Kubatana Pakati Pekuzvimba Kwemudumbu, Kukwegura, uye Pathology yeAlzheimer's Disease

Mumakore achangopfuura, hukama huripo pakati pezvirwere zvemudumbu nezvirwere zvetsinga hwave chinhu chinonyanya kufarirwa pakutsvagisa. Humbowo hwakawanda hunoratidza kuti kuzvimba kwemudumbu (senge kubuda kwemudumbu uye dysbiosis) kunogona kukanganisa kufambira mberi kwezvirwere zvinokanganisa tsinga, kunyanya chirwere cheAlzheimer's (AD), kuburikidza ne "gut-brain axis". Chinyorwa chino chinoongorora kuti kuzvimba kwemudumbu kunowedzera sei nekukura uye chinoongorora hukama hwacho nechirwere cheAD (senge β-amyloid deposition uye neuroinflammation), zvichipa mazano matsva ekupindira kwekutanga kweAD.

1. Nhanganyaya

Chirwere cheAlzheimer (AD) ndicho chirwere chinowanzo shandiswa mukurapa tsinga dzeuropi, chinoratidzwa ne β-amyloid (Aβ) plaques uye hyperphosphorylated tau protein. Kunyangwe zvinhu zvemajini (semuenzaniso, APOE4) zviri zvinhu zvikuru zvinokonzera njodzi yeAD, zvinokanganisa nharaunda (semuenzaniso, kudya, hutano hwematumbu) zvinogonawo kubatsira mukufambira mberi kweAD kuburikidza nekuzvimba kwenguva refu. Utumbo, senhengo huru yemuviri inodzivirira zvirwere, hunogona kukanganisa hutano hwehuropi kuburikidza nenzira dzakasiyana-siyana, kunyanya panguva yekukwegura.

2. Kuzvimba Kwematumbu Uye Kukwegura

2.1 Kuderera kwebasa rekudzivirira ura nekuda kwezera
Nekukura, kusimba kwemudumbu kunoderera, zvichikonzera "kubuda kwemvura mudumbu", zvichibvumira mabhakitiriya (akadai se lipopolysaccharide, LPS) kupinda muropa, zvichikonzera kuzvimba kwemuviri. Zvidzidzo zvakaratidza kuti kusiyana kwezvirimwa zvemudumbu muvanhu vakwegura kunoderera, mabhakitiriya anokonzera kuzvimba (akadai seProteobacteria) anowedzera, uye mabhakitiriya anodzivirira kuzvimba (akadai seBifidobacterium) anoderera, zvichiwedzera kuzvimba.

2.2 Zvinhu zvinokonzera kuzvimba uye kukwegura
Kuzvimba kwenguva refu (“kukwegura kwekuzvimba”, Kuzvimba) chinhu chakakosha pakukwegura. Zvinhu zvinozvimba mudumbu (zvakaita seIL-6, TNF-α) inogona kupinda muuropi kuburikidza nekutenderera kweropa, kumutsa microglia, kukurudzira kuzvimba kweuropi, uye kukurumidzisa maitiro echirwere cheAD.

uye kukurudzira kuzvimba kwetsinga dzeuropi, nokudaro zvichikurumidzisa chirwere cheAD.

3. Kubatana Pakati Pekuzvimba Mudumbu Nechirwere cheAlzheimer's

3.1 Kusashanda zvakanaka kweMatumbu uye Kubviswa kweAβ

Mhando dzemhuka dzakaratidza kuti kukanganiswa kwemaruva emudumbu kunogona kuwedzera kuiswa kweAβ. Semuenzaniso, mbeva dzakarapwa nemishonga inorwisa mabhakitiriya dzakaderedza maAβ plaques, nepo huwandu hweAβ huchiwedzera mumakonzo ane dysbiosis. Mamwe mabhakitiriya (akadai se short-chain fatty acids, SCFAs) anogona kukanganisa kubviswa kweAβ nekudzora mashandiro e microglial.

3.2 Kubatana kweUropi neMatumbu uye Kuzvimba kweNeuro

Kuzvimba kwemudumbu kunogona kukanganisa uropi kuburikidza nenhengo dzemuviri, masoja emuviri, uye nzira dzekugadzirisa muviri:

• Nzira yemudumbu: zviratidzo zvekuzvimba kwemudumbu zvinotumirwa kuCNS kuburikidza netsinga yemudumbu, zvichikanganisa mashandiro ehippocampal neprefrontal cortex.
• Kuzvimba kwemuviri: Zvinhu zvinoumba mabhakitiriya zvakaita seLPS zvinomutsa microglia uye zvinokurudzira kuzvimba kweuropi, zvichiwedzera pathology yetau uye kukuvara kwetsinga dzeuropi.
• Migumisiro yemetabolism: dysbiosis yemudumbu inogona kukanganisa metabolism yetryptophan, zvichikonzera kusawirirana muma neurotransmitters (semuenzaniso, 5-HT) uye kukanganisa mashandiro epfungwa.

3.3 Humbowo hwekiriniki

• Varwere vane AD vane maumbirwo akasiyana zvakanyanya ezvirimwa zvemudumbu nevakuru vane hutano, semuenzaniso, chiyero chisina kujairika cheThick-walled phylum/Antibacterial phylum.
• Kuwanda kweLPS muropa kunoenderana zvakanaka nekuomarara kweAD.
• Kupindira kweprobiotic (semuenzaniso Bifidobacterium bifidum) kunoderedza kuiswa kweAβ uye kunovandudza mashandiro ekuziva mumhuka.

4. Maitiro Ekubatsira Anogona Kuitwa

Kugadziriswa kwezvekudya: kudya kweMediterranean kune fiber yakawanda kunogona kukurudzira kukura kwebhakitiriya inobatsira uye kuderedza kuzvimba.

1. MaProbiotics/Prebiotics: kuwedzerwa kwemhando dzakasiyana dzebhakitiriya (semuenzaniso, Lactobacillus, Bifidobacterium) kunogona kuvandudza mashandiro ekudzivirira ura.
2. Mishonga inoderedza kuzvimba: mishonga inorwisa kuzvimba kwemudumbu (semuenzaniso, TLR4 inhibitors) inogona kunonotsa kufambira mberi kweAD.
3. Kupindira mumararamiro: kurovedza muviri nekuderedza kushushikana zvinogona kuchengetedza hutano hwezvirimwa zvemudumbu

5. Mhedziso neMaonero Eramangwana

Kuzvimba kwemudumbu kunowedzera nekukura uye kunogona kukonzera chirwere cheAD kuburikidza negut-brain axis. Zvidzidzo zveramangwana zvinofanira kujekesa hukama huripo pakati pemiti chaiyo neAD uye kuongorora nzira dzekudzivirira nekurapa AD zvichibva pamitemo yemiti yemudumbu. Tsvakurudzo munzvimbo iyi inogona kupa zvinangwa zvitsva zvekupindira nekukurumidza muzvirwere zvinokanganisa tsinga.

Xiamen Baysen Medical Isu Baysen Medical tinogara tichitarisa pakuongorora hutano hwemuviri kuti tivandudze hupenyu hwemunhu. Takagadzira mapuratifomu mashanu etekinoroji - Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Tinotarisa hutano hwemudumbu, uye hutano hwedu hwemuviri.Bvunzo reCAL inoshandiswa kuona kuzvimba mudumbu.

Mareferensi:

1. Vogt, NM, et al. (2017). "Kuchinja kwe microbiome yemudumbu muchirwere cheAlzheimer."Mishumo yeSainzi.
2. Dodiya, HB, nevamwe. (2020). "Kuzvimba kwematumbu kwenguva refu kunowedzera dambudziko retau mumhando yegonzo yechirwere cheAlzheimer."Sainzi yeUroyo.
3. Franceschi, C., et al. (2018). "Kuzvimba: maonero matsva ekudzivirira muviri nekuchinja kwemuviri kwezvirwere zvine chekuita nekukwegura."Ongororo dzeZvisikwa Endocrinology.