Isano iri hagati yumwijima wamavuta na Insuline

Isano iri hagati yumwijima wamavuta na insuline ya Glycated ni isano ya hafi hagati yumwijima wamavuta (cyane cyane indwara yumwijima utarimo inzoga, NAFLD) nainsuline(cyangwainsulinekurwanya, hyperinsulinemia), ihuzwa cyane cyane no guhindagurika kwa metabolike (urugero, umubyibuho ukabije, ubwoko bwa 2diyabete,n'ibindi). Ibikurikira nisesengura rirambuye ryingingo zingenzi:


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1. InsulineKurwanya nkuburyo bwibanze

  • InsulineKurwanya (IR) ni ishingiro rusange ryindwara yumwijima wamavuta na glucose metabolism idasanzwe. Iyo umubiri wiyumvamo insuline ugabanutse, pancreas isohora byinshiinsuline(hyperinsulinemia), bigatuma urugero rwa insuline rwiyongera.
  • Ingaruka z'umwijima w'amavuta: hepatikeinsulineKurwanya birinda aside irike, itera sintezeza ibinure (lipide deposition), kandi byongera ikwirakwizwa ryamavuta muri hepatocytes (steatose).
  • Ishyirahamwe hamweHbA1c: Nubwo insuline ya glycated itari ikimenyetso gikoreshwa cyane mubuvuzi, hyperglycemia igihe kirekire (ifitanye isano na IR) yongera gemoglobine glycated(HbA1c), byerekana isukari nke mu maraso, bifitanye isano no gutera umwijima w'amavuta kuri steatohepatite idafite inzoga (NASH).

2. Hyperinsulinemia itera Indwara Yumwijima

  • Igikorwa kiziguye: Hyperinsulinemia itera hepogenezi ya hepatike (↑ lipid synthesis) binyuze mugukora ibintu byandikirwa (urugero SREBP-1c) mugihe ibuza aside irike β-okiside.
  • Ingaruka itaziguye:InsulineKurwanya bitera tipusi ya adipose kurekura aside irike yubusa (FFAs), yinjira mwumwijima igahinduka triglyceride, bikarushaho kuba bibi umwijima.

3. Umwijima w'amavuta wongera glucose metabolism idasanzwe

  • UmwijimaInsulineKurwanya: Umwijima w'amavuta urekura cytokine ikongora (urugero, TNF-α,IL-6) na adipokine (urugero, kurwanya leptine, kugabanuka kwa adiponectine), kwangirika kwa insuline sisitemu.
  • Kwiyongera kwa glucose ya hepatike:insulineKurwanya bivamo umwijima udashobora guhagarika neza gluconeogenez, kandi kuzamura glucose yamaraso yo kwiyiriza birusheho kwangiza glucose metabolism (gutera imbere kwa diyabete yo mu bwoko bwa 2).

4. Ibimenyetso bya Clinical:Glycosylated Hemoglobin (HbA1c)n'umwijima w'amavuta

  • Hejuru ya HbA1c ihanura ibyago byumwijima byumwijima: ubushakashatsi bwinshi bwerekanye koHbA1curwego rufitanye isano nuburemere bwumwijima bwumwijima, nubwo mugihe ibipimo byo gusuzuma diyabete bitujujwe (ibyago byiyongera cyane hamwe na HbA1c ≥ 5.7%).
  • Igenzura rya Glycemic mu barwayi b'umwijima w'amavuta: Abarwayi ba diyabete bafite umwijima w'amavuta barashobora gusaba gucunga neza isukari mu maraso (intego ya HbA1c yo hasi) kugira ngo indwara z'umwijima zitinde.

5. Ingamba zo Gutabara: GutezimbereInsulineIbyiyumvo

  • Guhindura imibereho: kugabanya ibiro (kugabanuka ibiro 5-10% byongera cyane umwijima wamavuta), karubone-hydrata / indyo yuzuye amavuta, imyitozo yindege.
  • Imiti:
    • Insulinsensitizers (urugero, metformin, pioglitazone) irashobora kunoza umwijima wamavuta hamwe na glucose metabolism.
    • GLP-1 reseptor agonist (urugero, liraglutide, semaglutide) ifasha mukugabanya ibiro, kurwanya glycemic, no kugabanya umwijima w'amavuta.
  • Gukurikirana: Kwiyiriza ubusainsuline, HOMA-IR (indangagaciro yo kurwanya insuline), HbA1c hamwe no kwerekana umwijima / elastografiya.

Umwanzuro

Umwijima w'amavuta kandi insuline (cyangwa hyperinsulinemia) ikora uruziga rukabije binyuze mukurwanya insuline. Kwitabira hakiri kareinsulinekurwanya birwanya umwijima mwinshi hamwe na glucose metabolism kandi bigabanya ibyago bya diyabete na fiboside yumwijima. Ibimenyetso bya metabolike bigomba gusuzumirwa hamwe mu ivuriro aho kwibanda ku kimenyetso kimwe cyonyine.

Twebwe ubuvuzi bwa Baysen buri gihe twibanda kubuhanga bwo gusuzuma kugirango tuzamure ubuzima. Twateje imbere tekinoroji 5 yikoranabuhanga- Latex, zahabu ya colloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, YacuIkizamini cya HbA1c,Ikizamini cya insulinenaIkizamini C-peptide imikorere yoroshye kandi irashobora kubona ibisubizo byikizamini muminota 15

 

 


Igihe cyo kohereza: Jul-09-2025