Isano iri hagati y'umwijima ubyibushye n' Insulini

Isano iri hagati y'umwijima w'ibinure n'umusemburo wa insuline urimo glycated ni isano ya hafi iri hagati y'umwijima w'ibinure (cyane cyane indwara y'umwijima w'ibinure udakoresheje inzoga, NAFLD) nainsuline(cyangwainsulinekurwanya indwara, hyperinsulinemia), iterwa ahanini n'ibibazo by'imikorere y'umubiri (urugero: umubyibuho ukabije, ubwoko bwa 2diyabete,nibindi). Ibi bikurikira ni isesengura ryimbitse ry'ingingo z'ingenzi:

1. InsuliniUbudahangarwa nk'uburyo bw'ibanze

• InsuliniUbudahangarwa bw'umubiri (IR) ni ishingiro risanzwe ry'indwara z'umwijima w'ibinure n'imikorere mibi ya glucose. Iyo umubiri ubasha kumva insuline igabanutse, pancreas isohora byinshi mu buryo bw'ikiguzi.insuline(hyperinsulinemia), bigatuma urugero rwa insuline mu maraso rwiyongera.
• Ingaruka z'umwijima w'ibinure: umwijimainsulineUbudahangarwa bubuza ogisijeni y’aside irike, bugatuma ibinure byiyongera (ibinure bishyirwa mu mubiri), kandi bugatuma ibinure byiyongera mu ihinduka ry’uturemangingo (steatosis).
• Kwifatanya naHbA1cNubwo insuline ikoresha glycated atari ikimenyetso gikunze gukoreshwa mu buvuzi, hyperglycemia ihoraho (ifitanye isano na IR) yongera hemoglobine ikoresha glycated(HbA1c), bigaragaza ko isukari yo mu maraso idakora neza, ibyo bikaba bifitanye isano no kwiyongera kw'umwijima w'ibinure bikagera kuri steatohepatitis idashingiye ku nzoga (NASH).

2. Hyperinsulinemia itera indwara y'umwijima w'ibinure

• Igikorwa kitaziguye: Hyperinsulinemia itera lipogenesis mu mwijima (↑ lipid synthesis) binyuze mu gukora transcription factors (urugero: SREBP-1c) mu gihe bibuza aside β-oxidation y'ibinure.
• Ingaruka zitaziguye:InsuliniUbudahangarwa butuma ingirabuzimafatizo z'amafuta zirekura aside nyinshi z'ibinure (FFAs), zinjira mu mwijima zigahinduka triglycerides, bigatuma umwijima w'ibinure urushaho kwiyongera.

3. Umwijima w'ibinure wongera imikorere mibi ya glucose

• Biterwa n'umwijimaInsuliniUbudahangarwa: Umwijima w'ibinure urekura cytokines zitera ubushyuhe (urugero: TNF-α,IL-6) na adipokines (urugero, ubudahangarwa bwa leptin, kugabanuka kwa adiponectin), birushaho kugabanya ubudahangarwa bwa insuline mu mubiri.
• Kongera umusaruro wa glucose mu mwijima:insulineUbudahangarwa butuma umwijima udashobora gukumira gluconeogenesis neza, kandi isukari nyinshi mu maraso yihuta birushaho kwangiza imikorere y’isukari (bishoboka ko igera kuri diyabete yo mu bwoko bwa 2).

4. Ibimenyetso by'ubuvuzi:Hemoglobini ya Glycosylated (HbA1c)n'umwijima w'ibinure

• HbA1c iri hejuru iteganya ibyago by'umwijima w'ibinure: ubushakashatsi butandukanye bwagaragaje koHbA1cIgipimo cy’indwara y’umwijima gifitanye isano ryiza n’ubukana bw’ibinure mu mwijima, ndetse n’igihe ibipimo byo gusuzuma diyabete bitagezweho (ibyago byiyongera cyane ukoresheje HbA1c ≥ 5.7%).
• Kugenzura Glycemic ku barwayi b'umwijima urimo ibinure: Abarwayi ba diyabete bafite umwijima urimo ibinure bashobora gukenera gucunga isukari mu maraso mu buryo buhanitse (hafi ya HbA1c) kugira ngo bagabanyirize indwara z'umwijima.

5. Ingamba zo Gukemura Ibibazo: KunozaInsuliniUbuhanga bwo kwiyumvisha ibintu

• Guhindura imibereho: kugabanya ibiro (kugabanya ibiro 5-10% byongera cyane ibinure mu mwijima), indyo nkeya ya karubohidrati/ibinure bike, imyitozo ngororamubiri.
• Imiti:
  • Insulinisimiti itera imbaraga (urugero: metformin, pioglitazone) ishobora kunoza uburyo umwijima n'imisemburo ya glucose bitunganywa.
  • Agontineri za GLP-1 (urugero: liraglutide, semaglutide) zifasha mu kugabanya ibiro, kugenzura glycemic, no kugabanya ibinure mu mwijima.
• Gukurikirana: Kwiyiriza ubusainsuline, HOMA-IR (igipimo cyo kurwanya insuline), HbA1c n'isuzuma ry'umwijima/elastography byapimwe buri gihe.

Umwanzuro

Umwijima urimo ibinure na insuline (cyangwa hyperinsulinemia) bigira uruhererekane rubi binyuze mu kunanirwa kwa insuline. Gutera imbere hakiri kare kwainsulineUbudahangarwa bw'umubiri butuma habaho imikorere y'ibinure mu mwijima no mu isukari, kandi bigabanya ibyago byo kurwara diyabete no kurwara umwijima. Ibipimo bya metabolike bigomba gusuzumwa hamwe mu ivuriro aho kwibanda ku kimenyetso kimwe gusa.

Baysen Medical ihora yibanda ku buryo bwo gusuzuma kugira ngo irusheho kuba nziza. Twakoze ikoranabuhanga rigezweho rigizwe na: Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, OurIkizamini cya HbA1c,Ikizamini cya insulinenaIkizamini cya C-peptide byoroshye gukora kandi ushobora kubona igisubizo cy'ikizamini mu minota 15