Nhanganyaya: Kukosha Kwekiriniki Yekutanga Renal Basa Kutariswa:

Chirwere cheitsvo chisingaperi (CKD) chave dambudziko rehutano hweveruzhinji pasi rose. Maererano nenhamba dzeWorld Health Organisation, vanhu vangangosvika mamirioni mazana masere nemakumi mashanu pasi rose vanotambura nezvirwere zvakasiyana-siyana zveitsvo, uye kuwanda kwepasi rose kwechirwere cheitsvo chisingaperi kunosvika 9.1%. Chinonyanya kuoma ndechokuti chirwere chekare chekare chisingagumi kazhinji hachina zviratidzo zvakajeka, zvichiita kuti nhamba huru yevarwere vashaye nguva yakanakisisa yekupindira. Pamusana peizvi,microalbuminuria, sechiratidzo chakajeka chekukuvara kweitsvo dzekutanga, yakawedzera kukosha. Nzira dzechinyakare dzekuedza renal basa senge serum creatinine uye inofungidzirwa kuti glomerular filtration rate (eGFR) inongoratidza kusarongeka kana kushanda kwetsvo kwarasika neinopfuura 50%, nepo weti albumin yekuongorora inogona kupa masaini ekutanga ekunyevera kana kushanda kwetsvo kwarasika ne10-15%.

Clinical kukosha uye ikozvino mamiriro eALBweti test

Albumin (ALB) ndiyo mapuroteni akawandisa muweti yevanhu vane hutano, ine yakajairika excretion rate isingasviki 30mg/24h. Kana iyo urinary albumin excretion rate iri mukati meiyo 30-300mg/24h, inotsanangurwa se microalbuminuria, uye iyi nhanho ndiyo yegoridhe nguva yehwindo yekupindira kudzoreredza kukuvara kweitsvo. Parizvino, iyo inonyanya kushandiswaALBnzira dzekuona mukuita kwekiriniki dzinosanganisira radioimmunoassay, enzyme-yakabatana immunosorbent assay (ELISA), immunoturbidimetry, nezvimwewo, asi nzira idzi dzinowanzova nezvinetso zvakaita sekushanda kwakaoma, kushandiswa kwenguva refu, kana kudiwa kwemidziyo yakakosha. Kunyanya kumasangano ekurapa ekutanga uye mamiriro ekutarisa kumba, matekinoroji aripo akaoma kuzadzisa zvinodiwa zvekureruka, kukurumidza, uye kurongeka, zvichikonzera huwandu hukuru hwevarwere vane kukuvara kweitsvo yekutanga kusawanikwa nenguva.

Mabhindauko matsva muPrecisionALB Urine TestReagent

Mukupindura zvisingakwanisi tekinoroji iripo yekuyedza, kambani yedu yakagadzira iyo PrecisionALB Urine Test Reagent kuona akati wandei tekinoroji kubudirira. Iyo reagent inotora advanced immunochromatographic tekinoroji ine hukama hwepamusoro uye yakanyanya kujeka anti-human albumin monoclonal antibody kuti ive nechokwadi chechokwadi uye kuvimbika kwebvunzo. Iyo tekinoroji innovation inonyanya kuratidzwa muzvikamu zvitatu:

• Kunyanya kuvandudzwa kwekunzwa: iyo yakaderera muganhu wekuonekwa inosvika 2mg / L, uye inokwanisa kunyatsoona urinary chikumbaridzo che microalbumin ye 30mg / 24h, iyo iri nani kupfuura kunzwisiswa kwemaitiro echinyakare ekuedza mitsetse.
• Yakavandudzwa anti-kupindira kugona: Kuburikidza neyakasiyana buffer system dhizaini, inogona kukunda zvinobudirira kukanganiswa kweweti pH shanduko, ionic simba shanduko uye zvimwe zvinhu pamhedzisiro yebvunzo, kuve nechokwadi kugadzikana kwebvunzo pasi pemamiriro akasiyana emuviri.
• Innovative quantitative yekuona: muverengi anotsigira akakosha anogona kuona semi-quantitative kusvika kuhuwandu hwekuonekwa, iyo yekuona mhando inovhara 0-200mg/L, kusangana nezvinodiwa zvekiriniki zvakasiyana kubva pakuongorora kusvika pakutarisisa.

Kushanda Kwechigadzirwa uye Zvakanakira

Clinically yakasimbiswa muzvipatara zvepamusoro-soro, iyi reagent inoratidza zviratidzo zvekushanda zvakanaka. Kuenzaniswa neyegoridhe yakajairwa 24-awa weti albumin quantification, iyo corelation coefficient inosvika kupfuura 0.98; intra- uye inter-batch coefficients yekusiyana ishoma pane 5%, yakaderera zvakanyanya pane indasitiri chiyero; nguva yekuona ndeye 15 maminetsi chete, iyo inovandudza zvakanyanya kushanda kwekiriniki. Zvakanakira chigadzirwa zvinopfupikiswa pazasi:

• Kureruka kwekushanda: hapana chikonzero chekuoma kwekutanga kurapwa, weti samples inogona kuve yakananga pamuenzaniso, matatu-nhanho oparesheni yekupedzisa bvunzo, vasiri nyanzvi vanogona kugona mushure mekudzidziswa kwenguva pfupi.
• Intuitive mhedzisiro: kushandiswa kwemavara akajeka ekuvandudza sisitimu, ziso rakashama rinogona kuverengerwa pakutanga, kuenzanisa makadhi emavara anogona kuve semi-quantitative kuongororwa, kusangana nezvinodiwa zveakasiyana mashandisirwo mamiriro.
• Upfumi uye hunoshanda: mutengo webvunzo imwe chete wakadzikira zvakanyanya kupfuura iwo webvunzo dzemurabhoritari, uyo wakakodzera kuongororwa kwakakura uye kutarisa kwenguva refu, uye ine hutano hwakanyanya kukosha kwehupfumi.

• Kukosha kwekutanga yambiro: kukuvara kweitsvo kunogona kuonekwa makore 3-5 zvisati zvaitika pane zviratidzo zvechinyakare renal basa, kuhwina nguva yakakosha yekupindira kwekiriniki.

Clinical application scenarios uye mazano ekukurudzira

PrecisionALB Urine Testine zvakawanda zvakasiyana-siyana zvekushandisa. Mundima yechirwere cheshuga mellitus, nhungamiro yeAmerican Diabetes Association (ADA) inokurudzira zvakajeka kuti varwere vese vane Type 1 chirwere cheshuga mellitus ≥ makore mashanu uye varwere vese vane Type 2 chirwere cheshuga mellitus vanofanirwa kuongororwa weti albumin gore rega. Mukutonga kwehypertension, iyo ESC/ESH hypertension dhairekitori inonyora microalbuminuria sechiratidzo chakakosha chekukuvadzwa kwenhengo inonangwa. Mukuwedzera, iyo reagent inokodzera akawanda mamiriro akadai seyemwoyo chirwere chekuongorora njodzi, renal basa rekuongorora kune vakwegura, uye renal kutarisa panguva yekuzvitakura.

Chinonyanya kufarira ndechekuti chigadzirwa ichi chinonyatsoenderana nezvinodiwa zvehierarchical kuongororwa uye kurapwa. Inogona kushandiswa sechinhu chinoshanda chekuongorora chirwere cheitsvo mumasangano ekurapa ekutanga sezvipatara zvenharaunda uye nzvimbo dzehutano dzekutaundi; mune nephrology uye endocrinology madhipatimendi ezvipatara zvakajairwa, inogona kushandiswa sechinhu chakakosha chekugadzirisa chirwere uye efficacy monitoring; munzvimbo dzekurapa dzekuongorora, inogona kuiswa mumapaketi ekuongorora hutano kuti iwedzere chiyero chekuonekwa kwekukuvara kweitsvo yekutanga; uye zvinototarisirwa kupinda mumusika wekutarisa hutano hwemhuri mushure mekuwedzera kusimbiswa mune ramangwana.

Mhedziso

Isu Baysen Medical inogara yakatarisa nzira yekuongorora yekuvandudza hupenyu. Takagadzira mapuratifomu mashanu ehunyanzvi- Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular,Chemiluminescence Immunoassay.TineALB FIA Muedzo Yekutarisa kukuvara kweitsvo kwekutanga