C-Reactive Protein (CRP) ndi mapuloteni opangidwa ndi chiwindi, ndipo milingo yake m'magazi imakwera kwambiri chifukwa cha kutupa. Kupezeka kwake mu 1930 komanso kafukufuku wotsatira walimbitsa udindo wake ngati imodzi mwazinthu zofunika kwambiri komanso zogwiritsidwa ntchito kwambiri pazamankhwala amakono. Kufunika kwa kuyezetsa kwa CRP kwagona pakugwiritsa ntchito kwake ngati chizindikiro chodziwikiratu, ngakhale chosatchulika, cha kutupa, kuthandizira kuzindikira, kusanja kwachiwopsezo, komanso kuwunika zinthu zambiri.

1. Chizindikiro Chomvera Pamatenda ndi Kutupa
Chimodzi mwazinthu zofunika kwambiri za CRP ndikuzindikira ndi kuyang'anira matenda, makamaka matenda oyambitsidwa ndi mabakiteriya. Ngakhale kukwera kwa CRP ndikuyankhira kwa kutupa, milingo imatha kukwera m'matenda oopsa a bakiteriya, nthawi zambiri kuposa 100 mg/L. Izi zimapangitsa kukhala kofunikira pakusiyanitsa mabakiteriya ndi matenda obwera chifukwa cha ma virus, chifukwa omalizawa amayambitsa kukwera kocheperako. M'malo azachipatala, CRP imagwiritsidwa ntchito pozindikira matenda monga chibayo, sepsis, komanso matenda obwera pambuyo pa opaleshoni. Mwachitsanzo, kuyang'anira CRP pambuyo pa opaleshoni kumathandiza madokotala kuzindikira zovuta monga matenda a bala kapena zotupa zakuya mofulumira, zomwe zimathandiza kuti athandizidwe mwamsanga. Zimathandizanso kuthana ndi matenda otupa osatha monga nyamakazi ya nyamakazi ndi matenda otupa a m'matumbo (IBD), komwe kuyeza kwanthawi yayitali kumathandiza kudziwa momwe matenda amagwirira ntchito komanso mphamvu ya anti-inflammatory therapy.

2. Kuwunika Kuopsa kwa Mitsempha ya Mitsempha: hs-CRP
Kupita patsogolo kwakukulu m'munda kunali kupititsa patsogolo kuyesa kwa CRP (hs-CRP). Mayesowa amayesa milingo yotsika kwambiri ya CRP, yomwe poyamba inali yosazindikirika. Kafukufuku wasonyeza kuti kutupa kosalekeza, kochepa kwambiri m'kati mwa makoma a mitsempha ndizomwe zimayambitsa matenda a atherosclerosis - kupangika kwa plaque komwe kungayambitse matenda a mtima ndi zikwapu. hs-CRP imagwira ntchito ngati chizindikiro cholimba cha kutupa kwa mitsempha iyi.
American Heart Association imazindikira hs-CRP ngati chinthu chodziyimira pawokha cha matenda amtima. Anthu omwe ali ndi milingo ya hs-CRP pamlingo wapamwamba kwambiri (pamwamba pa 3 mg / L) amawonedwa kuti ali pachiwopsezo chowonjezereka cha zochitika zapamtima zamtsogolo, ngakhale ma cholesterol awo ali abwinobwino. Chifukwa chake, hs-CRP imagwiritsidwa ntchito kuwongolera kuwunika kowopsa, makamaka kwa odwala omwe ali pachiwopsezo chapakati. Izi zimalola kuti pakhale njira zodzitetezera, monga kuyambitsa chithandizo cha statin mwa anthu omwe mwina sangalandire chithandizo kutengera zomwe zingayambitse ngozi.

3. Kuyang'anira Kuyankha kwa Chithandizo ndi Zomwe Zachitika
Kupatula kuwunika komanso kuunika kwachiwopsezo, CRP ndi chida chabwino kwambiri chowonera momwe wodwalayo akuyankhira chithandizo. M'matenda opatsirana, kugwa kwa CRP ndi chizindikiro champhamvu kuti maantibayotiki kapena antimicrobial therapy ndi othandiza. Momwemonso, m'mikhalidwe ya autoimmune, kuchepa kwa CRP kumagwirizana ndi kupondereza bwino kwa kutupa ndi mankhwala ochepetsa thupi. Chikhalidwe chosinthikachi chimalola asing'anga kusintha mapulani amankhwala munthawi yeniyeni. Kuphatikiza apo, milingo yayikulu ya CRP nthawi zambiri imalumikizidwa ndi vuto loyipa kwambiri kuyambira pa khansa mpaka kulephera kwa mtima, zomwe zimawonetsa kuopsa kwa matendawa.

Zolepheretsa ndi Mapeto
Ngakhale ndizothandiza, cholepheretsa chachikulu cha CRP ndichopanda tanthauzo lake. Mlingo wokwera umasonyeza kukhalapo kwa kutupa koma sikutchula chifukwa chake. Kupsinjika maganizo, kupwetekedwa mtima, kunenepa kwambiri, ndi matenda aakulu akhoza kukweza CRP. Choncho, zotsatira zake ziyenera kutanthauziridwa nthawi zonse ponena za mbiri yachipatala ya wodwala, kuyezetsa thupi, ndi zina zomwe zapezeka.

Pomaliza, kufunikira kwa kuyesa kwa CRP ndikosiyanasiyana. Kuchokera pakuchita ngati mayeso akutsogolo a matenda owopsa mpaka kukhala cholosera chambiri cha chiopsezo chamtima kwanthawi yayitali kudzera mu hs-CRP, chizindikiro ichi ndi chida chofunikira kwambiri pagulu lankhondo lachipatala. Kuthekera kwake kuyeza ndi kuyang'anira kutupa kwathandizira kwambiri chisamaliro cha odwala pakuzindikira, kuwongolera chithandizo, komanso kuwunika kwamtsogolo pazachipatala zambiri.