Interleukin-6 ndi polypeptide yomwe imakhala ndi maunyolo awiri a glycoprotein, omwe ali ndi kulemera kwa 130kd. Monga membala wofunikira wa netiweki ya cytokine, interleukin-6 (IL-6) imathandizira kwambiri pakutupa kwambiri, ndipo imatha kuyimira gawo lowopsa la chiwindi, ndikulimbikitsa kupanga mapuloteni a C-reactive (CRP) ndi fibrinogen. Matenda ambiri opatsirana angayambitse kukwera kwa seramu IL-6, ndipo mlingo wa IL-6 umagwirizana kwambiri ndi zotsatira za odwala. Monga pleiotropic cytokine yokhala ndi ntchito zambiri, IL-6 imatulutsidwa ndi T cell, B cell, mononuclear phagocyte, ndi endothelial cell, ndipo ndi gawo lofunikira la network yotupa mkhalapakati. Zikachitika zotupa, IL-6's idapangidwa koyamba, yomwe imapangitsa kuti CRP ndi procalcitonin (PCT) ipangidwe. Adzapangidwa mwachangu ngati atadwala, kuvulala kwamkati ndi kunja, opaleshoni, kupsinjika maganizo, kufa kwaubongo, tumorigenesis, ndi njira yotupa yotupa ya zochitika zina. IL-6 imakhudzidwa ndi zochitika ndi chitukuko cha matenda ambiri, mlingo wake wa magazi umagwirizana kwambiri ndi kutupa, kachilombo ka HIV ndi matenda a autoimmune, ndipo kusintha kwake kumachitika kale kuposa CRP. Malingana ndi zotsatira za kafukufuku, mlingo wa IL-6 umakula mofulumira pa matenda a bakiteriya, mlingo wa PCT umawonjezeka pambuyo pa 2h, pamene CRP imangowonjezeka mofulumira pambuyo pa 6h. Katulutsidwe kosazolowereka kapena mawonekedwe a jini a IL-6 nthawi zambiri amatha kupangitsa kuti pakhale matenda angapo, kuchuluka kwa IL-6 kumatha kutulutsidwa m'magazi amtundu wa pathological state, ndipo kuzindikira kwa IL-6 ndikofunikira kwambiri pakuzindikira matenda komanso kuzindikira kwamtsogolo.