Hukama Huripo Pakati Pechiropa Chine Mafuta uye Insulin

Hukama Huripo Pakati Pechiropa Chine Mafuta neGlycated Insulin hukama hwakasimba pakati pechiropa chine mafuta (kunyanya chirwere chechiropa chine mafuta chisina doro, NAFLD) uyeinsulin(kanainsulinkuramba, hyperinsulinemia), izvo zvinonyanya kukonzerwa nezvirwere zve metabolic (semuenzaniso, kufuta, rudzi rwechipirichirwere cheshuga,nezvimwewo). Izvi zvinotevera ongororo yakadzama yepfungwa huru:

1. InsulinKuramba seMuchina Mukuru

• InsulinKuramba (IR) ndiyo hwaro hunowanzo konzera mafuta muchiropa uye kushanduka kweglucose muropa zvisina kujairika. Kana kunzwa kwemuviri ku insulin kwaderera, pancreas inoburitsa zvakawanda.insulin(hyperinsulinemia), zvichikonzera kuwedzera kwemazinga e insulin muropa.
• Migumisiro yechiropa chine mafuta: chiropainsulinKudzivirira kunodzivirira oxidation yemafuta acid, kunokurudzira kugadzirwa kwemafuta (kuiswa kwemafuta mumuviri), uye kunowedzera kuunganidzwa kwemafuta muhepatocytes (steatosis).
• Kubatana naHbA1cKunyange hazvo insulin ine glycated isiri chiratidzo chinowanzo shandiswa pakurapa, hyperglycemia inoenderera mberi (yakabatana neIR) inowedzera hemoglobin ine glycated(HbA1c), zvichiratidza kusadzora shuga muropa, izvo zvine chekuita nekufambira mberi kwechiropa chine mafuta kusvika pakuva steatohepatitis isina doro (NASH).

2. Hyperinsulinemia Inokurudzira Zvirwere zveChiropa Chine Mafuta

• Kushanda zvakananga: Hyperinsulinemia inokurudzira lipogenesis muchiropa (↑ lipid synthesis) kuburikidza nekushanda kwezvinhu zvinonyora (semuenzaniso SREBP-1c) ukuwo ichidzivisa fatty acid β-oxidation.
• Mhedzisiro Isina Kunanga:InsulinKusasimba kwemafuta kunoita kuti mafuta aburitse mafuta akawanda asina kubhadharwa (FFAs), ayo anopinda muchiropa ochishandurwa kuita triglycerides, zvichiwedzera kuipa kwechiropa chine mafuta.

3. Chiropa Chine Mafuta Chinowedzera Kushandiswa kweglucose muropa

• Zvinokonzereswa neChiropaInsulinKuramba: Chiropa chine mafuta chinoburitsa ma cytokines anokonzera kuzvimba (semuenzaniso, TNF-α,IL-6) uye maadipokines (semuenzaniso, kuramba leptin, kudzikira kweadiponectin), zvichiwedzera kuramba insulin mumuviri.
• Kuwedzera kweglucose muropa:insulinKusakwanisa kuita zvinhu zvinovaka muviri kunoita kuti chiropa chisakwanise kudzivirira gluconeogenesis, uye kuwedzera kweshuga muropa risingadyi zvekudya kunowedzera kuipa kwemetabolism yeshuga (zvinogona kuitika kuti munhu apindwe mushuga werudzi rwechipiri).

4. Humbowo hwekiriniki:Hemoglobin yeGlycosylated (HbA1c)uye Chiropa Chine Mafuta

• HbA1c yakakwira inofanotaura njodzi yechiropa chine mafuta: zvidzidzo zvakati wandei zvakaratidza kutiHbA1cMazinga acho anoenderana zvakanaka nekuoma kwechiropa chine mafuta, kunyangwe kana zvinodiwa pakuongororwa kwechirwere cheshuga zvikasazadzikiswa (njodzi inowedzera zvakanyanya neHbA1c ≥ 5.7%).
• Kudzora Glycemic muVarwere vane Chiropa Chine Mafuta: Varwere vane chirwere cheshuga vane chiropa chine mafuta vangada kutarisirwa kwakasimba kweshuga muropa (zvinotarisirwa pasi peHbA1c) kuti vaderedze kufambira mberi kwechirwere chechiropa.

5. Maitiro Ekubatsira: KuvandudzaInsulinKunzwisisa

• Kuchinja mararamiro: kuderedza uremu (kuderedza uremu 5-10% kunovandudza zvikuru mafuta echiropa), kudya kusina makabhohaidhiretsi akawanda/mafuta mashoma, kurovedza muviri.
• Mishonga:
  • IinsulinsZvinosimbisa muviri (semuenzaniso, metformin, pioglitazone) zvinogona kuvandudza metabolism yemafuta muchiropa uye shuga.
  • Mishonga yeGLP-1 receptor agonists (semuenzaniso, liraglutide, semaglutide) inobatsira mukuderedza uremu, kudzora glycemic, uye kuderedza mafuta echiropa.
• Kutarisa: Kutsanyainsulin, HOMA-IR (insulin resistance index), HbA1c uye liver imaging/elastography zvaiongororwa nguva nenguva.

Mhedziso

Chiropa chine mafuta uye insulin (kana kuti hyperinsulinemia) inogadzira dambudziko guru kuburikidza nekusakwanisa insulin. Kupindira kwekutanga kweinsulinKusagona kuramba muviri kunovandudza kushandiswa kwemafuta muchiropa neglucose uye kunoderedza njodzi yechirwere cheshuga ne fibrosis yechiropa. Zviratidzo zvemetabolic zvinofanirwa kuongororwa pamwe chete mukiriniki pane kutarisa pane chiratidzo chimwe chete.

Isu Baysen Medical tinogara tichitarisa pakuongorora kuti tivandudze hupenyu. Takagadzira mapuratifomu mashanu etekinoroji - Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, OurKuongororwa kweHbA1c,Kuedzwa kweInsulinuyeKuongororwa kweC-peptide kushanda kuri nyore uye unogona kuwana mhedzisiro yebvunzo mumaminitsi gumi nemashanu