Òtù Na-ahụ Maka Ọrịa Gut, Ịka nká, na Ọrịa Ọrịa Alzheimer

N'afọ ndị na-adịbeghị anya, mmekọrịta dị n'etiti microbiota gut na ọrịa akwara aghọọla ebe nyocha. Ihe akaebe na-aga n'ihu na-egosi na mbufụt nke eriri afọ (dị ka eriri afọ na dysbiosis) nwere ike imetụta ọganihu nke ọrịa neurodegenerative, karịsịa ọrịa Alzheimer (AD), site na "gut-brain axis". Edemede a na-enyocha ka mbufụt nke eriri afọ na-abawanye na afọ ma na-enyocha njikọ ya na pathology AD (dị ka β-amyloid deposition na neuroinflammation), na-enye echiche ọhụrụ maka itinye aka n'oge AD.

1. Okwu mmalite

Ọrịa Alzheimer (AD) bụ ọrịa neurodegenerative na-ahụkarị, nke e ji β-amyloid (Aβ) plaques na protein hyperphosphorylated tau mara. Ọ bụ ezie na mkpụrụ ndụ ihe nketa (dịka, APOE4) bụ isi ihe ize ndụ AD, mmetụta gburugburu ebe obibi (dịka, nri, ahụike eriri afọ) nwekwara ike inye aka na ọganihu AD site na mbufụt na-adịghị ala ala. Ọkpụkpụ, dị ka akụkụ ahụ kachasị na-alụso ọrịa ọgụ, nwere ike imetụta ahụike ụbụrụ site n'ọtụtụ ụzọ, ọkachasị n'oge ịka nká.

2. Gut Inflammation and Aging

2.1 Mbelata afọ metụtara ọrụ mgbochi eriri afọ
Ka ọ na-erule afọ, iguzosi ike n'ezi ihe nke mgbochi eriri afọ na-ebelata, na-eduga na "gut leaky", na-ekwe ka metabolites nke nje bacteria (dị ka lipopolysaccharide, LPS) banye n'ọbara ọbara, na-ebute mbufụt nke obere ọkwa. Nnyocha e mere egosiwo na ụdị dị iche iche nke intestinal flora na ndị agadi na-ebelata, nje bacteria pro-inflammatory (dị ka Proteobacteria) na-abawanye, na nje bacteria na-egbochi ọrịa (dị ka Bifidobacterium) na-ebelata, na-eme ka mmeghachi omume na-egbuke egbuke dịkwuo njọ.

2.2 Ihe na-egbu egbu na ịka nká
Ọrịa na-adịghị ala ala na-adịghị ala ala ("ịka nká na-egbu egbu", Mgbu) bụ akụkụ dị mkpa nke ịka nká. Ihe na-akpata mkpali eriri afọ (dịkaIL-6, TNF-α) nwere ike ịbanye n'ụbụrụ site na mgbasa ọbara, mee ka microglia rụọ ọrụ, kwalite neuroinflammation, ma mee ka usoro pathological nke AD dịkwuo elu.

ma na-akwalite neuroinflammation, si otú a na-eme ngwa ngwa AD pathology.

3. Njikọ n'etiti Gut Inflammation na Alzheimer's Disease Pathology

3.1 Dysbiosis gut na ntinye Aβ

Ụdị anụmanụ egosila na mgbakasị osisi nke eriri afọ nwere ike ịbawanye ntinye Aβ. Dịka ọmụmaatụ, ụmụ oke ejiri ọgwụ nje belatara plaques Aβ, ebe ọkwa Aβ na-abawanye na ụmụ oke nwere dysbiosis. Ụfọdụ metabolites nke nje bacteria (dị ka acid fatty nke dị mkpụmkpụ, SCFAs) nwere ike imetụta mkpochapụ Aβ site na ịhazi ọrụ microglial.

3.2 The Gut-Brain Axis na Neuroinflammation

Ọrịa gut nwere ike imetụta ụbụrụ site na vagal, sistemu ahụ ji alụso ọrịa ọgụ, na ụzọ metabolic:

• Ụzọ Vagal: A na-ebunye mgbaàmà mkpali nke eriri afọ site na akwara vagus na CNS, na-emetụta ọrụ hippocampal na prefrontal cortex.
• Ọrịa sistemu: akụrụngwa nje dị ka LPS na-arụ ọrụ microglia ma na-akwalite neuroinflammation, na-akawanye njọ tau pathology na mmebi neuronal.
• Mmetụta metabolic: dysbiosis gut nwere ike imetụta metabolism tryptophan, na-eduga na adịghị mma na neurotransmitters (dịka, 5-HT) ma na-emetụta ọrụ ọgụgụ isi.

3.3 Ihe akaebe gbasara ahụike

• Ndị ọrịa nwere AD nwere nnukwu ihe mejupụtara ahịhịa gut karịa ndị okenye nwere ahụike, dịka ọmụmaatụ, oke dị njọ nke phylum gbara ọkpụrụkpụ/Antibacterial phylum.
• Ọkwa ọbara nke LPS na-ejikọta nke ọma na ịdị njọ AD.
• Ihe omume probiotic (dịka Bifidobacterium bifidum) na-ebelata ntinye Aβ ma melite ọrụ ọgụgụ isi na ụdị anụmanụ.

4. Usoro ntinye aka nwere ike ime

Mgbanwe nri nri: nri nwere eriri dị elu, nri Mediterranean nwere ike ịkwalite uto nke nje bacteria bara uru ma belata mbufụt.

1. Probiotics/Prebiotics: mgbakwunye na ụdị nje bacteria dị iche iche (dịka, Lactobacillus, Bifidobacterium) nwere ike melite ọrụ mgbochi afọ.
2. Ọgwụ mgbochi mkpali: ọgwụ ndị na-elekwasị anya mbufụt nke eriri afọ (dịka ọmụmaatụ, TLR4 inhibitors) nwere ike belata ọganihu AD.
3. Ntinye aka n'ụdị ndụ: mmega ahụ na mbelata nchekasị nwere ike idowe nguzozi nke osisi gut

5. Mmechi na Echiche Ọdịnihu

Mfụfụ nke eriri afọ na-abawanye na afọ ma nwee ike itinye aka na pathology AD site na axis-ụbụrụ. Ọmụmụ ihe ga-eme n'ọdịnihu kwesịrị dokwuo anya mmekọrịta kpatara dị n'etiti ahịhịa ahịhịa na AD wee nyochaa mgbochi AD na usoro ọgwụgwọ dabere na ụkpụrụ gut flora. Nnyocha dị na mpaghara a nwere ike ịnye ebumnuche ọhụrụ maka itinye aka n'oge na ọrịa neurodegenerative.

Xiamen Baysen Medical Anyị Baysen Medical na-elekwasị anya mgbe niile na usoro nyocha iji melite ogo ndụ. Anyị emepụtala nyiwe teknụzụ 5- Latex, ọla edo colloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Anyị na-elekwasị anya na ahụike eriri afọ, na nke anyịNnwale CAL a na-eji achọpụta mbufụt na eriri afọ.

Ntụaka:

1. Vogt, NM, et al. (2017). "Mgbanwe microbiome gut na ọrịa Alzheimer."Akụkọ Sayensị.
2. Dodiya, HB, et al. (2020). "Mfụfụ nke eriri afọ na-adịghị ala ala na-eme ka ọrịa tau ka njọ n'ụdị òké nke ọrịa Alzheimer."Nature Neuroscience.
3. Franceschi, C., et al. (2018). "Mgba ọkụ: echiche ọhụrụ na-alụso ọrịa ọgụ-metabolic maka ọrịa ndị metụtara afọ."Nleba anya nke okike endocrinology.