Iriburiro: Akamaro k’amavuriro yo kugenzura imikorere yimpyiko hakiri kare ：

Indwara idakira y'impyiko (CKD) yabaye ikibazo cy’ubuzima rusange ku isi. Imibare yatanzwe n’umuryango w’ubuzima ku isi ivuga ko abantu bagera kuri miliyoni 850 ku isi barwaye indwara z’impyiko, kandi ku isi hose indwara z’impyiko zidakira zigera kuri 9.1%. Igikomeye cyane ni uko indwara zimpyiko zidakira hakiri kare nta bimenyetso bigaragara bigaragara, bigatuma umubare munini wabarwayi babura igihe cyiza cyo gutabara. Kuruhande rwibi,microalbuminuria, nk'ikimenyetso cyerekana kwangirika kw'impyiko hakiri kare, cyarushijeho kugira agaciro. Uburyo bwa gakondo bwo gupima imikorere yimpyiko nka serumu creatinine hamwe nigipimo cyo kugereranya isi yose (eGFR) bizerekana gusa ibintu bidasanzwe mugihe imikorere yimpyiko yatakaye hejuru ya 50%, mugihe kwipimisha alubumu yinkari bishobora gutanga ibimenyetso byo kuburira hakiri kare mugihe imikorere yimpyiko yatakaye 10-15%.

Agaciro kamavuriro nuburyo bugezweho bwaALBkwipimisha inkari

Albumin (ALB) ni poroteyine nyinshi mu nkari z'abantu bafite ubuzima bwiza, hamwe n'igipimo gisanzwe cyo gusohoka kiri munsi ya 30mg / 24h. Iyo igipimo cyo gusohora alubumu yinkari kiri hagati ya 30-300mg / 24h, bisobanurwa nka microalbuminuria, kandi iki cyiciro nigihe cyamadirishya ya zahabu yo gutabara kugirango ihindure impyiko. Kugeza ubu, ibisanzwe bikoreshwaALBuburyo bwo gutahura mubikorwa byubuvuzi harimo radioimmunoassay, enzyme ihujwe na immunosorbent assay (ELISA), immunoturbidimetry, nibindi, ariko ubu buryo muri rusange bufite ibibazo nkibikorwa bigoye, kumara igihe kinini, cyangwa gukenera ibikoresho byihariye. Cyane cyane kubigo byubuvuzi byibanze hamwe no gukurikirana urugo, tekinoroji ihari iragoye guhaza ibikenewe byoroheje, umuvuduko, nukuri, bigatuma umubare munini wabarwayi bafite impyiko hakiri kare batavumburwa mugihe.

Iterambere Rishya Muburyo BwuzuyeALB Ikizamini CyinkariReagent

Mu gusubiza imbogamizi zikoranabuhanga risanzweho, isosiyete yacu yateje imbere PrecisionALB Ikizamini Cyinkari Reagent kugirango umenye umubare witerambere ryikoranabuhanga. Reagent ikoresha tekinoroji ya immunochromatografique yateye imbere kandi ifite umwihariko wo kurwanya antibody ya monoclonal anti-muntu kugira ngo ikizamini gikemuke kandi cyizewe. Guhanga udushya bigaragarira cyane cyane mubice bitatu:

• Byagaragaye cyane kubyunvikana: imipaka yo hasi yo gutahura igera kuri 2mg / L, kandi irashobora kumenya neza inkari yinkari ya microalbumin ya 30mg / 24h, ibyo bikaba byiza cyane kuruta ibyiyumvo byibizamini gakondo.
• Kongera ubushobozi bwo kurwanya-kwivanga: Binyuze mu gishushanyo cyihariye cya sisitemu ya buffer, irashobora gutsinda neza ihindagurika ry’imihindagurikire y’inkari pH, ihinduka ry’ingufu za ionic hamwe n’ibindi bintu ku bisubizo by’ibizamini, bigatuma ikizamini gihoraho mu bihe bitandukanye bya fiyologiki.
• Kugaragaza udushya twinshi: umusomyi udasanzwe ushyigikiwe arashobora kumenya igice cyumubare kugeza kumubare wuzuye, urwego rwo gutahura rufite 0-200mg / L, kugirango uhuze ibyifuzo bitandukanye byubuvuzi kuva kwipimisha kugeza kubikurikirana.

Imikorere y'ibicuruzwa nibyiza

Ivuriro ryemewe mubitaro byinshi bya kaminuza, iyi reagent yerekana ibipimo byiza. Ugereranije na zahabu isanzwe yamasaha 24 yinkari za alubumu, coeffisente ihuriro igera kuri 0,98; coefficient zo hagati-na-batch zo gutandukana ziri munsi ya 5%, munsi cyane ugereranije ninganda; igihe cyo gutahura ni iminota 15 gusa, itezimbere cyane imikorere yubuvuzi. Ibyiza byibicuruzwa byavuzwe muri make:

• Ubworoherane bwibikorwa: ntibikenewe mbere yo kuvurwa bigoye, ingero zinkari zirashobora kuba kuri sample, ibikorwa byintambwe eshatu kugirango urangize ikizamini, abatari abanyamwuga barashobora kumenya nyuma y amahugurwa make.
• Ibisubizo byimbitse: ikoreshwa rya sisitemu isobanutse yiterambere rya sisitemu, ijisho ryonyine rishobora gusomwa muburyo bwambere, guhuza amakarita yamabara arashobora kuba igice cyisesengura, kugirango uhuze ibikenewe muburyo butandukanye.
• Ubukungu kandi bunoze: ikiguzi cyikizamini kimwe kiri hasi cyane ugereranije nibizamini bya laboratoire, bikwiranye no kwipimisha binini no gukurikirana igihe kirekire, kandi bifite agaciro gakomeye mubukungu.

• Agaciro ko kuburira hakiri kare: kwangirika kwimpyiko birashobora kumenyekana mbere yimyaka 3-5 ugereranije nibikorwa bisanzwe byimpyiko, bigatsinda umwanya wingenzi wo kwivuza.

Ikoreshwa rya Clinical scenarios hamwe nibyifuzo byubuyobozi

IcyitonderwaALB Urine Testifite intera nini yo gusaba ibintu. Mu rwego rwa diyabete mellitus, amabwiriza y’ishyirahamwe ry’abanyamerika Diyabete (ADA) arasaba neza ko abarwayi bose barwaye diyabete yo mu bwoko bwa 1 ≥ imyaka 5 n’abarwayi bose barwaye diyabete yo mu bwoko bwa 2 bagomba kwipimisha inkari buri mwaka. Mu micungire ya hypertension, amabwiriza ya hypertension ya ESC / ESH yerekana microalbuminuria nkikimenyetso cyingenzi cyangirika kwingingo. Byongeye kandi, reagent ikwiranye nibintu byinshi nko gusuzuma ibyago byindwara z'umutima-damura, gusuzuma imikorere yimpyiko kubasaza, no gukurikirana impyiko mugihe utwite.

By'umwihariko inyungu ni uko iki gicuruzwa gihuye neza nibikenewe byo gusuzuma no kuvura. Irashobora gukoreshwa nkigikoresho cyiza cyo gusuzuma indwara zimpyiko mubigo byubuvuzi bwibanze nkibitaro byabaturage n’ibigo nderabuzima byo mu mujyi; mu ishami rya neprologiya na endocrinology ishami ryibitaro rusange, irashobora gukoreshwa nkigikoresho cyingenzi cyo gucunga indwara no gukurikirana imikorere; mu bigo nderabuzima, birashobora kwinjizwa mu bikoresho byo gusuzuma ubuzima kugira ngo byongere igipimo cyo kumenya ibikomere by'impyiko hakiri kare; ndetse biteganijwe ko yinjira mumasoko yo gukurikirana ubuzima bwumuryango nyuma yo kwemezwa ejo hazaza.

Umwanzuro

Twebwe ubuvuzi bwa Baysen buri gihe twibanda kubuhanga bwo gusuzuma kugirango tuzamure ubuzima. Twateje imbere tekinoroji 5 yikoranabuhanga- Latex, zahabu ya colloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay.TufiteIkizamini cya ALB FIA Gukurikirana ibikomere byimpyiko hakiri kare