Calprotectin yetsvinaChishandiso Chinokosha Chekuongorora Kusiyanisa Kwezvirwere Zvemudumbu

Mukurapa, kuongororwa kwezvirwere zvemudumbu kunowanzo kuve nematambudziko, sezvo zvirwere zvakawanda (zvakaita sechirwere chemudumbu chinoputika, chirwere chemudumbu chinokatyamadza, uye chirwere chemudumbu chinotapukira) zvine zviratidzo zvakafanana, zvichiita kuti kusiyana kwacho kuve kwakaoma zvichibva chete pazviratidzo zvekiriniki uye kuongororwa kwakajairika.Fecal calprotectin (FC), chiratidzo chisingapindi mishonga, chine simba rakawanda, chakaratidza kukosha kukuru mukuongororwa kwakasiyana kwezvirwere zvemudumbu zvishoma mumakore achangopfuura, chikava chishandiso chinoshanda chekubatsira pakusarudza kwekiriniki.

Chii Calprotectin yetsvina?

Calprotectin ipuroteni inowanikwa mu cytoplasm yema neutrophils. Kana kuzvimba kwemudumbu kukaitika, ma neutrophils anotamira ku mucosa yemudumbu oburitsa calprotectin, zvichiita kuti huwandu hwayo mutsvina huwedzere zvakanyanya. Nekuda kwekugadzikana kwayo kwakanyanya uye nyore kuona, FC inoratidza mazinga ekuzvimba kwemudumbu, zvichibatsira kusiyanisa pakati pezvirwere zvemudumbu zvinozvimba (semuenzaniso, IBD) uye zvirwere zvisina kuzvimba (semuenzaniso, IBS).

Zvishandiso muKuongorora Kusiyana

1. Kusiyanisa pakati pechirwere chemudumbu chinoputika (IBD) nechirwere chemudumbu chinokatyamadza (IBS)
   IBD (kusanganisira chirwere cheCrohn neulcerative colitis) chirwere chisingaperi chekuzvimba mudumbu, nepo IBS chirwere chinoshanda chisina maronda emuviri. Mazinga eFC anowanzo wedzera zvakanyanya muvarwere veIBD (kazhinji vanodarika 100 μg/g), nepo avo vari muIBS kazhinji vari mukati mehuwandu hwakajairika (pasi pe50 μg/g). Nokudaro, bvunzo dzeFC dzinogona kushanda senzira yekutanga yekuongorora, kuderedza nzira dzisina basa dze endoscopic, kuderedza mari yehutano, uye kuvandudza kushanda zvakanaka kwekuongorora.
2. Kuongororwa kwebasa rechirwere cheIBD

Mazinga eFC anoenderana zvakanaka nekushanda kwechirwere muIBD. Kuramba uchitarisa FC kunobatsira kuongorora kushanda kwekurapa uye kufanotaura kudzokera shure. Semuenzaniso, kudzikira kweFC panguva yekurapwa kunoratidza kuzvimba kwakadzorwa, nepo kuwedzera kwakawedzerwa kunogona kuratidza kudzoka kwechirwere, zvichitungamira kugadziriswa kwenzira dzekurapa.

3.Kusiyanisa chirwere che enteritis chinotapukira kubva kune zvimwe zvirwere zvinozvimba

Kurwara kwechirwere cheEnteritis (senge bhakitiriya kana kuti hutachiona) kunogonawo kukonzera kuwedzera kweFC, asi huwandu hwechirwere hunowanzova hwakaderera pane hweIBD uye hunoderera nekukurumidza sezvo hutachiona hwacho huchipera. Kutarisa kwakasimba kweFC kunobatsira kusiyanisa hutachiona hwenguva pfupi kubva kuzvirwere zvisingaperi zvekuzvimba.

4. Kuongororwa Kwekubatsira kweKenza yeColorectal

Kunyangwe FC isiri chiratidzo chaicho chegomarara remudumbu, bundu remudumbu rinowanzo sanganisira kuzvimba kwemuviri, zvichikonzera kukwira kuri pakati nepakati muFC. Kana ikasanganiswa nedzimwe bvunzo (semuenzaniso, colonoscopy), FC inogona kupa rumwe ruzivo rwekuongorora chirwere.

Zvakanakira uye Zvisina Kukwana

Kuongororwa kweCalprotectin yetsvina inopa zvakanakira zvakaita sekusapinda mumuviri, nyore kushandisa, uye mutengo wakaderera, zvichiita kuti ive yakakodzera kuongororwa kwekutanga uye kutariswa kwenguva refu.Kalori yetsvina Hazvina kunyanya kukonzera IBD uye zvinogona kuonekwawo mune zvimwe zvirwere (zvakadai sezvirwere zvemudumbu, bundu, uye mishonga inodzivirira kuzvimba isiri yesteroidal). Saka, kuongororwa kwakazara kwakavakirwa pazviratidzo zvekiriniki, kuongororwa kwe endoscopic, uye zvidzidzo zvemifananidzo kunodiwa.

Mhedziso

Calprotectin yetsvina Kuongororwa kunopa hwaro hwakakosha hwekusiyanisa kuongororwa kwezvirwere zvemudumbu, kunyanya kubatsira kusiyanisa IBD neIBS uye kugadzirisa kuongororwa nekurapwa. Nekufambira mberi muhunyanzvi hwekuongorora uye mashandisirwo akadzama ekiriniki,calprotectin yetsvina zvichabatsira zvikuru mukurapa zvirwere zvemudumbu, zvichipa varwere ruzivo rwakarurama uye runoshanda uye kurapwa.

Nekushandisa sainzicalprotectin yetsvinaSechishandiso, tinogona kubatsira zviri nani pakuongorora chirwere uye kubatsira mukutarisira nekurapa zvirwere zvemudumbu.

Baysen MedicalChinangwa chedu ndechekutarisa nzira dzekuongorora kuti tivandudze hupenyu. Takagadzira mapuratifomu mashanu etekinoroji - Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Kuedza nekukurumidza kweCalprotectinuyeInibvunzo yeCalprotectin yekuongorora kukuvara kweitsvo padanho rekutanga.