Ferritin: Inokurumidza uye Yakarurama Biomarker Yekuongorora Iron Kushaya uye Anemia

Nhanganyaya

Kushaikwa kwesimbi uye anemia ndiwo matambudziko akajairika ehutano pasi rose, kunyanya munyika dzichiri kusimukira, vakadzi vane pamuviri, vana nevakadzi vezera rekubereka. Iron deficiency anemia (IDA) haingokanganisa basa remuviri uye rekuziva kwevanhu, asi inogonawo kuwedzera njodzi yekubata pamuviri uye kunonoka kukura muvana. Naizvozvo, kuongororwa kwekutanga uye kupindira kwakakosha. Pakati pezvizhinji zviratidzo zvekuona, ferritin yave chishandiso chakakosha chekutarisa kushomeka kwesimbi uye anemia nekuda kwekunzwa kwayo kwakanyanya uye kujeka. Ichi chinyorwa chichakurukura maitiro ebhayoloji eferritin, zvakanakira mukuongororwa kwekushaya iron uye anemia, uye kukosha kwayo kwekiriniki yekushandisa.

Biological Hunhu hweFerritin

Ferritinipuroteni yekuchengetedza simbi inowanikwa zvakanyanya munyama dzevanhu. Inonyanya kugadzirwa nechiropa, spleen uye bone marrow. Basa rayo guru nderekuchengetedza iron uye kugadzirisa kuenzana kwesimbi metabolism. Muropa, kuwanda kweferritininodyidzana zvakanaka nesimbi inochengeterwa nemuviri. Saka, serumferritinmazinga ndechimwe chezviratidzo zvinonyanya kunzwisiswa zvechimiro chemuviri chekuchengetedza iron. Mumamiriro ezvinhu akajairika, chiyero cheferritin muvarume vakuru chinenge 30-400 ng / mL, uye muvakadzi ndeye 15-150 ng / mL, asi munyaya yekushayikwa kwesimbi, kukosha uku kuchaderedzwa zvakanyanya.

Zvakanakira zveFerritinmuIron Deficiency Screening

1. Kunzwa kwepamusoro, kuonekwa kwekutanga kwekushayikwa kwesimbi

Kukura kwekushaiwa iron kwakakamurwa kuita matanho matatu:

• Iron deficiency stage: simbi yekuchengetedza(ferritin) inoderera, asi hemoglobin yakajairika;
• Iron deficiency erythropoiesis stage:ferritininowedzera kuderera, transferrin saturation inoderera;
• Iron deficiency anemia stage: hemoglobin inoderera, uye zviratidzo zveanemia zvinowanzoitika.

Nzira dzechinyakare dzekuongorora (dzakadai sekuongorora hemoglobin) dzinogona kungoona matambudziko muchikamu cheanemia, nepoferritinkuongororwa kunogona kuona kusagadzikana muchikamu chekutanga chekushayikwa kwesimbi, nekudaro ichipa mukana wekukurumidza kupindira.

2. High Specificity, Kuderedza Misdiagnosis

Zvirwere zvakawanda (sekuzvimba kusingaperi uye hutachiona) zvinogona kukonzera kupererwa neropa, asi hazvikonzerwe nekushaikwa kwesimbi. Muchiitiko ichi, kuvimba chete nehemoglobini kana kureva corpuscular volume (MCV) inogona kukanganisa chikonzero chacho.Ferritinkuongororwa kunogona kunyatsosiyanisa kushayikwa kwesimbi anemia kubva kune mamwe marudzi eanemia (akadai seanemia yechirwere chisingaperi), kuvandudza kuongororwa kwechokwadi.

3. Inokurumidza uye yakanakira, yakakodzera kutarisisa yakakura

Tekinoroji yemazuva ano yekuongorora biochemical inoita kuti ferritin ikurumidze uye iwedzere hupfumi, uye inokodzera zvirongwa zvehutano zveveruzhinji zvakaita sekuongorora nharaunda, hutano hwaamai nevacheche, uye kutarisa kwekudya kwevana. Kuenzaniswa nemiedzo inoparadza senge bone marrow iron staining (yegoridhe chiyero), serum ferritin bvunzo iri nyore kukurudzira.

Clinical Applications yeFerritin muAnemia Management

1. Kutungamira simbi yekuwedzera kurapwa

Ferritinmazinga anogona kubatsira vanachiremba kuona kana varwere vachida iron supplementation uye kutarisa kushanda kwekurapa. Semuyenzaniso:

• Ferritin<30 ng/mL: inoratidza kuti matura esimbi apera uye iron supplement inodiwa;
• Ferritin<15 ng/mL: inoratidza zvakasimba kushayikwa kwesimbi anemia;
• Kana kurapwa kunoshanda, ferritin mazinga anozokwira zvishoma nezvishoma uye anogona kushandiswa kuongorora kushanda

1. Kutungamira Iron Supplementation

Ferritinmazinga anobatsira varapi kuona kudiwa kwesimbi kurapwa uye kutarisa kushanda kwekurapa. Semuyenzaniso:

• Ferritin<30 ng/mL: Inoratidza zvitoro zvesimbi zvakapera, zvinoda kuwedzerwa.
• Ferritin<15 ng/mL: Inonyatsoratidza kushayikwa kwesimbi anemia.
• Panguva yekurapa, kusimukaferritinmazinga anosimbisa kushanda kwekurapa.

2. Kuongororwa kwehuwandu hwevanhu

• Vakadzi vane pamuviri: kudiwa kwesimbi kunowedzera panguva yekuzvitakura, uyeferritinkuongororwa kunogona kudzivirira matambudziko aamai uye mucheche.
• Vana: kushomeka kwesimbi kunokanganisa kukura kwekuziva, uye kuongororwa kwekutanga kunogona kuvandudza kufungidzira.
• Varwere vane zvirwere zvisingaperi: sevarwere vane chirwere cheitsvo uye chirwere chinoputika,ferritin yakasanganiswa netransferrin saturation inogona kuona rudzi rweanemia.

Kuganhurirwa kweFerritinTesting uye Solutions

Kunyangwe ferritin iri iyo inosarudzika chiratidzo chekushomeka kwesimbi kuongororwa, inoda kududzirwa nekuchenjerera mune dzimwe nguva:

• Kuzvimba kana utachiona:Ferritin, seacute phase reactant protein, inogona kunge yakasimudzwa zvenhema muhutachiona, bundu kana kusingaperi kuzvimba. Muchiitiko ichi, inogona kusanganiswa neC-reactive protein (CRP) ortransferrinkuzara kwekutonga kwakakwana.
• Chirwere chechiropa:Ferritinmuvarwere vane cirrhosis inogona kuwedzera nekuda kwekukuvara kwemasero echiropa uye inoda kuongororwa pamwe chete nezvimwe zviratidzo zvesimbi metabolism.

Mhedziso

Ferritinkuyedza kwave chishandiso chakakosha chekutarisa kushomeka kwesimbi uye anemia nekuda kwekunzwa kwayo kwakanyanya, kujeka uye nyore. Iyo haigone kungoona kushomeka kwesimbi nekukurumidza uye kudzivirira kufambira mberi kweanemia, asi zvakare kutungamira kurapwa kwakanyatso uye kugadzirisa kufungidzira kwemurwere. Muhutano hweveruzhinji uye maitiro ekiriniki, kusimudzirwa kweferritin kuongororwa kunogona kubatsira kuderedza mutoro wechirwere chesimbi inoshaya anemia, kunyanya kumapoka ane ngozi (akadai sevakadzi vane pamuviri, vana uye varwere vane zvirwere zvisingaperi). Mune ramangwana, nekufambira mberi kwehunyanzvi hwekuona,ferritin inogona kuita basa rakakura mukudzivirira uye kutonga kweanemia pasi rose.

Isu Baysen Medical inogara yakatarisa nzira yekuongorora yekuvandudza hupenyu. Takagadzira 5 tekinoroji mapuratifomu- Latex, colloidal goridhe, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, Yedu.Ferritin test kit nyore kushanda uye unogona kuwana bvunzo mhinduro mumaminitsi gumi nemashanu