C-Reaction Protein (CRP) ni poroteyine ikorwa n'umwijima, kandi urugero rwayo mu maraso ruzamuka cyane bitewe no gutwika. Ivumburwa ryayo mu 1930 hamwe n’ubushakashatsi bwakurikiyeho byashimangiye uruhare rwayo nka kimwe mu bintu byingenzi kandi bikoreshwa cyane mu buvuzi bwa kijyambere. Akamaro ko kwipimisha CRP kari mubikorwa byacyo nkibyiyumvo, nubwo bidasanzwe, byerekana umuriro, bifasha mugupima, gutondeka ibyago, no gukurikirana ibintu byinshi.

1. Ikimenyetso Cyiza cyo Kwandura no Gutwika
Bumwe mu buryo bwibanze bwa CRP ni mukumenya no gucunga indwara, cyane cyane indwara ziterwa na bagiteri. Mugihe izamuka rya CRP nigisubizo rusange mubitwikwa, urwego rushobora kwiyongera cyane mundwara ziterwa na bagiteri, akenshi zirenga 100 mg / L. Ibi bituma biba ingirakamaro mugutandukanya bagiteri na virusi zanduye, kuko mubisanzwe bitera kuzamuka cyane. Mugihe cyamavuriro, CRP ikoreshwa mugupima indwara nka pnewoniya, sepsis, nindwara zimaze kubagwa. Kurugero, gukurikirana urwego CRP nyuma yo kubagwa bifasha abaganga kumenya ingorane nko kwandura ibikomere cyangwa ibisebe byimbitse hakiri kare, bigatuma habaho gutabara vuba. Ifite kandi uruhare runini mu kurwanya indwara zidakira zidakira nka rubagimpande ya rubagimpande n’indwara zifata amara (IBD), aho ibipimo bikurikirana bifasha gupima ibikorwa byindwara ndetse nuburyo bwiza bwo kuvura anti-inflammatory.

2. Isuzuma ry'ingaruka z'umutima n'imitsi: hs-CRP
Iterambere rikomeye murwego ni iterambere ryibizamini bya CRP (hs-CRP). Iki kizamini gipima urwego rwo hasi cyane rwa CRP, mbere bitamenyekanye. Ubushakashatsi bwerekanye ko gutwika indwara zidakira, zo mu rwego rwo hasi mu rukuta rwa arterial ari umushoferi w'ingenzi wa aterosklerose - kubaka icyapa gishobora gutera indwara z'umutima ndetse n'indwara. hs-CRP ikora nka biomarker ikomeye kuriyi mitsi yimitsi.
Ishyirahamwe ry’imitima y'Abanyamerika ryemera ko hs-CRP ari ibintu byigenga by’indwara zifata umutima. Abantu bafite urwego rwa hs-CRP murwego rwo hejuru-rusanzwe (hejuru ya mg / L 3) bafatwa nkaho bafite ibyago byinshi byindwara z'umutima uzaza, kabone niyo urugero rwa cholesterol rusanzwe. Kubera iyo mpamvu, hs-CRP ikoreshwa mugutunganya isuzuma ryibyago, cyane cyane kubarwayi bafite ibyago hagati. Ibi bituma habaho ingamba zihariye zo gukumira, nko gutangiza imiti ya statin kubantu bashobora kutavurwa hashingiwe ku mpamvu gakondo zishobora kubaho.

3. Gukurikirana igisubizo cyo kuvura no guhanura
Usibye gusuzuma no gusuzuma ingaruka, CRP nigikoresho cyiza cyo kugenzura uko umurwayi yitabira kwivuza. Mu ndwara zandura, kugabanuka kwa CRP ni ikimenyetso gikomeye cyerekana ko antibiyotike cyangwa imiti igabanya ubukana ari ingirakamaro. Mu buryo nk'ubwo, mu bihe bya autoimmune, kugabanuka kwa CRP bifitanye isano no guhagarika neza umuriro ukoresheje imiti ikingira indwara. Iyi miterere yingirakamaro ituma abaganga bahindura gahunda yo kuvura mugihe nyacyo. Byongeye kandi, urwego rwo hejuru rwa CRP rukunze kuba rujyanye no guhanura nabi mubihe bitandukanye kuva kanseri kugeza kunanirwa k'umutima, bigatanga idirishya muburemere bwindwara n'inzira.

Imipaka n'Umwanzuro
Nubwo ifite akamaro, imbogamizi ikomeye ya CRP nuburyo budasanzwe. Urwego rwo hejuru rwerekana ko hari umuriro ariko ntugaragaza impamvu yabyo. Guhangayika, ihahamuka, umubyibuho ukabije, hamwe nibihe bidakira birashobora kuzamura CRP. Kubwibyo, ibisubizo byayo bigomba guhora bisobanurwa murwego rwamateka yubuvuzi bwumurwayi, kwisuzumisha kumubiri, nibindi byagaragaye mu gusuzuma.

Mu gusoza, akamaro ko gupima CRP ni byinshi. Kuva gukora nk'ikizamini cyambere cyanduye cyane kugeza igihe cyo guhanura ibintu byigihe kirekire byindwara z'umutima-mitsi binyuze muri hs-CRP, iyi biomarker nigikoresho cyingirakamaro mububiko bwumuganga. Ubushobozi bwabwo bwo gupima no kugenzura ibicanwa byahinduye cyane ubuvuzi bw’abarwayi mu gusuzuma, kuyobora, no gusuzuma ibizagerwaho mu buhanga bwinshi bw’ubuvuzi.