ʻO ka C-Reactive Protein (CRP) kahi protein i hana ʻia e ke akepaʻa, a piʻi nui kona pae i loko o ke koko i ka pane ʻana i ka mumū. ʻO kona ʻike ʻia ʻana i ka makahiki 1930 a me nā noiʻi ma hope mai ua hoʻopaʻa i kona kuleana ma ke ʻano he hoʻokahi o nā biomarkers koʻikoʻi a hoʻohana nui ʻia i ka lāʻau lapaʻau hou. ʻO ke koʻikoʻi o ka hoʻāʻo ʻana o CRP aia i kona pono ma ke ʻano he hōʻailona koʻikoʻi, ʻoiai ʻaʻole kikoʻī, o ka mumū, e kōkua ana i ka ʻike ʻana, ka hoʻokaʻawale ʻana i nā pilikia, a me ka nānā ʻana i nā ʻano maʻi like ʻole.

1. He Mākaʻikaʻi no ka Maʻi a me ka Mumū
ʻO kekahi o nā hoʻohana nui o CRP ʻo ia ka ʻike ʻana a me ka hoʻokele ʻana i nā maʻi, ʻoiai nā maʻi bacteria. ʻOiai ʻo ka piʻi ʻana o ka CRP he pane maʻamau i ka mumū, hiki i nā pae ke piʻi nui i nā maʻi bacteria koʻikoʻi, ʻoi aku ka nui ma mua o 100 mg/L. ʻO kēia ka mea waiwai nui i ka hoʻokaʻawale ʻana i ka bacteria mai nā maʻi viral, ʻoiai ʻo ka mea hope loa ke kumu o ka piʻi ʻana o kahi kiʻekiʻe haʻahaʻa. Ma nā hoʻonohonoho lapaʻau, hoʻohana ʻia ʻo CRP e ʻike i nā kūlana e like me ka pneumonia, sepsis, a me nā maʻi ma hope o ke ʻoki ʻana. No ka laʻana, ʻo ka nānā ʻana i nā pae CRP ma hope o ke ʻoki ʻana e kōkua i nā kauka e ʻike i nā pilikia e like me nā maʻi ʻeha a i ʻole nā ​​abscesses hohonu i ka wā mua, e ʻae ana i ke komo koke ʻana. He mea nui nō hoʻi ia i ka hoʻokele ʻana i nā maʻi mumū mau e like me ka rheumatoid arthritis a me ka maʻi ʻōpū mumū (IBD), kahi e kōkua ai nā ana serial i ke ana ʻana i ka hana maʻi a me ka pono o ka lāʻau anti-inflammatory.

2. Ka Loiloi Pōpilikia o ka Pūnaehana Naʻau: hs-CRP
ʻO kahi holomua nui ma ke kahua, ʻo ia ka hoʻomohala ʻana o ka hoʻāʻo ʻana o ka CRP kiʻekiʻe-sensitivity (hs-CRP). Ana kēia hoʻāʻo i nā pae haʻahaʻa loa o CRP, kahi i ʻike ʻole ʻia ma mua. Ua hoʻokumu ka noiʻi ʻo ka mumū mau loa, haʻahaʻa i loko o nā paia arterial ke kumu nui o ka atherosclerosis—ka hōʻiliʻili ʻana o ka plaque hiki ke alakaʻi i nā hōʻeha puʻuwai a me nā hahau. Hana ʻo hs-CRP ma ke ʻano he biomarker ikaika no kēia mumū vascular ma lalo.
Ua ʻike ka ʻAhahui Puʻuwai ʻAmelika i ka hs-CRP ma ke ʻano he kumu pilikia kūʻokoʻa no ka maʻi cardiovascular. ʻO nā kānaka me nā pae hs-CRP ma ka pae kiʻekiʻe-maʻamau (ma luna o 3 mg/L) ua manaʻo ʻia he piʻi aʻe ka pilikia no nā hanana puʻuwai e hiki mai ana, ʻoiai inā maʻamau ko lākou pae cholesterol. No laila, hoʻohana ʻia ka hs-CRP e hoʻomaʻemaʻe i ka loiloi pilikia, ʻoi aku hoʻi no nā poʻe maʻi pilikia waena. ʻAe kēia i nā hoʻolālā pale pilikino, e like me ka hoʻomaka ʻana i ka lāʻau statin i nā kānaka i hiki ʻole ke mālama ʻia ma muli o nā kumu pilikia kuʻuna wale nō.

3. Ka Nānā ʻana i ka Pane Lapaʻau a me ka Prognosis
Ma waho aʻe o ka hōʻailona a me ka loiloi pilikia, he mea hana maikaʻi loa ʻo CRP no ka nānā ʻana i ka pane a ka mea maʻi i ka lāʻau lapaʻau. I nā maʻi lele, ʻo ka hāʻule ʻana o ka pae CRP he hōʻailona ikaika ia e kūpono ana ka lāʻau antibiotic a antimicrobial paha. Pēlā nō, i nā kūlana autoimmune, pili ka emi ʻana o CRP me ka hoʻopau pono ʻana i ka mumū e nā lāʻau immunosuppressive. ʻAe kēia ʻano ikaika i nā kauka lapaʻau e hoʻoponopono i nā hoʻolālā lapaʻau i ka manawa maoli. Eia kekahi, ʻo nā pae CRP kiʻekiʻe mau e pili pinepine ʻia me kahi prognosis ʻoi aku ka maikaʻi ʻole i nā kūlana mai ke kanesa a i ka hāʻule ʻana o ka puʻuwai, e hāʻawi ana i kahi puka makani i ke koʻikoʻi a me ke ala o ka maʻi.

Nā Palena a me ka Hopena
ʻOiai kona pono, ʻo kahi palena koʻikoʻi o CRP ʻo ia kona ʻano kikoʻī ʻole. ʻO kahi pae kiʻekiʻe e hōʻike ana i ke alo o ka mumū akā ʻaʻole ia e kuhikuhi i kona kumu. ʻO ke kaumaha, ka trauma, ka momona, a me nā maʻi maʻi hiki ke hoʻokiʻekiʻe i ka CRP. No laila, pono e wehewehe mau ʻia kona mau hopena ma ke ʻano o ka mōʻaukala lapaʻau o ka mea maʻi, ka hoʻokolokolo kino, a me nā ʻike diagnostic ʻē aʻe.

I ka hopena, he nui nā ʻano o ke koʻikoʻi o ka hoʻāʻo ʻana o CRP. Mai ka hana ʻana ma ke ʻano he hoʻāʻo mua no nā maʻi ʻoi a hiki i ka lawelawe ʻana ma ke ʻano he mea wānana akamai o ka pilikia cardiovascular lōʻihi ma o hs-CRP, he mea hana pono kēia biomarker i loko o ka arsenal o ke kauka. ʻO kona hiki ke ana a nānā pono i ka mumū ua hoʻomaikaʻi nui i ka mālama ʻana i ka mea maʻi i ka ʻike ʻana, ke alakaʻi lapaʻau, a me ka loiloi prognostic ma nā ʻano lapaʻau like ʻole.