Sangano Pakati peGut Inflammation, Kuchembera, uye Alzheimer's Disease Pathology

Mumakore achangopfuura, hukama pakati pegut microbiota uye chirwere chetsinga chave hotspot yekutsvaga. Humbowo hwakawanda hunoratidza kuti kuzvimba kwemukati (sekudonha kweura uye dysbiosis) kunogona kukanganisa kufambira mberi kwezvirwere zveurourodegenerative, kunyanya chirwere cheAlzheimer's (AD), kuburikidza ne "gut-brain axis". Ichi chinyorwa chinoongorora kuti kuzvimba kwematumbo kunowedzera sei nezera uye inotsvaga kushamwaridzana kwayo neAD pathology (yakadai se β-amyloid deposition uye neuroinflammation), ichipa mazano matsva ekutanga kupindira kweAD.

1. Nhanganyaya

Chirwere cheAlzheimer (AD) ndicho chinonyanyozivikanwa neurodegenerative disorder, chinoratidzwa ne β-amyloid (Aβ) plaques uye hyperphosphorylated tau protein. Kunyangwe genetic factor (semuenzaniso, APOE4) ari makuru eAD njodzi zvinhu, pesvedzero yezvakatipoteredza (semuenzaniso, chikafu, hutano hwematumbu) inogonawo kubatsira mukufambira mberi kweAD kuburikidza nekuzvimba kusingaperi. Ura, senhengo huru yemuviri inodzivirira zvirwere, inogona kukanganisa hutano hwehuropi kuburikidza nenzira dzakawanda, kunyanya panguva yekukwegura.

2. Gut Kuzvimba uye Kuchembera

2.1 Kuderera kwakabatana nezera mumatumbo ekudzivirira basa
Nezera, kutendeseka kwechivharo chemukati kunoderera, kunotungamirira ku "leaky gut", zvichiita kuti bhakitiriya metabolites (yakadai se lipopolysaccharide, LPS) ipinde muropa, zvichiita kuti systemic yakaderera-giredhi kuzvimba. Zvidzidzo zvakaratidza kuti kusiyana kwemaruva emukumbo kune vakwegura kunoderera, mabhakitiriya e-pro-inflammatory (akadai seProteobacteria) anowedzera, uye mabhakitiriya anorwisa-kupisa (akadai seBifidobacterium) anoderera, zvichiwedzera kuwedzera mhinduro yekuputika.

2.2 Zvinhu zvinopisa uye kuchembera
Kusagadzikana kwepasi-giredhi kuzvimba ("kuzvimba kuchembera", Inflammaging) chinhu chakakosha chekuchembera. Intestinal kuzvimba zvinhu (sengeIL-6, TNF-α) inogona kupinda muuropi kuburikidza nekutenderera kweropa, activate microglia, kusimudzira neuroinflammation, uye kukurumidza kugadzirisa maitiro eAD.

uye kukurudzira neuroinflammation, nekudaro ichimhanyisa AD pathology.

3. The Link Between Gut Inflammation uye Alzheimer's Disease Pathology

3.1 Gut Dysbiosis uye Aβ Deposition

Mhuka mhando dzakaratidza kuti intestinal flora mhirizhonga inogona kuwedzera Aβ deposition. Semuenzaniso, mbeva dzakarapwa nemishonga yakaderedza Aβ plaques, nepo Aβ mazinga akawedzerwa mumakonzo ane dysbiosis. Mamwe mabhakitiriya metabolites (akadai sepfupi-chain mafuta acids, SCFAs) anogona kukanganisa kubvumidzwa kweAβ nekudzora microglial basa.

3.2 Iyo Gut-Brain Axis uye Neuroinflammation

Gut kuzvimba kunogona kukanganisa huropi kuburikidza nevagal, immune system, uye metabolic nzira:

• Vagal nzira: zviratidzo zvemukati zvekuzvimba zvinotapurirwa kuburikidza neiyo vagus nerve kune CNS, inokanganisa hippocampal uye prefrontal cortex basa.
• Kuzvimba kweSystem: Zvikamu zvehutachiona zvakaita seLPS zvinomisa microglia uye zvinosimudzira neuroinflammation, kuwedzera tau pathology uye neuronal kukuvara.
• Metabolic effects: gut dysbiosis inogona kukanganisa tryptophan metabolism, zvichiita kuti kusaenzana mumaurotransmitters (eg, 5-HT) uye kukanganisa basa rekuziva.

3.3 Clinical Evidence

• Varwere vane AD vane chimiro chakasiyana kwazvo chemaruva emudumbu kupfuura vanhu vakuru vane hutano, semuenzaniso, chiyero chisina kujairika cheThick-walled phylum/Antibacterial phylum.
• Ropa mazinga eLPS anonyatsoenderana nekuoma kweAD.
• Probiotic kupindira (semuenzaniso Bifidobacterium bifidum) inoderedza Aβ deposition uye inovandudza kugona kwekuziva mumhando dzemhuka.

4. Mazano Anogona Kupindira

Kugadziriswa kwekudya: yakakwira-fiber, kudya kweMediterranean kunogona kukurudzira kukura kwebhakitiriya inobatsira uye kuderedza kuzvimba.

1. Probiotics / Prebiotics: kuwedzeredza nemhando dzakasiyana dzebhakitiriya (semuenzaniso, Lactobacillus, Bifidobacterium) inogona kuvandudza gut barrier function.
2. Mishonga inorwisa-kuzvimba: mishonga inonangana nekuzvimba kwemukati (semuenzaniso, TLR4 inhibitors) inogona kunonoka kufambira mberi kweAD.
3. Mararamiro ekupindira: kurovedza muviri uye kuderedza kushushikana kunogona kuchengetedza gut flora chiyero

5. Mhedziso uye Maonero Anouya

Kuzvimba kweGut kunowedzera nezera uye kunogona kubatsira kuAD pathology kuburikidza negut-brain axis. Zvidzidzo zvenguva yemberi zvinofanirwa kujekesa hukama hwekukonzeresa pakati pemaruva chaiwo neAD uye kuongorora kudzivirira kweAD uye nzira dzekurapa zvinoenderana nemutemo weflora. Tsvagiridzo munzvimbo ino inogona kupa zvinangwa zvitsva zvekupindira kwekutanga muzvirwere zveurourodegenerative.

Xiamen Baysen Medical We Baysen Medical inogara yakatarisa nzira yekuongorora yekuvandudza hupenyu hwehupenyu. Takagadzira mapuratifomu mashanu etekinoroji- Latex, colloidal goridhe, Fluorescence Immunochromatographic Assay, Molecular,Chemiluminescence Immunoassay. Isu tinotarisa kune hutano hwematumbo, uye yeduCAL bvunzo inoshandiswa kuona kuzvimba muura.

References :

1. Vogt, NM, nevamwe. (2017). "Gut microbiome shanduko muchirwere cheAlzheimer."Scientific Reports.
2. Dodiya, HB, nevamwe. (2020). "Kuzvimba kwematumbo kunowedzera tau pathology mumhando yegonzo yechirwere cheAlzheimer."Nature Neuroscience.
3. Franceschi, C., nevamwe. (2018). "Kuzvimba: maonero matsva ekudzivirira muviri-metabolism yezvirwere zvine hukama nezera."Nature Ongororo Endocrinology.