Ikizamini kitagerwaho:Fecal Calprotectin"Yambuka Imipaka" kugirango afashe Gusuzuma hakiri kare Indwara ya GI yo hejuru mu bana

Mu rwego rwo gusuzuma indwara zifata ibyokurya byabana, endoskopi imaze igihe kinini ari "zahabu" yo kumenya uburibwe bwa gastrointestinal. Nyamara, iri suzuma ryibasiwe ntabwo riherekejwe gusa no kutamererwa neza kubana, cyane cyane abakiri bato, ariko kandi akenshi bizana ubwoba bwimitekerereze ningorabahizi mubufatanye. Ibi bituma ababyeyi benshi batindiganya mugihe cyo kwisuzumisha bwa mbere kandi barashobora kubura amahirwe yo gutabara hakiri kare.Mu minsi ishize, ubushakashatsi bushya bwamavuriro hamwe nuburyo bwo gusaba bwazanye amakuru ashimishije:fecal calprotectin (FCP), ikimenyetso gikuze kitagutera imbaraga zo gusuzuma indwara zo mu gifu cyo hasi, kirerekana imbaraga nyinshi mugupima hakiri kare indwara yo hejuru ya gastrointestinal yanduye ku bana, igera kuri "kwambuka" gutangaje kuva "amara yo hepfo" kugeza "amara yo hejuru".

Kuva kuri Dilemma ya "Zahabu Zahabu" kugeza Umuseke wo Kwipimisha

Indwara ya gastrointestinal yo hejuru nka gastrite na gastroduodenitis ntabwo isanzwe mubana, kandi mubitera harimo kwandura, ibiyobyabwenge, hamwe no guhangayika. Ubusanzwe, kwisuzumisha bisaba kureba neza hamwe na biopsy ya tissue binyuze muri gastroscopi, ibyo bikaba inzira igoye kandi itera. Uburyo budasobanutse kandi bworoshye bwo gutahura burigihe nicyo cyifuzo rusange cyabaganga nimiryango yabana bafite iyo ndwara.Fecal calprotectinni poroteyine yerekana neutrophil. Iyo mucosa gastrointestinal yaka, ubunini bwayo buziyongera cyane. Mu myaka yashize, yagiye ikoreshwa cyane mugusuzuma ibikorwa byindwara zifata amara (IBD) hamwe no gusuzuma itandukaniro rya syndrome de munda (IBS), cyane cyane kubyimba amara.

Ubushakashatsi bwa siyansi bwemeza ishingiro rikomeye rya "kwambuka imipaka"

Umubiri ukura wubushakashatsi werekana ko iki kimenyetso cyo gutwika kitari mu mara gusa. Iyo gutwika gukomeye bibaye mu gice cyo hejuru cya gastrointestinal (nk'igifu na duodenum), selile inflammatory nayo irinjira ikarekuracalprotectin. Iyi poroteyine igenda mu nzira igogora hamwe n'amazi yo mu gifu hamwe n'ibisigazwa by'ibiribwa, amaherezo bikagaragara mu ntebe. Ubushakashatsi buherutse gukorwa mu bana bwerekanye kofecal calprotectinurwego ruri hejuru cyane mubana barwaye gastrite cyangwa duodenitis yemejwe na endoskopi ugereranije nabafite dyspepsia ikora cyangwa ibisubizo bisanzwe bya endoskopique.Nubwo urwego rwa FC rwazamutse rwatewe no gutwika gastrointestinal hejuru muri rusange ruri munsi ugereranije n’urwo muri IBD ikora, bagaragaje itandukaniro rishingiye ku mibare ugereranije n’abantu bafite ubuzima bwiza. Ibi byerekana ko kwipimisha FC bishobora gukoreshwa nkigikoresho cyiza cyo gusuzuma kugirango gifashe abaganga kubanza kumenya abana bafite ibyago byinshi byo kwandura gastrointestinal organique mubana benshi bagaragaza ibimenyetso nkububabare bwo munda, kubyimba, no kugira isesemi.

Agaciro ka Clinical: Kubaka Inzira Nziza Yabana bato

Kwambukiranya imipaka yafecal calprotectinyazanye inyungu nyinshi mugupima no gucunga indwara zo munda zo hejuru mubana:

1.Ntibitera kandi byubahirizwa cyane: Gusa harasabwa urugero ruto rwicyitegererezo cyintebe, kandi inzira ntisanzwe rwose, igabanya cyane umutwaro wumubiri nubwenge kubana. Ababyeyi bemera cyane ubwo buryo, byoroshye gukora byihuse kugenzura kenshi mumavuriro yo hanze.
2.Isuzuma ryiza nigikoresho cya triage: Kubana bafite ibimenyetso bya gastrointestinal idahoraho,Fecal Calprotectinkwipimisha birashobora gukorwa mbere kugirango bitandukane neza n'indwara ziterwa no gukora. NibaFecal calprotectinurwego ni ibisanzwe, ibintu bikora birashobora gushyirwa imbere cyangwa kuvura bifatika no kwitegereza bishobora kwemerwa. Niba urwego rwa FC ruzamutse, rutanga urufatiro rukomeye rwa gastroscopi itera, wirinda inzira ya endoskopi idakenewe no guhitamo itangwa ryubuvuzi.
3.Fecal Calprotectinurwego rushobora kuba nk'ikimenyetso gifatika cyo gusuzuma niba umuriro wagabanutse kandi niba kuvura ari byiza. Irashobora kandi gufasha gutahura indwara hakiri kare.

Ibizaza

Birumvikana ko ikoreshwa rya fecal calprotectin mu gice cyo hejuru cya gastrointestinal iracyasaba ubundi bushakashatsi kugirango hamenyekane neza agaciro kayo ko kugabanuka no kwirinda izindi mpamvu zo munda zishobora gutera FC kuzamuka. Nyamara, nkuburyo bwizewe, bworoshye, kandi buhendutse bwo gusuzuma, nta gushidikanya ko bufungura umuryango mushya wo gusuzuma hakiri kare indwara ya gastrointestinal inflammation ku bana. Irerekana intambwe yatewe mugupima indwara zifata abana zifata inzira yubumuntu kandi busobanutse. Twizera ko hamwe nubushakashatsi bwimbitse hamwe nuburambe bwubuvuzi,fecal calprotectin,iyi “nyenyeri yambukiranya,” izagira uruhare runini mu kurinda ubuzima bwigifu bwabana.

Ubuvuzi bwa Baysen buri gihe bwibanda kubuhanga bwo gusuzuma kugirango ubuzima bwiza bugerweho. Twateje imbere tekinoroji 5 yikoranabuhanga- Latex, zahabu ya colloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Dufite Zahabu ya Colloidal.Fecal calprotectin ibikoresho byo kwipimisha hamwe na Fluorescence ImmunoassayIkizamini cya Calprotectinyo kwipimisha