Kuzindikira Molondola, Kuteteza Thanzi la M'mimba: Mayankho Oyesera a H. pylori Omwe Alipo

Helicobacter pylori (H. pylori)Bungwe la World Health Organization limaika chizindikiro cha khansa ya m'thupi ya Gulu I ndipo ndi chinthu chachikulu chomwe chimayambitsa matenda a gastritis osatha, zilonda zam'mimba, komanso khansa ya m'mimba. Popeza kuchuluka kwa matenda m'madera ambiri kuli kwakukulu, kuyezetsa koyambirira ndi kuzindikira matenda molondola ndikofunikira kwambiri popewa ndikuwongolera matenda am'mimba. Monga kampani yodziwitsa zachipatala, timapereka mayeso athunthu - kuyambira kuyezetsa koyambirira mpaka kuyezetsa kolondola - kuti tikwaniritse zosowa zosiyanasiyana zachipatala komanso kuyezetsa.

Kuwunika Moyenera: Kuyesa Mpweya ndi Zothandizira Mwachangu

Pa kuyezetsa thanzi lalikulu komanso kuyezetsa odwala osapita kuchipatala, C13/C14Mayeso a Mpweya wa Ureaimadziwika padziko lonse lapansi ngati muyezo wagolide wopezera matenda a H. pylori, kupereka mayeso osavulaza molondola kuposa 95%. C13 isotope siigwiritsa ntchito ma radiation ndipo ndi yoyenera anthu onse, kuphatikizapo amayi apakati ndi ana, pomwe mayeso a C14 amapereka njira ina yotsika mtengo komanso yothandiza.

Mofananamo, timapereka njira yabwinoHP-AB (antibody)ndiZida zoyesera za HP-AG (antigen) mwachangu. TheHP-ABKuyesaku kumapeza ma antibodies pogwiritsa ntchito magazi kapena seramu ya chala, zomwe zimabweretsa zotsatira mkati mwa mphindi 15—zabwino kwambiri pa kafukufuku wa matenda.Mayeso a HP-AGImazindikira ma antigen m'masampuli a ndowe, zomwe zimasonyeza mwachindunji momwe matenda alili. Imagwira ntchito ngati chowonjezera chothandiza pa mayeso a mpweya, makamaka othandiza kwa anthu ena omwe mayeso ena angakhale ovuta.

Kuyeza Kolondola: Ukadaulo wa Kuyeza kwa Mphamvu ya Mthupi

Kuti tikwaniritse zosowa zachipatala zowunikira matenda ndi kuwunika momwe mankhwala amathandizira, tayambitsa ma reagents ochulukitsa a HP-AG ndi HP-AB omwe amayendetsedwa ndiWIZ-101ndiWIZ-A203mapulatifomu. Dongosololi limagwiritsa ntchito nthawi yokhazikika yowunikira ma immunochromatography, kuphatikiza ma antibodies enaake ndi ma microspheres a fluorescent. Mosiyana ndi mizere yoyesera yachikhalidwe, ukadaulo uwu umathandizira kuyeza molondola kuchuluka kwa ma antibodies/antigen. Izi sizimangothandiza madokotala kuwunika kuopsa kwa matenda komanso zimathandiza kuwunika molondola zotsatira za chithandizo chothetsera matenda, kupereka deta yodalirika kwambiri popanga zisankho zachipatala.

Kuyambira kuyesa mpweya pogwiritsa ntchito mass spectrometry mpaka immunochromatography, komanso kuyambira pakuwunika kwa qualitative mpaka pa fluorescence-based quantity, tadzipereka kupereka zinthu zambiri zomwe zimathandiza mabungwe azaumoyo kuti azitha kupewa ndi kuwongolera matenda a H. pylori m'mimba.