Ferritin: Biomarker Yofulumira komanso Yolondola Yowunikira Kuperewera kwa Iron ndi Kuperewera kwa magazi

Mawu Oyamba

Kuperewera kwa iron ndi kuchepa kwa magazi m'thupi ndizovuta zathanzi padziko lonse lapansi, makamaka m'maiko omwe akutukuka kumene, amayi apakati, ana ndi amayi azaka zakubadwa. Iron Deficiency anemia (IDA) sikuti imakhudza thupi ndi chidziwitso cha anthu, komanso imatha kuonjezera chiopsezo cha mimba komanso kuchedwa kwa chitukuko cha ana. Chifukwa chake, kuyezetsa koyambirira ndi kuchitapo kanthu ndikofunikira. Pakati pa zizindikiro zambiri zozindikiritsa, ferritin yakhala chida chofunikira chowunikira kuchepa kwachitsulo ndi kuchepa kwa magazi m'thupi chifukwa cha kukhudzidwa kwake kwakukulu komanso kutsimikizika. Nkhaniyi ifotokoza zachilengedwe za ferritin, zabwino zake pakuzindikira kusowa kwachitsulo ndi kuchepa kwa magazi m'thupi, komanso kufunika kwake kwachipatala.

Biological Makhalidwe aFerritin

Ferritinndi puloteni yosungira chitsulo yomwe imapezeka kwambiri m'matumbo a anthu. Amapangidwa makamaka ndi chiwindi, ndulu ndi mafupa. Ntchito yake yayikulu ndikusunga chitsulo ndikuwongolera kagayidwe kachitsulo. M'magazi, ndende yaferritinzimagwirizana bwino ndi zitsulo zosungidwa m'thupi. Chifukwa chake, seramuferritinmisinkhu ndi chimodzi mwa zizindikiro tcheru kwambiri thupi chitsulo posungira. Nthawi zambiri, mlingo wa ferritin mwa amuna akuluakulu ndi pafupifupi 30-400 ng / mL, ndipo mwa akazi ndi 15-150 ng / mL, koma pakakhala kusowa kwachitsulo, mtengowu udzachepetsedwa kwambiri.

Ubwino waFerritinmu Kuwunika Kuperewera kwa Iron

1. Kukhudzika kwakukulu, kuzindikira msanga kusowa kwachitsulo

Kukula kwa iron akusowa kugawidwa m'magawo atatu:

• Gawo la kuchepa kwachitsulo: chitsulo chosungira(ferritin) amachepetsa, koma hemoglobin ndi wabwinobwino;
• Iron deficiency erythropoiesis stage:ferritinamachepetsanso, machulukitsidwe a transferrin amachepetsa;
• Iron akusowa magazi m`thupi siteji: hemoglobin amachepetsa, ndi mmene zizindikiro magazi m`thupi kuonekera.

Njira zowunikira zachikhalidwe (monga kuyezetsa hemoglobin) zitha kuzindikira zovuta mugawo la kuchepa kwa magazi, pomweferritinkuyezetsa kumatha kuzindikira zolakwika mu gawo loyambirira la kusowa kwachitsulo, motero kumapereka mwayi wochitapo kanthu mwachangu.

2. Kudziwika Kwambiri, Kuchepetsa Kusazindikira

Matenda ambiri (monga kutupa kosatha ndi matenda) angayambitse kuchepa kwa magazi m'thupi, koma samayamba chifukwa cha kusowa kwachitsulo. Pachifukwa ichi, kudalira hemoglobini yokha kapena kutanthawuza corpuscular volume (MCV) kungaganizire molakwika chifukwa chake.Ferritinkuyezetsa kungathe kusiyanitsa molondola kuchepa kwachitsulo kwa kuchepa kwa magazi m'thupi ndi mitundu ina ya kuchepa kwa magazi (monga kuchepa kwa magazi m'thupi la matenda aakulu), kukonza kulondola kwa matenda.

3. Zofulumira komanso zosavuta, zoyenera kuwunikira kwakukulu

Ukadaulo wamakono woyezera zamankhwala am'thupi umapangitsa kutsimikiza kwa ferritin kukhala kosavuta komanso kopanda ndalama zambiri, ndipo ndi koyenera pama projekiti azaumoyo wa anthu monga kuyezetsa anthu ammudzi, chisamaliro chaumoyo wa amayi ndi makanda, komanso kuyang'anira zakudya za ana. Poyerekeza ndi mayeso owopsa monga chitsulo chachitsulo chamafuta (golide), kuyesa kwa serum ferritin ndikosavuta kulimbikitsa.

Ntchito Zachipatala za Ferritin mu Anemia Management

1. Chithandizo chachitsulo chowongolera

Ferritinmilingo ingathandize madokotala kudziwa ngati odwala akufunika chitsulo chowonjezera ndikuwona momwe chithandizo chikuyendera. Mwachitsanzo:

• Ferritin<30 ng/mL: imasonyeza kuti nkhokwe zachitsulo zatha ndipo zitsulo zowonjezera zimafunikira;
• Ferritin<15 ng/mL: zimasonyeza kwambiri chitsulo kuchepa magazi m'thupi;
• Chithandizo chikagwira ntchito, ferritin Miyezo idzakwera pang'onopang'ono ndipo ingagwiritsidwe ntchito kuyesa mphamvu

1. Zowonjezera Iron Yotsogolera

FerritinMiyezo imathandiza asing'anga kudziwa kufunikira kwa chithandizo chachitsulo ndikuwunika momwe chithandizo chimagwirira ntchito. Mwachitsanzo:

• Ferritin<30 ng/mL: Imawonetsa masitolo achitsulo atha, omwe amafunikira zowonjezera.
• Ferritin<15 ng/mL: Imawonetsa kwambiri kuchepa kwachitsulo m'magazi.
• Pa chithandizo, kukweraferritinmilingo imatsimikizira kuchiritsa kwamphamvu.

2. Kuwunika anthu apadera

• Amayi oyembekezera: kufunikira kwachitsulo kumawonjezeka pa nthawi ya mimba, ndiferritinkuyezetsa kungalepheretse zovuta za amayi ndi makanda.
• Ana: kusowa kwachitsulo kumakhudza kukula kwachidziwitso, ndipo kuyang'ana koyambirira kungathandize kuti matendawa atheke.
• Odwala omwe ali ndi matenda aakulu: monga odwala matenda a impso ndi matenda opweteka a m'mimba,ferritin kuphatikiza transferrin machulukitsidwe akhoza kuzindikira mtundu wa magazi m'thupi.

Zochepa zaFerritinMayeso ndi Mayankho

Ngakhale kuti ferritin ndiye chizindikiro chomwe chimakondedwa pakuwunika kwa chitsulo, chiyenera kutanthauziridwa mosamala nthawi zina:

• Kutupa kapena matenda:Ferritin, monga pachimake gawo reactant mapuloteni, akhoza zabodza okwera mu matenda, chotupa kapena kutupa aakulu. Pankhaniyi, ikhoza kuphatikizidwa ndiC-reactive protein (CRP) ortransferrinkukhutitsidwa kwa chiweruzo chokwanira.
• Matenda a chiwindi:Ferritinodwala matenda enaake akhoza kuwonjezeka chifukwa chiwindi kuwonongeka maselo ndipo ayenera kuunika pamodzi ndi zina chitsulo kagayidwe zizindikiro.

Mapeto

Ferritinkuyezetsa kwakhala chida chofunikira chowunikira kuchepa kwachitsulo ndi kuchepa kwa magazi m'thupi chifukwa cha chidwi chake, kukhazikika komanso kusavuta. Iwo sangakhoze kuzindikira chitsulo akusowa msanga ndi kupewa kupitirira kwa magazi m`thupi, komanso kutsogolera yolondola mankhwala ndi kusintha odwala matenda. Pazaumoyo wa anthu ndi machitidwe azachipatala, kukwezedwa kwaferritin kuyezetsa kungathandize kuchepetsa kulemedwa kwa matenda a iron deficiency anemia, makamaka kwa magulu omwe ali pachiopsezo chachikulu (monga amayi apakati, ana ndi odwala matenda aakulu). M'tsogolomu, ndi kupita patsogolo kwa ukadaulo wozindikira,ferritin atha kutenga gawo lalikulu pakupewa komanso kuwongolera kuchepa kwa magazi m'thupi.

We Baysen Medical nthawi zonse timayang'ana kwambiri njira zodziwira matenda kuti tikhale ndi moyo wabwino. Tapanga nsanja 5 zaukadaulo- Latex, golide wa colloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, YathuZoyeserera za Ferritin ntchito yosavuta ndipo mutha kupeza zotsatira zoyeserera mu mphindi 15