Kev sib raug zoo ntawm Fatty Liver thiab Insulin

Kev sib raug zoo ntawm Fatty Liver thiab Glycated Insulin yog ib qho kev sib raug zoo ntawm lub siab rog (tshwj xeeb tshaj yog cov kab mob tsis muaj dej cawv fatty siab, NAFLD) thiabinsulin(los yoginsulintsis kam, hyperinsulinemia), uas yog kho feem ntau los ntawm cov kab mob metabolic (xws li rog rog, hom 2.ntshav qab zib,lwm yam). Cov hauv qab no yog cov ncauj lus kom ntxaws txog cov ntsiab lus tseem ceeb:

1. InsulinTsis kam raws li Core Mechanism

• InsulinResistance (IR) yog ib hom kab mob pathological rau lub siab rog thiab cov piam thaj metabolism tsis zoo. Thaum lub cev rhiab heev rau insulin txo qis, pancreas compensatorily secretes ntau duainsulinhyperinsulinemia (hyperinsulinemia), uas ua rau cov ntshav insulin nce siab.
• Cov txiaj ntsig ntawm daim siab rog: mob siabinsulininhibits fatty acid oxidation, txhawb cov rog synthesis (lipid deposition), thiab exacerbates cov rog nyob rau hauv hepatocytes (steatosis).
• Koom nrogHbA1c: Txawm hais tias glycated insulin tsis yog ib qho kev siv tshuaj kho mob, qhov ntev hyperglycemia (txuas mus rau IR) nce glycated hemoglobin.(HbA1c), qhia txog kev tswj ntshav qab zib tsis zoo, uas cuam tshuam nrog kev loj hlob ntawm lub siab rog mus rau cov tsis muaj cawv steatohepatitis (NASH).

2. Hyperinsulinemia txhawb kev rog rog

• Kev txiav txim ncaj qha: Hyperinsulinemia txhawb lub siab lipogenesis (↑ lipid synthesis) los ntawm kev ua kom muaj kev hloov pauv (xws li SREBP-1c) thaum inhibiting fatty acid β-oxidation.
• Indirect Effect:Insulintsis kam ua rau cov ntaub so ntswg adipose tso tawm ntau cov roj fatty acids (FFAs), uas nkag mus rau hauv daim siab thiab hloov mus rau hauv triglycerides, ua rau lub siab rog ntxiv.

3. Fatty Liver Exacerbates abnormality glucose metabolism

• Mob siabInsulinKuj: Lub siab rog tso tawm cov cytokines inflammatory (piv txwv li, TNF-α,IL-6) thiab adipokines (piv txwv li, leptin tsis kam, txo adiponectin), ua rau lub cev tsis zoo ntawm cov tshuaj insulin.
• Ua kom cov ntshav qabzib ntau ntxiv:insulinKev tsis kam ua rau lub siab tsis muaj peev xwm ua kom tsis zoo ntawm gluconeogenesis, thiab nce ntshav qabzib nrawm ntxiv ua rau cov piam thaj metabolism tsis zoo (muaj peev xwm ua rau mob ntshav qab zib hom 2).

4. Cov ntaub ntawv pov thawj kho mob:Glycosylated hemoglobin (HbA1c)thiab Fatty Liver

• Kev nce qib HbA1c kwv yees kev pheej hmoo rog rog: ntau qhov kev tshawb fawb tau pom tiasHbA1cCov qib muaj txiaj ntsig zoo nrog rau lub siab mob hnyav, txawm tias cov txheej txheem kuaj ntshav qab zib tsis tau ua tiav (kev pheej hmoo yog nce ntxiv nrog HbA1c ≥ 5.7%).
• Glycemic Control hauv Fatty Liver Patients: Cov neeg mob ntshav qab zib uas muaj lub siab rog tuaj yeem xav tau kev tswj hwm ntshav qab zib kom nruj (qis HbA1c lub hom phiaj) kom qeeb kab mob siab.

5. Cov tswv yim cuam tshuam: Txhim khoInsulinrhiab heev

• Kev hloov pauv hauv kev ua neej: poob phaus (5-10% poob phaus ua kom lub siab rog), tsis muaj carbohydrate / rog tsawg, kev tawm dag zog aerobic.
• Cov tshuaj:
  • Insulinsensitizers (piv txwv li, metformin, pioglitazone) tuaj yeem txhim kho lub siab rog thiab qabzib metabolism.
  • GLP-1 receptor agonists (piv txwv li, liraglutide, semaglutide) pab txo qhov hnyav, tswj glycemic, thiab txo cov rog rog.
• Saib xyuas: yoo movinsulin, HOMA-IR (insulin resistance index), HbA1c thiab daim siab imaging / elastography tau raug kuaj tsis tu ncua.

Xaus

Lub cev rog thiab insulin (los yog hyperinsulinemia) tsim ib lub voj voog vicious los ntawm insulin tsis kam. Kev cuam tshuam thaum ntxov ntawminsulinkev tiv thaiv txhim kho ob lub siab rog thiab qabzib metabolism thiab txo qhov kev pheej hmoo ntawm ntshav qab zib thiab daim siab fibrosis. Metabolic markers yuav tsum tau soj ntsuam ua ke nyob rau hauv lub tsev kho mob es tsis yog tsom rau ib tug qhia ib leeg.

Peb Baysen Medical yeej ib txwm tsom rau cov txheej txheem kuaj mob txhawm rau txhim kho lub neej zoo. Peb tau tsim 5 thev naus laus zis platforms- Latex, colloidal kub, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, PebKev kuaj HbA1c,Kev kuaj tshuaj insulinthiabKev kuaj C-peptide Kev ua haujlwm yooj yim thiab tuaj yeem tau txais txiaj ntsig hauv 15 mins