Mmekọrịta dị n'etiti imeju abụba na Insulin

Mmekọrịta dị n'etiti imeju abụba na insulin Glyced bụ njikọ chiri anya n'etiti imeju abụba (karịsịa ọrịa imeju abụba na-abụghị mmanya, NAFLD) nainsulin(maọbụinsuliniguzogide, hyperinsulinemia), nke a na-akpatakarị site na nsogbu metabolic (dịka ọmụmaatụ, oke ibu, ụdị nke abụọ)ọrịa shuga,wdg.). Ihe ndị a bụ nyocha zuru ezu nke isi ihe ndị a:

1. InsulinNguzogide Dị Ka Isi Usoro

• Insuliniguzogide ọrịa (IR) bụ ihe ndabere maka imeju abụba na metabolism glucose na-adịghị mma. Mgbe mmetụta ahụ na insulin na-ebelata, pancreas na-ewepụta ihe karịrị nke ahụ.insulinhyperinsulinemia (mmụba insulin n'ọbara), nke na-eduga n'ịba ụba n'ọbara.
• Nsonaazụ nke imeju abụba: imejuinsulinNguzogide na-egbochi oxidation nke abụba abụba, na-akwalite mmepụta abụba (ntinye lipid), ma na-eme ka mkpokọta abụba dị na hepatocytes (steatosis) ka njọ.
• Njikọ naHbA1cỌ bụ ezie na insulin glycated abụghị ihe a na-ejikarị eme ihe n'ụlọ ọgwụ, hyperglycemia ogologo oge (nke jikọtara ya na IR) na-eme ka hemoglobin glycated dịkwuo elu(HbA1c), na-egosipụta enweghị njikwa shuga dị n'ọbara, nke jikọtara ya na mmụba nke imeju abụba na steatohepatitis na-abụghị mmanya (NASH).

2. Hyperinsulinemia Na-akwalite Ọrịa Imeju Abụba

• Ihe a na-eme ozugbo: Hyperinsulinemia na-akwalite lipogenesis imeju (↑ njikọta lipid) site na ịgbalite ihe ndị na-emepụta ihe (dịka ọmụmaatụ SREBP-1c) ebe ọ na-egbochi β-oxidation nke abụba acid.
• Mmetụta Na-apụtaghị ìhè:Insuliniguzogide ọrịa na-eme ka anụ ahụ abụba na-ewepụta ọtụtụ abụba efu (FFAs), nke na-abanye n'ime imeju ma ghọọ triglycerides, na-eme ka imeju abụba ka njọ.

3. Imeju Abụba Na-eme ka metabolism glucose na-adịghị mma ka njọ

• Mmebi imejuInsulinNguzogide: Imeju abụba na-ewepụta cytokines na-akpata mbufụt (dịka ọmụmaatụ, TNF-α,IL-6) na adipokines (dịka ọmụmaatụ, iguzogide leptin, mbelata adiponectin), na-eme ka iguzogide insulin sistemụ ka njọ.
• Mmụba nke glucose imeju:insuliniguzogide ọrịa na-eme ka imeju ghara inwe ike igbochi gluconeogenesis nke ọma, mmụba nke glucose ọbara na-ebu ọnụ na-emekwa ka metabolism glucose ka njọ (ọ ga-ekwe omume ịmalite ịrịa ọrịa shuga nke ụdị nke abụọ).

4. Ihe Akaebe nke Ọgwụ:Hemoglobin Glycosylated (HbA1c)na imeju abụba

• Mmụba HbA1c na-ebu amụma ihe egwu dị na imeju abụba: ọtụtụ ọmụmụ egosila naHbA1cỌkwa dị n'ọbara na-enwe njikọ dị mma na oke imeju abụba, ọbụlagodi mgbe emezughị ihe achọrọ maka nchọpụta ọrịa shuga (ihe egwu na-abawanye nke ukwuu ma ọ bụrụ na HbA1c ≥ 5.7%).
• Njikwa Glycemic n'ime Ndị Ọrịa Imeju Na-akpata Abụba: Ndị ọrịa nwere ọrịa shuga nwere imeju abụba nwere ike ịchọ nlekọta siri ike n'ọbara shuga (ebe HbA1c dị ala) iji belata ọganihu ọrịa imeju.

5. Atụmatụ Ntinye Aka: ImeziwanyeInsulinMmetụta uche

• Mgbanwe ndụ: mbelata ibu (5-10% mbelata ibu na-eme ka imeju abụba dịkwuo mma nke ukwuu), nri nwere obere carbohydrate/ obere abụba, mmega ahụ aerobic.
• Ọgwụ:
  • InsulinsEnsitizers (dịka ọmụmaatụ, metformin, pioglitazone) nwere ike ime ka imeju abụba na glucose metabolism dịkwuo mma.
  • Ndị na-anabata GLP-1 (dịka ọmụmaatụ, liraglutide, semaglutide) na-enyere aka na mbelata ibu, njikwa glycemic, na mbelata imeju abụba.
• Nlekota: Ibu ỌnụinsulinA na-anwale HOMA-IR (insulin resistance index), HbA1c na onyonyo imeju/elastography mgbe niile.

Mmechi

Oke imeju na insulin (ma ọ bụ hyperinsulinemia) na-etolite usoro ọjọọ site na iguzogide insulin.insuliniguzogide ọrịa imeju na-eme ka metabolism abụba na glucose dịkwuo mma ma na-ebelata ohere nke ọrịa shuga na fibrosis imeju. A ga-enyocha ihe nrịbama metabolic ọnụ n'ụlọ ọgwụ kama ilekwasị anya naanị n'otu ihe ngosi.

Anyị Baysen Medical na-elekwasị anya mgbe niile n'usoro nchọpụta iji melite ụdị ndụ. Anyị emepụtala ikpo okwu teknụzụ ise - Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, AnyịNnwale HbA1c,Nnwale insulinnaNnwale C-peptide ọrụ dị mfe ma nwee ike nweta nsonaazụ ule n'ime nkeji iri na ise