ʻO Calprotectin FecalHe Mea Hana Koʻikoʻi no ka ʻIke ʻokoʻa o nā Maʻi Gastrointestinal Haʻahaʻa

I ka hana lapaʻau, ʻo ka ʻike ʻana i nā maʻi gastrointestinal haʻahaʻa he pinepine ka pilikia, no ka mea, he nui nā maʻi (e like me ka maʻi ʻōpū mumū, ka maʻi ʻōpū huhū, a me ka infectious enteritis) he mau hōʻailona like ʻole, e paʻakikī ai ka hoʻokaʻawale pololei ʻana ma muli wale nō o nā hōʻike lapaʻau a me nā hoʻokolohua maʻamau.ʻO ka calprotectin fecal (FC), kahi biomarker ikaika ʻole, ʻaʻole invasive, ua hōʻike i ka waiwai nui i ka ʻike ʻokoʻa o nā maʻi gastrointestinal haʻahaʻa i nā makahiki i hala iho nei, e lilo ana i mea hana pono e kōkua i ka hoʻoholo ʻana i nā hoʻoholo lapaʻau.

He aha ka mea ʻO Calprotectin Fecal?

ʻO Calprotectin he protein i loaʻa i loko o ka cytoplasm o nā neutrophils. Ke loaʻa ka mumū o ka ʻōpū, neʻe nā neutrophils i ka mucosa ʻōpū a hoʻokuʻu i ka calprotectin, e alakaʻi ana i ka hoʻonui nui ʻia o kona nui i loko o nā feces. Ma muli o kona kūpaʻa kiʻekiʻe a me ka maʻalahi o ka ʻike ʻana, hōʻike maikaʻi ʻo FC i ke kiʻekiʻe o ka mumū o ka ʻōpū, e kōkua ana i ka hoʻokaʻawale ʻana ma waena o nā maʻi mumū o ka ʻōpū (e laʻa, IBD) a me nā kūlana ʻaʻole mumū (e laʻa, IBS).

Nā noi ma ka ʻike ʻokoʻa

1. Ka ʻokoʻa ma waena o ka maʻi ʻōpū mumū (IBD) a me ka maʻi ʻeha huhū (IBS)
   ʻO IBD (me ka maʻi Crohn a me ka ulcerative colitis) he maʻi mumū ʻōpū mau loa, ʻoiai ʻo IBS he maʻi hana me ka ʻole o nā ʻeha organik. Hoʻokiʻekiʻe pinepine ʻia nā pae FC i nā poʻe maʻi IBD (ʻoi aku ka nui ma mua o 100 μg/g), ʻoiai ʻo ka poʻe ma IBS aia ma loko o ka pae maʻamau (ʻoi aku ma mua o 50 μg/g). No laila, hiki i ka hoʻāʻo ʻana o FC ke lawelawe ma ke ʻano he mea hana nānā mua, e hōʻemi ana i nā kaʻina hana endoscopic pono ʻole, e hoʻohaʻahaʻa ana i nā kumukūʻai mālama ola, a me ka hoʻomaikaʻi ʻana i ka pono diagnostic.
2. Ka loiloi ʻana o ka hana maʻi IBD

Pili maikaʻi nā pae FC me ka hana maʻi ma IBD. Kōkua ka nānā mau ʻana i ka FC i ka loiloi ʻana i ka pono o ka lāʻau a wānana i ka hoʻi hou ʻana. No ka laʻana, ʻo ka emi ʻana o ka FC i ka wā o ka lāʻau e hōʻike ana i ka mumū i kāohi ʻia, ʻoiai ʻo ka piʻi hou ʻana e hōʻike ana i ka hoʻi hou ʻana o ka maʻi, e alakaʻi ana i nā hoʻoponopono i nā hoʻolālā lapaʻau.

3. Ka hoʻokaʻawale ʻana o ka enteritis infectious mai nā maʻi mumū ʻē aʻe

Hiki i ka enteritis infectious (e like me ka bacterial a viral enteritis) ke hoʻoulu i ka FC kiʻekiʻe, akā ʻoi aku ka haʻahaʻa o nā pae ma mua o nā mea ma IBD a emi koke i ka wā e hoʻopau ai ka maʻi. Kōkua ka nānā ʻana i ka FC i ka hoʻokaʻawale ʻana i nā maʻi transient mai nā maʻi mumū mau.

4. Nānā kōkua no ke Kanesa Colorectal

ʻOiai ʻaʻole ʻo FC kahi māka kikoʻī no ka maʻi ʻaʻai colorectal, pili pinepine nā ʻōpū ʻōpū i nā hopena mumū kūloko, e alakaʻi ana i nā piʻi iki a me ke kaulike o FC. Ke hui pū ʻia me nā hoʻokolohua ʻē aʻe (e laʻa, colonoscopy), hiki i ka FC ke hāʻawi i nā ʻike diagnostic hou aʻe.

Nā Pōmaikaʻi a me nā Palena

Ka hoʻāʻo ʻana o ka Fecal Calprotectin hāʻawi i nā pono e like me ka non-invasiveness, ka maʻalahi o ka hoʻohana ʻana, a me ke kumukūʻai haʻahaʻa, e kūpono ai no ka nānā mua ʻana a me ka nānā ʻana i ka wā lōʻihi. Eia nō naʻe, hoʻokiʻekiʻe ʻiaKaloka Fecal ʻaʻole ia he mea kūikawā i ka IBD a hiki ke ʻike ʻia i nā kūlana ʻē aʻe (e like me nā maʻi ʻōpū, nā puʻupuʻu, a me ka enteropathy pili i ka lāʻau anti-inflammatory nonsteroidal). No laila, pono kahi loiloi piha e pili ana i nā hōʻike lapaʻau, nā hoʻokolohua endoscopic, a me nā haʻawina kiʻi.

Hopena

ʻO ka calprotectin fecal Hāʻawi ka hoʻāʻo ʻana i kahi kumu koʻikoʻi no ka ʻike ʻokoʻa o nā maʻi gastrointestinal haʻahaʻa, e kōkua nui ana i ka hoʻokaʻawale ʻana iā IBD mai IBS a hoʻomaikaʻi i ka ʻike a me ka mālama ʻana. Me nā holomua i ka ʻenehana hoʻāʻo a me nā noi lapaʻau hohonu,kalprotectin fecal e pāʻani i kahi kuleana nui i ka mālama ʻana i nā maʻi gastrointestinal, e hāʻawi ana i nā mea maʻi me ka ʻike a me ka mālama ʻana me ka pololei a me ka maikaʻi.

Ma ka hoʻohana ʻana i ka ʻepekemakalprotectin fecalma ke ʻano he mea hana, hiki iā mākou ke lawelawe maikaʻi aku i ka hōʻoia lapaʻau a kōkua i ka hoʻokele a me ka mālama ʻana i nā maʻi gastrointestinal haʻahaʻa.

Lapaʻau ʻo Baysenke nānā mau nei i ke ʻano hana diagnostic e hoʻomaikaʻi i ke ʻano o ke ola. Ua hoʻomohala mākou i 5 mau kahua ʻenehana- Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Loaʻa iā mākou Hoʻāʻo wikiwiki ʻo Calprotectina meʻO wauhoʻāʻo Calprotectin mmunoassay no ka nānā ʻana i nā ʻeha puʻupaʻa i ke kahua mua.