Mgwirizano Pakati pa Kutupa, Kukalamba, ndi Matenda a Alzheimer's

M'zaka zaposachedwa, ubale pakati pa gut microbiota ndi matenda amisempha wakhala malo ofufuza. Umboni wochulukirachulukira ukuwonetsa kuti kutupa kwamatumbo (monga kutayikira m'matumbo ndi dysbiosis) kumatha kukhudza kukula kwa matenda a neurodegenerative, makamaka matenda a Alzheimer's (AD), kudzera mu "matumbo a ubongo". Nkhaniyi ikufotokoza momwe kutupa kwa m'mimba kumakulirakulira ndi zaka ndikuwunika momwe angagwirizanitse ndi AD pathology (monga β-amyloid deposition ndi neuroinflammation), kupereka malingaliro atsopano a kulowererapo koyambirira kwa AD.

1. Mawu Oyamba

Matenda a Alzheimer's (AD) ndi matenda a neurodegenerative, omwe amadziwika ndi zolembera za β-amyloid (Aβ) ndi mapuloteni a hyperphosphorylated tau. Ngakhale kuti majini (mwachitsanzo, APOE4) ndizomwe zimayambitsa chiwopsezo cha AD, zokokera zachilengedwe (mwachitsanzo, zakudya, thanzi lamatumbo) zithanso kuthandizira kukula kwa AD kudzera mu kutupa kosatha. M'matumbo, monga chiwalo chachikulu cha chitetezo cha mthupi, amatha kukhudza thanzi laubongo kudzera m'njira zingapo, makamaka akamakalamba.

2. Kutupa M'matumbo ndi Kukalamba

2.1 Kutsika kokhudzana ndi zaka za ntchito yotchinga matumbo
Ndi zaka, umphumphu wa matumbo a m'mimba umachepa, zomwe zimapangitsa kuti "kutuluka m'matumbo", kulola kuti ma metabolites a bakiteriya (monga lipopolysaccharide, LPS) alowe m'magazi, zomwe zimayambitsa kutupa kwadongosolo. Kafukufuku wasonyeza kuti kusiyanasiyana kwa zomera za m'mimba mwa okalamba kumachepa, mabakiteriya oyambitsa kutupa (monga Proteobacteria) amawonjezeka, ndipo mabakiteriya odana ndi kutupa (monga Bifidobacterium) amachepetsa, ndikuwonjezera kuyankha kotupa.

2.2 Zinthu zotupa komanso ukalamba
Kutupa kwanthawi yayitali ("kukalamba kotupa", Kutupa) ndikofunikira kwambiri pakukalamba. Zinthu zotupa zam'mimba (mongaIL-6, TNF-α) imatha kulowa muubongo kudzera mukuyenda kwa magazi, kuyambitsa microglia, kulimbikitsa neuroinflammation, ndikufulumizitsa njira ya pathological ya AD.

ndi kulimbikitsa neuroinflammation, potero kumathandizira matenda a AD.

3. Ubale Pakati pa Kutupa M'matumbo ndi Matenda a Alzheimer's

3.1 Gut Dysbiosis ndi Aβ Deposition

Zitsanzo za zinyama zasonyeza kuti kusokonezeka kwa zomera za m'mimba kumatha kuonjezera kuyika kwa Aβ. Mwachitsanzo, mbewa zothandizidwa ndi maantibayotiki zachepetsa ma Aβ plaques, pomwe milingo ya Aβ imachulukitsidwa mu mbewa zokhala ndi dysbiosis. Ma metabolites ena a bakiteriya (monga ma chain-chain fatty acids, SCFAs) angakhudze chilolezo cha Aβ poyendetsa ntchito ya microglial.

3.2 The Gut-Brain Axis ndi Neuroinflammation

Kutupa kwamatumbo kumatha kukhudza ubongo kudzera mu vagal, chitetezo chamthupi, ndi njira zama metabolic:

• Vagal pathway: zizindikiro zotupa m'mimba zimafalitsidwa kudzera mu mitsempha ya vagus kupita ku CNS, zomwe zimakhudza hippocampal ndi prefrontal cortex function.
• Kutupa kwadongosolo: Zigawo za mabakiteriya monga LPS zimayendetsa microglia ndikulimbikitsa neuroinflammation, kukulitsa tau pathology ndi kuwonongeka kwa neuronal.
• Zotsatira za metabolic: m'matumbo dysbiosis imatha kukhudza kagayidwe ka tryptophan, zomwe zimapangitsa kusalinganika kwa ma neurotransmitters (mwachitsanzo, 5-HT) komanso kukhudza chidziwitso.

3.3 Umboni Wachipatala

• Odwala omwe ali ndi AD ali ndi mitundu yosiyanasiyana ya m'matumbo kuposa achikulire athanzi, mwachitsanzo, kuchuluka kwa Thick-walled phylum/Antibacterial phylum.
• Magazi a LPS amalumikizana bwino ndi kuuma kwa AD.
• Kulowererapo kwa ma probiotic (mwachitsanzo, Bifidobacterium bifidum) kumachepetsa kuyika kwa Aβ ndikuwongolera magwiridwe antchito azidziwitso zanyama.

4. Njira Zothandizira Zomwe Zingatheke

Kusintha kwa zakudya: zakudya zamtundu wambiri, zakudya za ku Mediterranean zingalimbikitse kukula kwa mabakiteriya opindulitsa komanso kuchepetsa kutupa.

1. Ma Probiotic / Prebiotics: Kuphatikizika ndi mitundu ina ya mabakiteriya (mwachitsanzo, Lactobacillus, Bifidobacterium) kumatha kupititsa patsogolo ntchito yotchinga m'matumbo.
2. Mankhwala oletsa kutupa: mankhwala omwe amalimbana ndi kutupa m'matumbo (mwachitsanzo, TLR4 inhibitors) amatha kuchedwetsa kukula kwa AD.
3. Zochita pa moyo: zolimbitsa thupi komanso kuchepetsa nkhawa zimatha kusunga m'matumbo

5. Mapeto ndi Malingaliro amtsogolo

Kutupa m'matumbo kumawonjezeka ndi zaka ndipo kumatha kuyambitsa matenda a AD kudzera munjira yaubongo. Kafukufuku wamtsogolo akuyenera kumveketsa bwino ubale woyambitsa pakati pa zomera zinazake ndi AD ndikuwunikanso njira zopewera AD komanso njira zochizira potengera malamulo a m'matumbo. Kafukufuku m'derali atha kupereka mipherezero yatsopano pakulowererapo koyambirira kwa matenda a neurodegenerative.

Xiamen Baysen Medical We Baysen Medical nthawi zonse imayang'ana kwambiri njira zowunikira kuti moyo ukhale wabwino. Tapanga nsanja 5 zaukadaulo- Latex, golide wa colloidal, Fluorescence Immunochromatographic Assay, Molecular,Chemiluminescence Immunoassay. Timaganizira za thanzi lathu, komanso thanzi lathumayeso a CAL amagwiritsidwa ntchito kuzindikira kutupa m'matumbo.

Zolozera :

1. Vogt, NM, et al. (2017). "Gut microbiome zosintha mu matenda a Alzheimer's."Malipoti a Sayansi.
2. Dodiya, HB, et al. (2020). "Kutupa kwamatumbo kosatha kumakulitsa matenda a tau mumtundu wa mbewa wa matenda a Alzheimer's."Nature Neuroscience.
3. Franceschi, C., et al. (2018). "Kutupa: lingaliro latsopano la chitetezo chamthupi la matenda okhudzana ndi ukalamba."Nature Reviews Endocrinology.