Lub Koom Haum Nruab Nrab Ntawm Cov Kab Mob plab, Kev Laus, thiab Alzheimer's Disease Pathology

Nyob rau hauv xyoo tas los no, kev sib raug zoo ntawm plab microbiota thiab cov kab mob neurological tau dhau los ua qhov kev tshawb fawb hotspot. Ntau thiab ntau cov pov thawj qhia tau hais tias txoj hnyuv o (xws li plab hnyuv thiab dysbiosis) tuaj yeem cuam tshuam rau kev loj hlob ntawm cov kab mob neurodegenerative, tshwj xeeb tshaj yog Alzheimer's disease (AD), los ntawm "lub plab-hlwb axis". Tsab ntawv xov xwm no tshuaj xyuas seb qhov mob plab hnyuv loj npaum li cas thaum muaj hnub nyoog thiab tshawb nrhiav nws txoj kev koom tes nrog AD pathology (xws li β-amyloid deposition thiab neuroinflammation), muab cov tswv yim tshiab rau kev cuam tshuam ntxov ntawm AD.

1. Taw qhia

Alzheimer's disease (AD) yog cov kab mob neurodegenerative tshaj plaws, uas yog β-amyloid (Aβ) plaques thiab hyperphosphorylated tau protein. Txawm hais tias cov yam ntxwv ntawm caj ces (xws li, APOE4) yog qhov tseem ceeb ntawm AD kev pheej hmoo, kev cuam tshuam ib puag ncig (xws li kev noj haus, plab hnyuv) kuj tuaj yeem ua rau AD kev loj hlob los ntawm kev mob ntev. Lub plab, uas yog lub cev tiv thaiv kab mob loj tshaj plaws, tuaj yeem cuam tshuam lub hlwb kev noj qab haus huv los ntawm ntau txoj hauv kev, tshwj xeeb tshaj yog thaum laus.

2. Kev mob plab thiab kev laus

2.1 Lub hnub nyoog cuam tshuam txog kev poob qis hauv plab hnyuv ua haujlwm
Nrog lub hnub nyoog, kev ncaj ncees ntawm txoj hnyuv txo qis, ua rau "cov plab hnyuv", tso cai rau cov kab mob metabolites (xws li lipopolysaccharide, LPS) nkag mus rau hauv cov ntshav, ua rau cov kab mob qis qis. Cov kev tshawb fawb tau pom tias muaj ntau haiv neeg ntawm cov hnyuv hauv cov neeg laus txo qis, cov kab mob pro-inflammatory (xws li Proteobacteria) nce, thiab cov kab mob tiv thaiv kab mob (xws li Bifidobacterium) txo qis, ua rau cov kab mob inflammatory ntxiv.

2.2 Inflammatory yam thiab kev laus
Kev mob qis qis ("inflammatory aging", Inflamging) yog ib qho tseem ceeb ntawm kev laus. Cov kab mob plab hnyuv inflammatory (xws liIL-6, TNF-α) tuaj yeem nkag mus rau hauv lub hlwb los ntawm cov ntshav ncig, qhib microglia, txhawb kev mob ntshav qab zib, thiab ua kom cov txheej txheem pathological ntawm AD.

thiab txhawb nqa neuroinflamation, yog li ceev AD pathology.

3. Qhov Kev Sib Txuas Ntawm Cov Kab Mob plab thiab Alzheimer's Disease Pathology

3.1 Gut Dysbiosis thiab Aβ Deposition

Cov qauv tsiaj tau pom tias muaj kev cuam tshuam hauv plab hnyuv tuaj yeem ua rau Aβ deposition. Piv txwv li, cov nas tsuag tshuaj tua kab mob tau txo qis Aβ plaques, thaum Aβ qib nce hauv cov nas nrog dysbiosis. Qee cov kab mob metabolites (xws li cov saw hlau luv fatty acids, SCFAs) tuaj yeem cuam tshuam Aβ tshem tawm los ntawm kev tswj hwm microglial muaj nuj nqi.

3.2 Lub plab-Brain Axis thiab Neuroinflamation

Lub plab o tuaj yeem cuam tshuam rau lub hlwb ntawm vagal, lub cev tsis muaj zog, thiab txoj hauv kev metabolic:

• Vagal txoj hauv kev: cov kab mob plab hnyuv tau kis los ntawm cov hlab ntsha vagus mus rau CNS, cuam tshuam rau hippocampal thiab prefrontal cortex muaj nuj nqi.
• Cov kab mob o: Cov kab mob xws li LPS ua kom microglia thiab txhawb kev mob hlwb, ua rau muaj kab mob ntau ntxiv thiab kev puas tsuaj rau neuronal.
• Cov teebmeem metabolic: plab dysbiosis tuaj yeem cuam tshuam rau tryptophan metabolism, ua rau muaj qhov tsis txaus ntawm cov tshuaj neurotransmitters (xws li, 5-HT) thiab cuam tshuam rau kev paub txog kev ua haujlwm.

3.3 Cov ntaub ntawv pov thawj kho mob

• Cov neeg mob nrog AD muaj qhov sib txawv ntawm cov plab hnyuv ntau dua li cov neeg laus noj qab haus huv, piv txwv li, qhov txawv txav ntawm Thick-walled phylum / Antibacterial phylum.
• Cov ntshav ntawm LPS muaj kev cuam tshuam zoo nrog AD qhov hnyav.
• Kev cuam tshuam Probiotic (xws li Bifidobacterium bifidum) txo qis Aβ deposition thiab txhim kho kev txawj ntse hauv cov qauv tsiaj.

4. Muaj peev xwm cuam tshuam cov tswv yim

Kev hloov pauv kev noj haus: kev noj zaub mov muaj fiber ntau, Mediterranean yuav txhawb kev loj hlob ntawm cov kab mob uas muaj txiaj ntsig zoo thiab txo qhov mob.

1. Probiotics/Prebiotics: supplementation nrog cov kab mob tshwj xeeb (xws li, Lactobacillus, Bifidobacterium) tuaj yeem txhim kho lub plab ua haujlwm.
2. Cov tshuaj tiv thaiv kab mob: cov tshuaj uas tsom rau lub plab o (xws li, TLR4 inhibitors) tuaj yeem ua rau qeeb AD.
3. Kev ua neej nyob: kev tawm dag zog thiab txo kev ntxhov siab tuaj yeem ua kom lub plab muaj zog

5. Cov lus xaus thiab cov kev xav yav tom ntej

Lub plab o tuaj nrog lub hnub nyoog thiab tuaj yeem ua rau AD pathology los ntawm lub plab-hlwb axis. Cov kev tshawb fawb yav tom ntej yuav tsum tau qhia ntxiv txog kev sib raug zoo ntawm cov nroj tsuag tshwj xeeb thiab AD thiab tshawb nrhiav AD tiv thaiv thiab kho cov tswv yim raws li kev cai ntawm plab hnyuv. Kev tshawb fawb hauv cheeb tsam no tuaj yeem muab lub hom phiaj tshiab rau kev cuam tshuam ntxov hauv cov kab mob neurodegenerative.

Xiamen Baysen Kev Kho Mob Peb Baysen Kev Kho Mob yeej ib txwm tsom rau cov txheej txheem kuaj mob txhawm rau txhim kho lub neej zoo. Peb tau tsim 5 thev naus laus zis platforms- Latex, colloidal kub, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Peb tsom mus rau lub plab noj qab haus huv, thiab pebCAL xeem yog siv los txheeb xyuas qhov mob hauv plab.

Cov ntaub ntawv:

1. Vogt, NM, et al. (2017). "Kev hloov pauv hauv plab microbiome hauv Alzheimer's tus kab mob."Kev Tshaj Tawm Txog Kev Tshawb Fawb.
2. Dodiya, HB, et al. (2020). "Cov kab mob hauv lub plab ntev exacerbates tau pathology hauv tus qauv nas ntawm Alzheimer's disease."Nature Neuroscience.
3. Franceschi, C., et al. (2018). "Inflamging: ib qho kev tiv thaiv kab mob-metabolic tshiab rau cov kab mob uas muaj hnub nyoog."Nature Reviews Endocrinology.