calprotectin fecal (FCP), he hōʻailona makua ʻaʻole invasive no ka loiloi ʻana i nā maʻi gastrointestinal haʻahaʻa, ke hōʻike nei i ka hiki nui i ka ʻike mua ʻana o ka mumū gastrointestinal kiʻekiʻe i nā keiki, e hoʻokō ana i kahi "crossover" kupaianaha mai ka "ʻōpū haʻahaʻa" a i ka "ʻōpū kiʻekiʻe".

Mai ka Dilemma o ke "Gold Standard" a hiki i ka wanaʻao o ka hoʻāʻo ʻole-Invasive

ʻAʻole maʻamau nā mumū o ka ʻōpū o luna e like me ka gastritis a me ka gastroduodenitis i nā keiki, a ʻo ko lākou mau kumu e pili ana i ka maʻi, nā lāʻau lapaʻau, a me nā hopena o ke kaumaha. ʻO ka mea maʻamau, pono ka nānā ʻana i ka maka a me ka biopsy ʻiʻo ma o ka gastroscopy, he hana paʻakikī a komo i loko. ʻO nā ʻano ʻike ʻole-invasive a maʻalahi hoʻi ka mea maʻamau i manaʻo ʻia e nā kauka a me nā ʻohana o nā keiki me ka maʻi.ʻO ka calprotectin fecalhe protein e hōʻike ana i ka hōʻuluʻulu ʻana o ka neutrophil. Ke pehu ka mucosa gastrointestinal, e piʻi nui kona nui. I nā makahiki i hala iho nei, ua hoʻohana nui ʻia ia i ka loiloi hana o ka maʻi ʻōpū mumū (IBD) a me ka ʻike ʻokoʻa o ka maʻi ʻōpū huhū (IBS), ʻo ia hoʻi no ka pehu ʻana o ka colon.

Ua hōʻoia ka noiʻi ʻepekema i kahi kumu paʻa no nā noi "cross-border"

Ke hōʻike nei kahi kino noiʻi e ulu ana ʻaʻole kēia māka mumū i ka colon wale nō. Ke hana ʻia ka mumū ikaika ma ke ala gastrointestinal luna (e like me ka ʻōpū a me ka duodenum), komo pū nā hunaola mumū a hoʻokuʻu.kalprotectin. Hele kēia protein i lalo o ke ala ʻai me nā wai ʻai a me nā koena meaʻai, a laila ʻike ʻia i loko o ka ʻōpala. Ua hōʻike ʻia nā haʻawina hou i nā keikikalprotectin fecalʻOi aku ke kiʻekiʻe o nā pae i nā keiki me ka gastritis a i ʻole duodenitis i hōʻoia ʻia e ka endoscopically i hoʻohālikelike ʻia me ka poʻe me ka dyspepsia hana a i ʻole nā ​​​​​​mea i loaʻa i ka endoscopic maʻamau. ʻOiai ʻo nā pae FC kiʻekiʻe i hoʻokumu ʻia e ka mumū o ka gastrointestinal kiʻekiʻe he haʻahaʻa ma mua o nā mea i loko o ka IBD hana, ua hōʻike lākou i nā ʻokoʻa koʻikoʻi i hoʻohālikelike ʻia me nā poʻe olakino. Hōʻike kēia e hiki ke hoʻohana ʻia ka hoʻāʻo ʻana o FC ma ke ʻano he mea hana loiloi kūpono e kōkua i nā kauka e ʻike mua i nā keiki i ka pilikia kiʻekiʻe o ka mumū o ka gastrointestinal luna organik i waena o ka nui o nā keiki e hōʻike ana me nā hōʻailona e like me ka ʻeha o ka ʻōpū, ka pehu ʻana, a me ka nausea.

Ka Waiwai Lapaʻau: Ke Kūkulu ʻana i kahi Ala Diagnostic Pediatric Maikaʻi

ʻO ka noi palena ʻāina okalprotectin fecalua lawe mai i nā pono he nui i ka ʻike ʻana a me ka mālama ʻana i nā maʻi gastrointestinal kiʻekiʻe i nā keiki:

1. ʻAʻole komo a me ka hoʻokō kiʻekiʻe: He liʻiliʻi wale nō o ka hāpana ʻōpala e pono ai, a ʻo ke kaʻina hana he mea komo ʻole loa ia, kahi e hōʻemi nui ai i ke kaumaha kino a me ka noʻonoʻo ma luna o nā keiki. Ke ʻae nui nei nā mākua i ke kaʻina hana, e maʻalahi ai ka nānā koke ʻana i nā keʻena lapaʻau ma waho.
2. Mea hana loiloi a me ka triage kūpono: No nā keiki me nā hōʻailona gastrointestinal mau,ʻO Calprotectin Fecalhiki ke hana mua ʻia ka hoʻāʻo ʻana e hoʻokaʻawale pono ma waena o nā maʻi mumū a me nā maʻi hana. InāʻO ka calprotectin fecalhe maʻamau nā pae, hiki ke hoʻonohonoho mua ʻia nā mea hana a i ʻole hiki ke hoʻohana ʻia ka mālama ʻana a me ka nānā ʻana. Inā kiʻekiʻe nā pae FC, hāʻawi ia i kahi kumu ikaika no ka gastroscopy invasive, e pale ana i nā kaʻina hana endoscopic pono ʻole a me ka hoʻonui ʻana i ka hoʻokaʻawale ʻana o nā kumuwaiwai lapaʻau.
3. Kōkua i ka loiloi ʻana o ka pono a me ka hoʻi hou ʻana: Ma hope o ka ʻike ʻana i ka mumū o ka ʻōpū o luna a me ka hoʻomaka ʻana o ka lāʻau lapaʻau, ka nānā ʻana i nā loli i lokoʻO Calprotectin Fecalhiki i nā pae ke lawelawe ma ke ʻano he hōʻailona kuhikuhi no ka loiloi ʻana inā ua emi ka mumū a inā he pono ka lāʻau. Hiki iā ia ke kōkua i ka ʻike mua ʻana i ka hoʻi hou ʻana o ka maʻi.

Nānā i ka Wā e Hiki Mai Ana

ʻOiaʻiʻo, ʻo ka hoʻopili ʻana o ka fecal calprotectin i loko o ke ala gastrointestinal kiʻekiʻe e pono ai ka noiʻi hou aku e wehewehe pono i kona waiwai cutoff kūpono a kāpae i nā mea ʻē aʻe o ka gastrointestinal haʻahaʻa e hiki ai ke hoʻonui i ka FC. Eia nō naʻe, ma ke ʻano he ʻano pale palekana, maʻalahi, a me ke kumu kūʻai haʻahaʻa, wehe ia i kahi puka hou no ka ʻike mua ʻana o ka mumū gastrointestinal kiʻekiʻe i nā keiki. He hōʻailona ia i kahi ʻanuʻu i mua i ka ʻike ʻana i nā maʻi ʻōpū pediatric i kahi ala ʻoi aku ka lokomaikaʻi a me ka pololei. Manaʻo mākou me ka hoʻomau ʻana o ka noiʻi hohonu a me ka ʻike lapaʻau i hōʻiliʻili ʻia,kalprotectin fecal,e hoʻokani kēia "hōkū kea," i kahi kuleana koʻikoʻi i ka pale ʻana i ke olakino ʻōpū o nā keiki.

Ke nānā mau nei ʻo Baysen Medical i ke ʻano hana diagnostic e hoʻomaikaʻi i ke ʻano o ke ola. Ua hoʻomohala mākou i 5 mau kahua ʻenehana- Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Loaʻa iā mākou ke Colloidal Gold.ʻO ka calprotectin fecal pahu hoʻāʻo a me ka Fluorescence ImmunoassayPahu hoʻāʻo Calprotectinno ka hoʻāʻo ʻana