Nhanganyaya: Kukosha kweKliniki kweKutarisa Kwebasa Reitsvo Pakutanga:

Chirwere cheitsvo chisingaperi (CKD) chave dambudziko guru pasi rose rehutano hwevanhu. Zvichienderana nenhamba dzeWorld Health Organization, vanhu vanosvika mamiriyoni 850 pasi rose vanotambura nezvirwere zvakasiyana-siyana zveitsvo, uye kuwanda kwezvirwere zveitsvo zvisingaperi pasi rose kuri pa9.1%. Chinonyanya kuipa ndechekuti chirwere cheitsvo chisingaperi chinowanzova chisina zviratidzo zvakajeka, zvichiita kuti varwere vakawanda vasawane nguva yakanakira yekupindira. Zvichienderana neizvi,microalbuminuria, sechiratidzo chinonzwisisika chekukuvara kweitsvo pakutanga, chave kukosha zvakanyanya. Nzira dzechinyakare dzekuongorora mashandiro eitsvo dzakadai se serum creatinine uye chiyero chekufungidzirwa che glomerular filtration (eGFR) dzinongoratidza kusarongeka kana mashandiro eitsvo akarasika neanopfuura 50%, nepo kuongororwa kwe albumin yeweti kuchigona kupa zviratidzo zvekuyambira kana mashandiro eitsvo akarasika ne10-15%.

Kukosha kwekiriniki uye mamiriro azvino eALBbvunzo yeweti

Albumin (ALB) ndiyo puroteni yakawanda kwazvo muweti yevanhu vane hutano, ine mwero wekubvisa weti uri pasi pe30mg/24a. Kana mwero wekubvisa albumin uri pakati pe30-300mg/24a, inotsanangurwa se microalbuminuria, uye danho iri ndiro nguva yekubudirira yekudzora kukuvara kweitsvo. Parizvino, iyo inowanzoshandiswaALBNzira dzekuongorora chirwere ichi mukiriniki dzinosanganisira radioimmunoassay, enzyme-linked immunosorbent assay (ELISA), immunoturbidimetry, nezvimwewo, asi nzira idzi dzinowanzova nematambudziko akadai sekushanda kwakaoma, kushandiswa kwenguva refu, kana kudiwa kwemidziyo yakakosha. Kunyanya kuzvipatara zvekutanga uye mamiriro ekutarisa kumba, matekinoroji aripo akaoma kusangana nezvinodiwa zvekureruka, kukurumidza, uye kururama, zvichikonzera kuti varwere vakawanda vane kukuvara kweitsvo vasati vawanikwa nenguva.

Kubudirira Kutsva muKunyatsoongororaKuedzwa kweWeti yeALBReagent

Kupindura kudziviswa kwetekinoroji yekuedza iripo, kambani yedu yakagadzira PrecisionKuedzwa kweWeti yeALB Chinogadzirisa zvinhu kuti chibudirire mune zvakawanda zvetekinoroji. Chinogadzirisa zvinhu chinoshandisa tekinoroji yepamusoro ye immunochromatographic ine hukama hwakakura uye antibody yemhando yepamusoro ye anti-human albumin monoclonal kuti ive nechokwadi chekuti bvunzo yacho yakarurama uye yakavimbika. Kuvandudzwa kwehunyanzvi kunonyanya kuratidzwa muzvikamu zvitatu:

• Kunzwa kwacho kwakawedzera zvakanyanya: muganho wakaderera wekuonekwa unosvika 2mg/L, uye unokwanisa kuona nemazvo chiyero che microalbumin che30mg/24h, izvo zviri nani kupfuura kunzwa kwezvishandiso zvekuedza zvechinyakare.
• Kugona kwakawedzerwa kwekudzivirira kukanganiswa: Kuburikidza nekugadzirwa kwesystem ye buffer, inogona kukunda zvinobudirira kukanganiswa kwekuchinja kwe pH yeweti, shanduko yesimba re ionic nezvimwe zvinhu pamhedzisiro yebvunzo, zvichiita kuti bvunzo igare yakasimba pasi pemamiriro akasiyana emuviri.
• Kuona huwandu hutsva: muverengi anotsigira anogona kuona huwandu hushoma kubva pahuwandu kusvika pahuwandu, huwandu hwekuona hunosanganisira 0-200mg/L, kuti asangane nezvinodiwa zvekiriniki zvakasiyana kubva pakuongororwa kusvika pakutariswa.

Kushanda Kwechigadzirwa Uye Zvakanakira

Yakabvumidzwa muzvipatara zvakawanda zvepamusoro, reagent iyi inoratidza zviratidzo zvakanaka zvekushanda. Kana ichienzaniswa nechiyero chegoridhe chealbumin yeurine quantification yemaawa makumi maviri nemana, coefficient yekubatana inosvika kupfuura 0.98; intra- uye inter-batch coefficients of variation iri pasi pe5%, yakaderera zvikuru pane standard yeindasitiri; nguva yekuona imaminitsi gumi nemashanu chete, izvo zvinovandudza zvakanyanya kushanda kwekiriniki. Zvakanakira zvechigadzirwa zvakapfupikiswa pazasi:

• Kushanda zviri nyore: hapana chikonzero chekurapa kwakaoma, weti inogona kuiswa zvakananga pamuenzaniso, kuvhiyiwa kwematanho matatu kuti bvunzo ipedzwe, vasiri nyanzvi vanogona kugona mushure mekudzidziswa kwenguva pfupi.
• Mhedzisiro yekunzwisisa: kushandiswa kwehurongwa hwekugadzira mavara hwakajeka, ziso rakashama rinogona kuverengwa pakutanga, makadhi emavara anoenderana anogona kunge ari ongororo yehuwandu, kuti ienderane nezvinodiwa nemamiriro akasiyana ekushandisa.
• Inodhura uye inoshanda: mutengo webvunzo imwe chete wakaderera zvakanyanya pane webvunzo dzemurabhoritari, dzakakodzera kuongororwa kwakakura uye kutariswa kwenguva refu, uye dzine kukosha kukuru pahutano.

• Kukosha kwekutanga kweyambiro: kukuvara kweitsvo kunogona kuonekwa makore 3-5 zvisati zvaitika pane zviratidzo zvekushanda kweitsvo, zvichipa nguva yakakosha yekupindira muchipatara.

Maitiro ekushandisa mukiriniki uye mazano ekutungamira

KunyatsojekaKuongorora Weti yeAlbtine nzira dzakasiyana-siyana dzekushandisa. Munyaya yechirwere cheshuga, gwara reAmerican Diabetes Association (ADA) rinokurudzira zvakajeka kuti varwere vese vane chirwere cheshuga cherudzi rwekutanga vane makore ≥ mashanu uye varwere vese vane chirwere cheshuga cherudzi rwechipiri vanofanira kuongororwa weti albumin gore rega rega. Mukutarisira BP, gwara reESC/ESH rinoratidza microalbuminuria sechiratidzo chakakosha chekukuvara kwenhengo. Pamusoro pezvo, reagent yakakodzera kune dzakawanda mamiriro akadai sekuongororwa kwengozi yezvirwere zvemwoyo, kuongororwa kwebasa reitsvo kune vakwegura, uye kuongororwa kweitsvo panguva yekuzvitakura.

Chinonyanya kufadza ndechekuti chigadzirwa ichi chinonyatsoenderana nezvinodiwa pakuongorora nekurapa kwehurongwa. Chinogona kushandiswa sechishandiso chinoshanda chekuongorora chirwere cheitsvo muzvipatara zvekurapa zvekutanga zvakaita sezvipatara zvemunharaunda nenzvimbo dzehutano dzemumaguta; mumadhipatimendi enephrology ne endocrinology ezvipatara zveruzhinji, chinogona kushandiswa sechishandiso chakakosha chekutarisira chirwere uye kutarisa kushanda zvakanaka; munzvimbo dzekuongorora zvekurapa, chinogona kuiswa mumapakeji ekuongorora hutano kuti chiwedzere huwandu hwekuona kukuvara kweitsvo nekukurumidza; uye chinotarisirwa kutopinda mumusika wekutarisa hutano hwemhuri mushure mekusimbiswa zvakare mune ramangwana.

Mhedziso

Isu Baysen Medical tinogara tichitarisa pakuongorora kuti tivandudze hupenyu. Takagadzira mapuratifomu mashanu etekinoroji - Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. TineBvunzo reALB FIA yekutarisa kukuvara kweitsvo pakutanga