Kev Sib Raug Zoo Ntawm Cov Neeg Mob Siab Rog Thiab Insulin

Kev Sib Raug Zoo Ntawm Cov Neeg Mob Siab Rog Thiab Glycated Insulin yog kev sib raug zoo ntawm cov neeg mob siab rog (tshwj xeeb tshaj yog cov neeg mob siab rog uas tsis yog cawv, NAFLD) thiabinsulin(los yoginsulinkev tsis kam, hyperinsulinemia), uas yog mediated feem ntau los ntawm metabolic teeb meem (piv txwv li, rog dhau, hom 2mob ntshav qab zib,thiab lwm yam). Cov hauv qab no yog kev tshuaj xyuas ntxaws ntxaws ntawm cov ntsiab lus tseem ceeb:

1. InsulinKev Tiv Thaiv Ua Lub Hauv Paus Tseem Ceeb

• Insulinkev tiv thaiv (IR) yog ib qho mob uas tshwm sim ntau rau daim siab rog thiab kev ua haujlwm tsis zoo ntawm cov piam thaj. Thaum lub cev tsis kam rau insulin txo qis, lub txiav ua rau lub cev tso tawm ntau dua.insulin(hyperinsulinemia), ua rau cov insulin hauv cov ntshav nce siab.
• Cov txiaj ntsig ntawm daim siab rog: hepaticinsulinkev tiv thaiv inhibits fatty acid oxidation, txhawb nqa cov rog synthesis (lipid deposition), thiab ua rau cov rog sib sau ua ke hauv hepatocytes (steatosis).
• Kev koom tes nrogHbA1cTxawm hais tias glycated insulin tsis yog ib qho cim qhia kev kho mob uas siv ntau, hyperglycemia ntev (txuas nrog IR) ua rau glycated hemoglobin nce ntxiv.(HbA1c), qhia txog kev tswj cov ntshav qab zib tsis zoo, uas cuam tshuam nrog kev nce qib ntawm daim siab rog mus rau qhov mob steatohepatitis uas tsis yog cawv (NASH).

2. Hyperinsulinemia Ua rau muaj kab mob rog ntau dhau

• Kev Ua Haujlwm Ncaj Qha: Hyperinsulinemia txhawb nqa hepatic lipogenesis (↑ lipid synthesis) los ntawm kev ua kom cov transcription factors (piv txwv li SREBP-1c) ua haujlwm thaum tiv thaiv fatty acid β-oxidation.
• Cov Nyhuv Tsis Ncaj Qha:Insulinkev tsis kam ua rau cov ntaub so ntswg adipose tso tawm ntau cov roj fatty acids (FFAs), uas nkag mus rau hauv daim siab thiab hloov mus ua triglycerides, ua rau daim siab rog zuj zus.

3. Mob siab rog ua rau cov metabolism glucose tsis zoo dua qub

• Ua rau mob siabInsulinKev Tiv Thaiv: Cov rog hauv siab tso tawm cov cytokines inflammatory (piv txwv li, TNF-α,IL-6) thiab adipokines (piv txwv li, kev tiv thaiv leptin, txo qis adiponectin), ua rau kev tiv thaiv insulin hauv lub cev zuj zus tuaj.
• Kev tso zis qabzib ntau ntxiv hauv lub siab:insulinqhov kev tiv thaiv ua rau lub siab tsis muaj peev xwm tiv thaiv gluconeogenesis kom zoo, thiab cov ntshav qab zib thaum noj ntau dhau ua rau cov metabolism glucose phem dua (tej zaum yuav mus rau ntshav qab zib hom 2).

4. Cov Pov Thawj Kho Mob:Glycosylated Hemoglobin (HbA1c)thiab Rog Siab

• Kev nce HbA1c kwv yees qhov kev pheej hmoo ntawm daim siab rog: ntau txoj kev tshawb fawb tau qhia tiasHbA1ccov qib no muaj feem cuam tshuam zoo nrog qhov hnyav ntawm daim siab rog, txawm tias thaum cov qauv kuaj mob ntshav qab zib tsis tau ua tiav (kev pheej hmoo nce ntxiv nrog HbA1c ≥ 5.7%).
• Kev Tswj Glycemic rau Cov Neeg Mob Siab Rog: Cov neeg mob ntshav qab zib uas muaj siab rog yuav xav tau kev tswj ntshav qab zib kom nruj dua (cov hom phiaj HbA1c qis dua) kom qeeb qeeb kev loj hlob ntawm tus kab mob siab.

5. Cov Tswv Yim Pab Cuam: Kev Txhim KhoInsulinKev rhiab heev

• Kev hloov pauv txoj kev ua neej: kev poob phaus (kev poob phaus 5-10% ua rau lub siab rog zoo dua), kev noj zaub mov uas muaj carbohydrate tsawg/rog tsawg, kev tawm dag zog aerobic.
• Cov Tshuaj:
  • Insulinscov tshuaj ua rau lub siab ua haujlwm (piv txwv li, metformin, pioglitazone) tuaj yeem txhim kho cov rog hauv daim siab thiab cov metabolism glucose.
  • Cov tshuaj GLP-1 receptor agonists (piv txwv li, liraglutide, semaglutide) pab txo qhov hnyav, tswj glycemic, thiab txo cov rog hauv siab.
• Kev Soj Ntsuam: Kev Yoo Movinsulin, HOMA-IR (insulin resistance index), HbA1c thiab daim siab imaging/elastography raug kuaj tsis tu ncua.

Xaus lus

Mob siab rog thiab insulin (lossis hyperinsulinemia) tsim ib lub voj voog phem los ntawm kev tsis kam insulin. Kev cuam tshuam thaum ntxov ntawminsulinkev tiv thaiv ua rau ob qho tib si rog thiab glucose metabolism thiab txo qhov kev pheej hmoo ntawm ntshav qab zib thiab daim siab fibrosis. Cov cim qhia metabolic yuav tsum tau soj ntsuam ua ke hauv tsev kho mob es tsis txhob tsom mus rau ib qho cim xwb.

Peb Baysen Medical yeej ib txwm tsom mus rau kev kuaj mob kom zoo dua qub. Peb tau tsim 5 lub platform thev naus laus zis - Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, PebKev kuaj HbA1c,Kev kuaj insulinthiabKev kuaj C-peptide yooj yim ua haujlwm thiab tuaj yeem tau txais cov txiaj ntsig sim hauv 15 feeb