Ferritin: Tus Biomarker nrawm thiab raug rau kev kuaj xyuas cov hlau tsis txaus thiab ntshav ntshav

Taw qhia

Iron deficiency thiab anemia yog cov teeb meem kev noj qab haus huv thoob ntiaj teb, tshwj xeeb tshaj yog nyob rau hauv cov teb chaws tsim, cov poj niam cev xeeb tub, menyuam yaus thiab cov poj niam uas muaj hnub nyoog me nyuam. Hlau deficiency anemia (IDA) tsis tsuas yog cuam tshuam rau lub cev thiab kev paub txog kev ua haujlwm ntawm tib neeg, tab sis kuj tseem tuaj yeem ua rau muaj kev pheej hmoo ntawm cev xeeb tub thiab kev loj hlob qeeb hauv cov menyuam yaus. Yog li ntawd, kev tshuaj xyuas ntxov thiab kev cuam tshuam yog qhov tseem ceeb. Ntawm ntau qhov ntsuas ntsuas, ferritin tau dhau los ua cov cuab yeej tseem ceeb rau kev tshuaj xyuas cov hlau tsis txaus thiab ntshav ntshav vim nws qhov siab thiab qhov tshwj xeeb. Kab lus no yuav tham txog cov yam ntxwv lom neeg ntawm ferritin, nws qhov zoo hauv kev kuaj mob ntawm cov hlau tsis muaj peev xwm thiab ntshav ntshav, thiab nws cov nqi kho mob.

Biological yam ntxwv ntawmFerritin

Ferritinyog ib qho hlau cia protein ntau nyob rau hauv tib neeg cov ntaub so ntswg. Nws yog tsim los ntawm lub siab, spleen thiab pob txha pob txha. Nws lub luag haujlwm tseem ceeb yog khaws cov hlau thiab tswj qhov sib npaug ntawm cov hlau metabolism. Hauv cov ntshav, qhov concentration ntawmtshuaj ferritinyog zoo correlated nrog lub cev cov hlau reserves. Yog li ntawd, serumtshuaj ferritinqib yog ib qho ntawm cov cim qhia tau zoo tshaj plaws ntawm lub cev cov hlau cia. Hauv cov xwm txheej ib txwm muaj, qib ferritin hauv cov txiv neej laus yog kwv yees li 30-400 ng / mL, thiab hauv cov poj niam nws yog 15-150 ng / mL, tab sis nyob rau hauv cov ntaub ntawv ntawm cov hlau tsis txaus, tus nqi no yuav txo qis.

Qhov zoo ntawmFerritinnyob rau hauv Iron Deficiency Screening

1. Siab rhiab heev, kev tshawb pom ntxov ntawm cov hlau tsis txaus

Txoj kev loj hlob ntawm cov hlau tsis txaus yog muab faib ua peb theem:

• Hlau deficiency theem: cia hlau(ferritin) txo qis, tab sis hemoglobin yog qhov qub;
• Iron deficiency erythropoiesis theem:tshuaj ferritinntxiv txo, transferrin saturation txo;
• Iron deficiency anemia theem: hemoglobin txo qis, thiab cov tsos mob tshwm sim tshwm sim.

Cov kev tshuaj ntsuam niaj hnub (xws li kev kuaj hemoglobin) tsuas yog kuaj pom muaj teeb meem hauv theem ntshav ntshav, thaumtshuaj ferritinkev ntsuam xyuas tuaj yeem kuaj pom qhov txawv txav nyob rau theem pib ntawm cov hlau tsis txaus, yog li muab lub sijhawm rau kev cuam tshuam ntxov.

2. High Specificity, txo qhov tsis zoo

Ntau yam kab mob (xws li mob ntev thiab kab mob) tuaj yeem ua rau mob ntshav qab zib, tab sis lawv tsis yog tshwm sim los ntawm kev tsis muaj hlau. Hauv qhov no, tsuas yog tso siab rau hemoglobin lossis txhais tau tias lub cev ntim (MCV) tuaj yeem txiav txim siab qhov ua rau.FerritinKev ntsuam xyuas tuaj yeem paub qhov txawv ntawm cov hlau tsis muaj peev xwm anemia los ntawm lwm hom kab mob ntshav qab zib (xws li ntshav qab zib ntawm cov kab mob ntev), txhim kho kev kuaj mob kom raug.

3. Ceev thiab yooj yim, haum rau kev ntsuam xyuas loj

Kev sim tshuaj biochemical niaj hnub ua rau kev txiav txim siab ferritin sai dua thiab siv nyiaj ntau dua, thiab tsim nyog rau cov haujlwm kev noj qab haus huv rau pej xeem xws li kev tshuaj xyuas hauv zej zog, kev saib xyuas kev noj qab haus huv niam thiab menyuam mos, thiab kev saib xyuas kev noj qab haus huv rau menyuam yaus. Piv nrog rau kev kuaj mob xws li pob txha pob txha hlau staining (tus qauv kub), kev kuaj ntshav ferritin yog yooj yim los txhawb.

Kev siv tshuaj kho mob ntawm Ferritin hauv kev tswj ntshav qab zib

1. Kev cob qhia kev kho hlau ntxiv

Ferritinqib tuaj yeem pab cov kws kho mob txiav txim siab seb cov neeg mob puas xav tau cov hlau ntxiv thiab saib xyuas cov txiaj ntsig ntawm kev kho mob. Piv txwv li:

• Ferritin<30 ng / mL: qhia tias cov hlau reserves yog depleted thiab ntxiv hlau yuav tsum tau;
• Ferritin<15 ng/mL: qhia tau hais tias tsis muaj hlau tsis txaus anemia;
• Thaum kho tau zoo, tshuaj ferritin cov qib yuav maj mam nce thiab tuaj yeem siv los ntsuas qhov ua tau zoo

1. Kev cob qhia hlau ntxiv

Ferritinqib pab cov kws kho mob txiav txim siab qhov xav tau kev kho hlau thiab saib xyuas kev kho mob. Piv txwv li:

• Ferritin<30 ng/mL: Qhia cov khw muag khoom hlau uas tsis muaj zog, xav tau kev pab ntxiv.
• Ferritin<15 ng/mL: Qhia tau tias muaj hlau deficiency anemia.
• Thaum kho, ncetshuaj ferritintheem paub meej tias kho tau zoo.

2. Kev tshuaj xyuas cov neeg tshwj xeeb

• Cov poj niam cev xeeb tub: xav tau hlau ntxiv thaum cev xeeb tub, thiabtshuaj ferritinkev ntsuam xyuas tuaj yeem tiv thaiv cov teeb meem ntawm niam thiab menyuam mos.
• Cov menyuam yaus: tsis muaj hlau tsis muaj peev xwm cuam tshuam rau kev paub txog kev loj hlob, thiab kev tshuaj xyuas ntxov tuaj yeem txhim kho kev mob tshwm sim.
• Cov neeg mob uas muaj kab mob ntev: xws li cov neeg mob raum thiab mob plab hnyuv,tshuaj ferritin ua ke nrog transferrin saturation tuaj yeem txheeb xyuas hom ntshav qab zib.

Kev txwv ntawmFerritinKev sim thiab kev daws teeb meem

Txawm hais tias ferritin yog qhov zoo tshaj plaws rau kev kuaj xyuas cov hlau tsis txaus, nws yuav tsum tau txhais nrog ceev faj hauv qee qhov xwm txheej:

• Inflammation los yog kab mob:Ferritin, raws li ib tug mob theem reactant protein, tej zaum yuav dag elevated nyob rau hauv tus kab mob, qog los yog mob o. Hauv qhov no, nws tuaj yeem ua ke nrogC-reactive protein (CRP) orkev hloov pauvsaturation rau kev txiav txim siab.
• Kab mob siab:Ferritinnyob rau hauv cov neeg mob uas muaj cirrhosis yuav nce vim lub siab cell puas thiab yuav tsum tau soj ntsuam nyob rau hauv ua ke nrog nrog rau lwm cov hlau metabolism hauv.

Xaus

Ferritinkev kuaj tau dhau los ua ib qho tseem ceeb rau kev tshuaj xyuas cov hlau tsis txaus thiab ntshav ntshav vim nws qhov siab, qhov tshwj xeeb thiab yooj yim. Nws tuaj yeem tsis tsuas yog kuaj pom qhov tsis txaus ntawm cov hlau thaum ntxov thiab zam kev mob ntshav qab zib, tab sis kuj qhia kev kho kom raug thiab txhim kho tus neeg mob cov tsos mob. Hauv kev noj qab haus huv pej xeem thiab kev kho mob, kev txhawb nqa ntawmtshuaj ferritin Kev kuaj mob tuaj yeem pab txo qis tus kab mob ntawm cov kab mob tsis muaj hlau tsis txaus, tshwj xeeb tshaj yog rau cov neeg muaj kev pheej hmoo siab (xws li cov poj niam cev xeeb tub, menyuam yaus thiab cov neeg mob uas muaj kab mob ntev). Nyob rau hauv lub neej yav tom ntej, nrog rau kev nce qib ntawm kev tshawb nrhiav technology,tshuaj ferritin tuaj yeem ua lub luag haujlwm ntau dua hauv kev tiv thaiv thiab tswj ntshav qab zib hauv ntiaj teb.

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