Chikungunya Virus (CHIKV) Overview

Chikungunya virus (CHIKV) chirwere chinotakurwa neumhutu chinokonzeresa Chikungunya fever. Inotevera ipfupiso yakadzama yehutachiona:

1. Virus Hunhu

• Classification: NdeyeTogaviridaemhuri, genusAlphavirus.
• Genome: Single-stranded positive-strand RNA virus.
• Nzira dzekutapurira: Kunyanya kuparadzirwa neAedes aegypti uye Aedes albopictus, mavector akafanana se dengue uye Zika viruses.

• Endemic nzvimbo: Nzvimbo dzinopisa uye dzinopisa muAfrica, Asia, America, uye Indian Ocean Islands.

2. Clinical performance

• Incubation Period: Kazhinji 3-7 mazuva.
• Zviratidzo Zvakajairika:
  • Kamwe kamwe kupisa kwakanyanya (>39 ° C).
  • Kurwadza kwakanyanya kwemajoini (kunyanya kukanganisa maoko, mawoko, mabvi, nezvimwewo), izvo zvinogona kugara kwemavhiki kusvika kumwedzi.
  • Maculopapular rash (kazhinji pahunde nemakumbo).
  • Kurwadziwa kwetsandanyama, musoro, kudambuka tec.
• Zvisingaperi zviratidzo: Inenge 30% -40% yevarwere vanonzwa marwadzo anoramba aripo, ayo anogona kugara kwemwedzi kana kunyange makore.
• Ngozi yechirwere chakakomba: Vacheche, vakwegura uye varwere vane zvirwere zvisingaperi vanogona kutanga zvinetso zvetsinga (zvakadai semeningitis) kana kufa, asi huwandu hwehuwandu hwekufa hushoma (<1%).

3. Kuongororwa uye kurapwa

• Diagnostic Nzira:
  • Serological bvunzo: IgM/IgG masoja ekudzivirira chirwere (anoonekwa anenge mazuva mashanu mushure mekutanga).
  • Molecular test: RT-PCR (kuonekwa kwehutachiona RNA muchikamu chepamusoro).
  • Kuda kusiyanisa kubvadengue fever, Zika virus, nezvimwewo (zviratidzo zvakafanana)
• Kurapa:
  • Iko hakuna chaiyo antiviral mushonga, uye symptomatic tsigiro ndiyo yakanyanya kurapwa:
    • Kurwadziswa / fivha (kudzivisa aspirin nekuda kwekubuda ropa).
    • Hydration uye kuzorora.
    • Kurwadza kwemajoini kwenguva refu kungada anti-inflammatory drugs kana physiotherapy.

4. Matanho ekudzivirira

• Kudzora Mosquito:
  • Shandisa mambure ekudzivirira umhutu uye zvinodzinga umhutu (kusanganisira DEET, picaridin, nezvimwewo).
  • Bvisa mvura isingayerere (deredza nzvimbo dzinoberekera mosquito).
• Zano rekufamba: Tora chenjedzo paunenge uchienda kunzvimbo dzine hutachiona uye pfeka zvipfeko zvine maoko marefu.
• Kuvandudzwa kwejekiseni: Kubva muna 2023, hapana mishonga yekudzivirira yekutengeserana yakatangwa, asi mamwe majekiseni ekudzivirira ari mumiedzo yekiriniki (senge hutachiona-senge particle vaccines).

5. Hutano Hwevanhu Hunokosha

• Ngozi yekubuda: Nekuda kwekupararira kwakawanda kweumhutu hweAedes uye kudziya kwemamiriro ekunze, huwandu hwekutapurirana hunogona kuwedzera.
• Denda repasi rose: Mumakore achangopfuura, kuputika kwakaitika munzvimbo dzakawanda muCaribbean, South Asia (seIndia nePakistan) neAfrica.

6. Misiyano Yakakosha kubvaDengueKupindwa nechando

• Kufanana: Zvose zvinoparadzirwa neAedes mosquito uye zvine zviratidzo zvakafanana (fivha, rash).
• Kusiyanisa: Chikungunya inoratidzwa nekurwadziwa kwakanyanya kwemajoini, nepodengueinonyanya kukonzera kubuda ropa kana kuvhunduka.

Mhedziso:

Isu Baysen Medical inogara yakatarisa nzira yekuongorora yekuvandudza hupenyu. Takagadzira mapuratifomu mashanu etekinoroji- Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular,Chemiluminescence Immunoassay.Tinotarisawo pakuongororwa zvirwere zvinotapukira,TineDengue NSI kukurumidza kuyedza,Dengue IgG/IgM yekukurumidza bvunzo, Dengue NSI uye IgG/IgM combo kukurumidza bvunzo