Non-Invasive Testing Kubudirira:Fecal Calprotectin"Kuyambuka Miganho" Kubatsira Kuongororwa Kwekutanga kweUpper GI Kuzvimba muVana

Mundima yekuongorora zvirwere zvevana digestive system, endoscopy yagara iri "yegoridhe mwero" wekutarisa kuzvimba kwekumusoro kwegumbo. Zvisinei, iyi invasive yekuongorora haisi kungoperekedzwa nekusagadzikana kwemuviri kwevana, kunyanya vaduku, asiwo kazhinji kunounza kutya kukuru kwepfungwa uye kuoma kwekubatana. Izvi zvinoita kuti vabereki vakawanda vazengurire panguva yekuongororwa kwekutanga uye vanogona kupotsa mukana wekukurumidza kupindira.Munguva pfupi yapfuura, tsvakurudzo itsva yekliniki uye kushandiswa kwekushandisa kwakaunza nhau dzinofadza:fecal calprotectin (FCP), chiratidzo chekukura chisingaiti chekuongorora zvirwere zvakaderera zvepamuviri, iri kuratidza kukwanisa kukuru mukutanga kuongororwa kwepamusoro pekuputika kwepamuviri muvana, kuwana "crossover" inoshamisa kubva "mudumbu rezasi" kusvika "mudumbu repamusoro".

Kubva paDilemma ye "Gold Standard" kusvika paMambakwedza eNon-Invasive Testing

Upper gastrointestinal kuzvimba senge gastritis uye gastroduodenitis hazvishamisi muvana, uye zvikonzero zvavo zvinosanganisira kutapukira, zvinodhaka, uye kusagadzikana. Sechinyakare, kuongororwa kunoda kutariswa kwekuona uye tishu biopsy kuburikidza negastroscopy, inova yakaoma uye invasive maitiro. Nzira dzekuona dzisingapindi uye dziri nyore dzagara dziri tarisiro yevarapi nemhuri dzevana vane chirwere ichi.Fecal calprotectinipuroteni inoratidza neutrophil aggregation. Kana gastrointestinal mucosa ichipisa, kuwedzera kwayo kuchawedzera zvakanyanya. Kwemakore, yakashandiswa zvakanyanya mukuongorora kwekuita kwechirwere chechirwere chechirwere (IBD) uye kusiyanisa kuongororwa kwechirwere chinogumbura (IBS), kunyanya nokuda kwekuzvimba kwekoloni.

Tsvagiridzo yesainzi inosimbisa hwaro hwakasimba hwe "cross-border" application

Boka rinokura rekutsvagisa rinoratidza kuti ichi chiratidzo chekuzvimba hachisi chega kukoloni. Kana kupisa kunoshanda kunoitika mudumbu repamusoro (senge mudumbu uye duodenum), masero ekuputika anopindawo uye anoburitsa.calprotectin. Iyi puroteni inofamba ichidzika nemudumbu pamwe chete nemvura inogayiwa uye zvisaririra zvekudya, pakupedzisira ichionekwa muchigaro. Zvidzidzo zvenguva pfupi yapfuura muvana zvakaratidza izvozvofecal calprotectinmazinga akanyanya kukwirira muvana vane endoscopically yakasimbiswa gastritis kana duodenitis kana ichienzaniswa nevaya vane dyspepsia inoshanda kana zvakajairika endoscopic zvakawanikwa.Kunyange iyo yakakwira FC mazinga anokonzerwa nepamusoro egastrointestinal kuzvimba kazhinji akaderera pane ayo anoshanda IBD, ivo vakaratidza nhamba yakakura misiyano ichienzaniswa nevanhu vane hutano. Izvi zvinoratidza kuti kuongororwa kweFC kunogona kushandiswa sechishandiso chekuongorora chekubatsira vanachiremba kutanga kuona vana vari panjodzi huru yekuzvimba mukati mehuwandu hwevana vanouya nezviratidzo zvakaita sekurwadziwa kwemudumbu, kuputika, uye kusvotwa.

Clinical Value: Kuvaka Zvirinani Pediatric Diagnostic Pathway

The cross-border application yefecal calprotectinyakaunza akawanda mabhenefiti pakuongororwa uye manejimendi ekumusoro gastrointestinal zvirwere muvana:

1.Non-invasive uye yakakwirira kutevedza: Chengetedza chidimbu chechigaro chechigaro chinodiwa, uye nzira yacho haina zvachose, iyo inoderedza zvikuru mutoro wepanyama uye wepfungwa pavana. Vabereki vari kubvuma zvikuru maitiro, zvichiita kuti zvive nyore kukurumidza kuita kudzokororwa kuongorora mumakiriniki ekunze.
2. Chishandiso chinoshanda chekuongorora uye chekuongorora: Kune vana vane zviratidzo zvemudumbu zvinoramba zvichiitika,Fecal Calprotectinkuongororwa kunogona kuitwa kutanga kunyatsosiyanisa pakati pezvirwere zvinopisa uye zvinoshanda. KanaFecal calprotectinmazinga akajairika, mashandiro anoita zvinhu anogona kuiswa pamberi kana empirical kurapwa uye kutarisa kunogona kugamuchirwa. Kana mazinga eFC akakwidziridzwa, inopa hwaro hwakasimba hwe invasive gastroscopy, kudzivirira zvisina kufanira endoscopic maitiro uye optimize kugoverwa kwezviwanikwa zvekurapa.
3. Kubatsirwa kuongororwa kwekubudirira uye kudzoka zvakare: Mushure mekuongororwa kwepamusoro pekuputika kwepamuviri uye kutanga kwekurapa, kuongorora kwakasimba kwekuchinja mu.Fecal Calprotectinmazinga anogona kushanda sechiratidzo chekutarisa chekutarisa kana kuzvimba kwadzikira uye kana kurapwa kuri kushanda. Zvinogonawo kubatsira kuona kudzoka kwechirwere nekukurumidza.

Ramangwana Outlook

Hongu, kushandiswa kwefecal calprotectin munzvimbo yepamusoro yegumbo kuchiri kuda kumwe kutsvakurudza kuti inyatsotsanangura kukosha kwayo kwekucheka uye kubvisa zvimwe zvinhu zvakaderera zvedumbu zvinogona kukonzera FC yakakwirira. Zvisinei, senzira yakachengeteka, yakapfava, uye yakachipa yekuongorora, pasina mubvunzo inovhura musuwo mutsva wekuongororwa kwekutanga kwekuzvimba kwegumbo muvana. Inotaridza nhanho yekumberi mukuongororwa kwezvirwere zvekugaya kwevana kune imwe nzira ine hunhu uye chaiyo. Isu tinotenda kuti nekuenderera mberi kwekutsvaga kwakadzama uye kuunganidza ruzivo rwekiriniki,fecal calprotectin,iyi "crossover star," ichaita basa rinokosha rinowedzera mukudzivirira utano hwekudya kwevana.

Baysen Medical inogara yakatarisa nzira yekuongorora yekuvandudza hupenyu. Takagadzira mapuratifomu mashanu ehunyanzvi- Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular,Chemiluminescence Immunoassay.Tine Colloidal GoldFecal calprotectin test kit uye Fluorescence ImmunoassayCalprotectin test kityekuongororwa