Ferritin: Biomarker Yihuse kandi Yukuri yo Kugaragaza Ibura rya Iron na Anemia

Intangiriro

Kubura fer hamwe no kubura amaraso ni ibibazo bisanzwe byubuzima ku isi, cyane cyane mubihugu bikiri mu nzira y'amajyambere, abagore batwite, abana n'abagore bafite imyaka yo kubyara. Kubura fer nke (IDA) ntabwo bigira ingaruka kumikorere yumubiri nubwenge gusa, ahubwo birashobora no kongera ibyago byo gutwita no gutinda gukura kwabana. Kubwibyo, gusuzuma hakiri kare no gutabara ni ngombwa. Mu bipimo byinshi byerekana, ferritine yabaye igikoresho cyingenzi cyo gusuzuma ibura rya fer na anemia bitewe nubukangurambaga bukabije kandi bwihariye. Iyi ngingo izaganira ku biranga ibinyabuzima bya ferritine, ibyiza byayo mu gusuzuma ibura rya fer na anemia, n’agaciro kayo kavurwa.

Ibinyabuzima birangaFerritin

Ferritinni poroteyine yo kubika ibyuma igaragara cyane mubice byabantu. Ihinduranya cyane cyane umwijima, impyiko n'amagufa. Igikorwa cyacyo nyamukuru ni ukubika ibyuma no kugenzura uburinganire bwa metabolism. Mu maraso, kwibanda kwaferritinbifitanye isano neza nububiko bwicyuma cyumubiri. Noneho, serumuferritinurwego nimwe mubimenyetso byerekana ibimenyetso byububiko bwumubiri. Mubihe bisanzwe, urugero rwa ferritine kubagabo bakuze ni 30-400 ng / mL, naho kubagore ni 15-150 ng / mL, ariko mugihe habuze fer, agaciro kazagabanuka cyane.

Ibyiza byaFerritinMugusuzuma Ibura rya Iron

1. Kwiyunvikana cyane, gutahura hakiri kare kubura fer

Iterambere ryo kubura fer rigabanijwemo ibyiciro bitatu:

• Icyiciro cyo kubura ibyuma: kubika ibyuma(ferritine) igabanuka, ariko hemoglobine ni ibisanzwe;
• Kubura fer erythropoiesis icyiciro:ferritinbikomeza kugabanuka, kwiyuzuza kwa transrin bigabanuka;
• Icyiciro cyo kubura fer yo kubura fer: hemoglobine iragabanuka, kandi ibimenyetso bisanzwe byo kubura amaraso.

Uburyo bwa gakondo bwo gusuzuma (nko gupima hemoglobine) bushobora gusa kumenya ibibazo murwego rwo kubura amaraso, mugiheferritinkwipimisha birashobora kumenya ibintu bidasanzwe mugihe cyambere cyo kubura fer, bityo bigatanga amahirwe yo gutabara hakiri kare.

2. Umwihariko wo hejuru, Kugabanya Gusuzuma nabi

Indwara nyinshi (nk'umuriro udakira no kwandura) zirashobora gutera amaraso make, ariko ntabwo ziterwa no kubura fer. Muri iki gihe, kwishingikiriza gusa kuri hemoglobine cyangwa bivuze ingano ya corpuscular (MCV) bishobora kutamenya neza impamvu.Ferritinkwipimisha birashobora gutandukanya neza ikibazo cyo kubura fer nubundi bwoko bwa anemia (nka anemia yindwara zidakira), kunoza neza kwisuzumisha.

3. Byihuse kandi byoroshye, bikwiranye no kwipimisha binini

Ikoreshwa rya kijyambere ryibinyabuzima ryibinyabuzima rituma ferritine yiyemeza byihuse kandi byubukungu, kandi irakwiriye mumishinga yubuzima rusange nko gusuzuma abaturage, kwita kubuzima bw’ababyeyi n’abana, no gukurikirana imirire y’abana. Ugereranije n'ibizamini bitera nka bone marrow fer irangi (igipimo cya zahabu), gupima serumu ferritine biroroshye kuzamura.

Amavuriro ya Ferritine mubuyobozi bwa Anemia

1. Kuyobora uburyo bwo kuvura ibyuma

Ferritinurwego rushobora gufasha abaganga kumenya niba abarwayi bakeneye inyongera ya fer no gukurikirana imikorere yubuvuzi. Urugero:

• Ferritin<30 ng / mL: byerekana ko ububiko bwibyuma bwashize kandi hakenewe kongerwamo ibyuma;
• Ferritin<15 ng / mL: byerekana cyane kubura amaraso;
• Iyo kuvura ari byiza, ferritin urwego ruzamuka buhoro buhoro kandi rushobora gukoreshwa mugusuzuma imikorere

1. Kuyobora ibyongeweho ibyuma

Ferritinurwego rufasha abaganga kumenya ibikenewe byo kuvura ibyuma no gukurikirana imikorere yubuvuzi. Urugero:

• Ferritin<30 ng / mL: Yerekana ububiko bwibyuma byashize, bisaba kongerwaho.
• Ferritin<15 ng / mL: Byerekana cyane kubura amaraso make.
• Mugihe cyo kuvura, kuzamukaferritinurwego rwemeza kuvura neza.

2. Kugaragaza abantu badasanzwe

• Abagore batwite: icyifuzo cya fer cyiyongera mugihe utwite, kandiferritinkwipimisha birashobora gukumira ingorane z'ababyeyi n'abana.
• Abana: kubura fer bigira ingaruka kumikurire yubwenge, kandi kwisuzumisha hakiri kare birashobora kunoza imenyekanisha.
• Abarwayi bafite indwara zidakira: nk'abarwayi barwaye impyiko n'indwara y'amara,ferritin ihujwe no kwiyuzuza kwa transfrin irashobora kumenya ubwoko bwa anemia.

Imipaka yaFerritinKwipimisha no gukemura

Nubwo ferritine ari cyo kimenyetso cyerekana ibipimo byo kubura fer, igomba gusobanurwa witonze mu bihe bimwe na bimwe:

• Gutwika cyangwa kwandura:Ferritin, nka poroteyine ikaze ya proteine, irashobora kuzamurwa mubinyoma mu kwandura, kubyimba cyangwa gutwika karande. Muri iki kibazo, irashobora guhuzwa hamweC-reaction proteine (CRP) orkwimurakwiyuzuzamo guca urubanza rwuzuye.
• Indwara y'umwijima:Ferritinku barwayi barwaye cirrhose barashobora kwiyongera kubera kwangirika kwingirangingo zumwijima kandi bigomba gusuzumwa hamwe nibindi bipimo byerekana metabolism.

Umwanzuro

Ferritinkwipimisha byahindutse igikoresho cyingenzi cyo gusuzuma ibura rya fer na anemia bitewe nubukangurambaga bukabije, umwihariko kandi byoroshye. Ntishobora gusa kumenya ibura rya fer hakiri kare kandi ikirinda gutera amaraso make, ariko kandi ikanayobora uburyo bunoze bwo kuvura no kunoza imenyekanisha ry’abarwayi. Mubuzima rusange nubuvuzi rusange, kuzamuraferritin kwipimisha birashobora gufasha kugabanya umutwaro windwara ziterwa no kubura fer, cyane cyane kumatsinda afite ibyago byinshi (nk'abagore batwite, abana n'abarwayi bafite indwara zidakira). Mugihe kizaza, hamwe niterambere ryiterambere rya tekinoroji,ferritin irashobora kugira uruhare runini mukwirinda no kurwanya anemia kwisi yose.

Twebwe ubuvuzi bwa Baysen buri gihe twibanda kubuhanga bwo gusuzuma kugirango tuzamure ubuzima. Twateje imbere tekinoroji 5 yikoranabuhanga- Latex, zahabu ya colloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, YacuIkizamini cya Ferritin imikorere yoroshye kandi irashobora kubona ibisubizo byikizamini muminota 15