ʻO ka maʻi hanu koʻikoʻi nui coronavirus 2 (SARS-CoV-2), ke kumu o ka maʻi ahulau coronavirus 2019 (COVID-19) hou loa, he maʻi RNA kaula hoʻokahi me ka nui o ka genome ma kahi o 30 kb. Ua puka mai nā ʻano like ʻole o SARS-CoV-2 me nā pūlima mutational ʻokoʻa i loko o ka maʻi ahulau. Ma muli o ko lākou ʻano mutational protein spike, ua hōʻike kekahi mau ʻano like ʻole i ka transmissibility kiʻekiʻe, ka infectivity, a me ka virulence.

ʻO ka moʻokūʻauhau BA.2.86 o SARS-CoV-2, i ʻike mua ʻia i ʻAukake 2023, he ʻokoʻa phylogeny ia mai nā moʻokūʻauhau Omicron XBB e kaʻapuni nei i kēia manawa, me EG.5.1 a me HK.3. Loaʻa i ka moʻokūʻauhau BA.2.86 ma mua o 30 mau mutations i loko o ka spike protein, e hōʻike ana he hiki loa i kēia moʻokūʻauhau ke pale aku i ka pale ʻana o ka maʻi anti-SARS-CoV-2 i loaʻa mua.

ʻO ka JN.1 (BA.2.86.1.1) ka ʻano hou loa i puka mai o SARS-CoV-2 i iho mai ka moʻokūʻauhau BA.2.86. Loaʻa i ka JN.1 kahi mutation L455S i loko o ka protein spike a me ʻekolu mau mutations ʻē aʻe i loko o nā protein non-spike. Ua hōʻike nā haʻawina e noiʻi ana iā HK.3 a me nā ʻano "FLip" ʻē aʻe e pili ana ka loaʻa ʻana o ka mutation L455F i loko o ka protein spike me ka hoʻonui ʻia o ka hiki ke hoʻoili i ka viral a me ka hiki ke pale aku i ka pale ʻana. Ua kapa ʻia nā mutations L455F a me F456L ʻo ""Flip"nā hoʻololi ʻana no ka mea ke hoʻololi nei lākou i nā kūlana o ʻelua mau waikawa amino, i kapa ʻia ʻo F a me L, ma ka protein spike.

Hiki iā mākou ʻo Baysen Medical ke hoʻolako i ka hoʻāʻo ponoʻī covid-19 no ka hoʻohana ʻana ma ka home, e ʻoluʻolu e hoʻokaʻaʻike mai iā mākou no nā kikoʻī hou aku.