Interleukin-6 ndi polypeptide yomwe imakhala ndi unyolo wa glycoprotein awiri, womwe uli ndi kulemera kwa mamolekyulu a 130kd. Monga membala wofunikira wa netiweki ya cytokine, interleukin-6 (IL-6) imagwira ntchito yayikulu pakuyambitsa kutupa kwadzidzidzi, ndipo imatha kuyambitsa kusintha kwa chiwindi, ndikulimbikitsa kupanga puloteni ya C-reactive (CRP) ndi fibrinogen. Matenda ambiri opatsirana angayambitse kukwera kwa IL-6 m'magazi, ndipo IL-6 imagwirizanitsidwa kwambiri ndi zotsatira za odwala. Monga cytokine ya pleiotropic yokhala ndi ntchito zambiri, IL-6 imatulutsidwa ndi T cell, B cell, mononuclear phagocyte, ndi endothelial cell, ndipo ndi gawo lofunika kwambiri la netiweki yolumikizira kutupa. Pakachitika kutupa, IL-6 imapangidwa koyamba, zomwe zimapangitsa kupanga CRP ndi procalcitonin (PCT) ikapangidwa. Idzapangidwa mwachangu ngati pali matenda, kuvulala mkati ndi kunja, opaleshoni, kupsinjika, kufa kwa ubongo, kutuluka kwa tumorigenesis, ndi njira yodziwira kutupa kwadzidzidzi pazinthu zina. IL-6 imagwira ntchito pakukula ndi kufalikira kwa matenda ambiri, kuchuluka kwa magazi ake kumalumikizidwa kwambiri ndi kutupa, matenda opatsirana ndi kachilombo, komanso matenda odziyimira pawokha, ndipo kusintha kwake kumachitika CRP isanakwane. Malinga ndi zotsatira za kafukufuku, kuchuluka kwa IL-6 kumawonjezeka mwachangu pakadwala matenda a bakiteriya, kuchuluka kwa PCT kumawonjezeka pakatha maola awiri, pomwe CRP imawonjezeka mwachangu pakatha maola 6. Kutulutsa kosazolowereka kapena kufalikira kwa majini a IL-6 nthawi zambiri kungayambitse matenda angapo, kuchuluka kwa IL-6 kumatha kutulutsidwa m'magazi mukakhala ndi vuto la matenda, ndipo kuzindikira IL-6 ndikofunikira kwambiri pakupeza matenda ndi kuweruza zamtsogolo.