KUGWIRITSA NTCHITO KOFUNIKA

Chida Chodziwira Matenda chaulere Prostate Specific Antigen (fluorescence immunochromatographic assay) ndi njira yoyesera ya fluorescence immunochromatographic yowunikira kuchuluka kwa Prostate Specific Antigen (fPSA) yaulere mu seramu yamagazi ya anthu kapena plasma. Chiŵerengero cha fPSA/tPSA chingagwiritsidwe ntchito pozindikira khansa ya prostate ndi hyperplasia ya benign prostatic. Zitsanzo zonse zabwino ziyenera kutsimikiziridwa ndi njira zina. Mayesowa ndi a akatswiri azaumoyo okha.

CHIDULE

Antigen yaulere ya prostate-specific (fPSA) ndi antigen yeniyeni ya prostate yomwe imatulutsidwa m'magazi mu mawonekedwe aulere ndipo imatulutsidwa ndi maselo a epithelial a prostate. PSA (Prostate Specific Antigen) imapangidwa ndikutulutsidwa ndi maselo a epithelial a prostate kupita ku umuna ndipo ndi imodzi mwa zigawo zazikulu za plasma ya seminal. Ili ndi ma amino acid residues 237 ndipo kulemera kwake kwa molekyulu ndi pafupifupi 34kD. Ili ndi serine protease activity ya single chain glycoprotein, yomwe imagwira ntchito mu ndondomeko ya liquefaction ya umuna. PSA m'magazi ndi kuchuluka kwa PSA yaulere ndi PSA yophatikizidwa. Mu plasma yamagazi, mu 4 ng/mL yamtengo wapatali, PSA mu khansa ya prostate Ⅰ ~ Ⅳ nthawi ya kukhudzidwa kwa 63%, 71%, 81% ndi 88% motsatana.