C-Reactive Protein (CRP) ipuroteni inogadzirwa nechiropa, uye huwandu hwayo muropa hunokwira zvakanyanya nekuda kwekuzvimba. Kuwanikwa kwayo muna 1930 uye ongororo yakatevera yakasimbisa basa rayo seimwe yezviratidzo zvakakosha uye zvinoshandiswa zvakanyanya mukurapa kwemazuva ano. Kukosha kwekuongororwa kweCRP kuri mukushanda kwayo sechiratidzo chekuzvimba chinonzwisisika, kunyange chisina kujeka, chinobatsira mukuongorora, kupatsanura njodzi, uye kutarisa zvirwere zvakasiyana-siyana.

1. Chiratidzo Chinonzwisisika cheUtachiona neKuzvimba
Imwe yenzira huru dzekushandisa CRP ndeyekuona nekutarisira hutachiona, kunyanya hutachiona hwebhakitiriya. Kunyange hazvo kuwedzera kweCRP kuri mhinduro yekuzvimba, huwandu hunogona kukwira zvakanyanya muhutachiona hwakasimba hwebhakitiriya, hunowanzo pfuura 100 mg/L. Izvi zvinoita kuti ive yakakosha mukusiyanisa hutachiona hwebhakitiriya nehutachiona, sezvo hwekupedzisira hunowanzo kukonzera kukwira kuri pakati nepakati. Munzvimbo dzekiriniki, CRP inoshandiswa kuongorora mamiriro akaita sepneumonia, sepsis, uye hutachiona hwepashure pekuvhiyiwa. Semuenzaniso, kutarisa huwandu hweCRP mushure mekuvhiyiwa kunobatsira vanachiremba kuona matambudziko akadai sehutachiona hwemaronda kana maronda akadzika pakutanga, zvichibvumira kupindira nekukurumidza. Inobatsirawo mukurapa zvirwere zvisingaperi zvekuzvimba senge rheumatoid arthritis uye chirwere chemudumbu chinoputika (IBD), uko kuyerwa kwakatevedzana kunobatsira kuona mashandiro echirwere uye kushanda kwekurapa kwekudzivirira kuzvimba.

2. Kuongororwa kweNjodzi dzeMwoyo neMitsipa yeMwoyo: hs-CRP
Kufambira mberi kukuru mumunda uyu kwaive kuvandudzwa kwekuongororwa kweCRP (hs-CRP) ine hunhu hwakanyanya. Kuongororwa uku kunoyera huwandu hwakaderera hweCRP, hwaisamboonekwa kare. Tsvagiridzo yakaratidza kuti kuzvimba kwenguva refu, kusingawanzoonekwi mukati memadziro etsinga ndiko kunokonzera atherosclerosis—kuunganidzwa kweplaque kunogona kutungamira kurwiswa kwemwoyo nestroke. hs-CRP inoshanda sechiratidzo chakasimba chekuzvimba kwetsinga idzi.
Sangano reAmerican Heart Association rinoona hs-CRP sechinhu chakazvimiririra chinokonzera chirwere chemwoyo. Vanhu vane huwandu hwehs-CRP huri pamusoro pe3 mg/L vanoonekwa sevane njodzi yakakura yezviitiko zvemwoyo mune ramangwana, kunyangwe huwandu hwecholesterol yavo hwakajairwa. Nekuda kweizvozvo, hs-CRP inoshandiswa kunatsiridza kuongororwa kwenjodzi, kunyanya kune varwere vane njodzi yepakati. Izvi zvinobvumira nzira dzekudzivirira dzakagadzirwa nemunhu, dzakadai sekutanga kurapwa nestatin muvanhu vangadai vasina kurapwa zvichibva pazvinhu zvengozi zvechinyakare chete.

3. Kutarisa Mhinduro dzeKurapwa uye Kufungidzira
Kupfuura kuongororwa uye kuongororwa kwenjodzi, CRP chishandiso chakanakisa chekutarisa mhinduro yemurwere kukurapa. Muzvirwere zvinotapukira, kudzikira kweCRP chiratidzo chakasimba chekuti mushonga wemishonga inorwisa mabhakitiriya kana mishonga inorwisa mabhakitiriya unoshanda. Saizvozvowo, mumamiriro ezvinhu ekudzivirira muviri, kudzikira kweCRP kunoenderana nekudzora kuzvimba nekubudirira nemishonga inodzvinyirira immune system. Hunhu uhwu hunobvumira vanachiremba kugadzirisa zvirongwa zvekurapa munguva chaiyo. Uyezve, huwandu hweCRP hwakakwira hunowanzobatanidzwa nekufanotaura kwakaipa mumamiriro ezvinhu akasiyana-siyana kubva kukenza kusvika kukutadza kwemoyo, zvichipa mukana wekuona kuoma kwechirwere uye nzira yacho.

Miganhu uye Mhedziso
Pasinei nekushanda kwayo, chinhu chakakosha paCRP ndechekuti haina kunyatsotsanangurwa. Kukwira kwehuwandu hwechirwere kunoratidza kuvapo kwekuzvimba asi hakuzivikanwi chikonzero chacho. Kushushikana, kukuvara, kufuta, uye zvirwere zvisingaperi zvinogona kuwedzera CRP. Saka, mhedzisiro yacho inofanira kugara ichitsanangurwa zvichienderana nenhoroondo yemurwere, kuongororwa kwemuviri, nezvimwe zvakawanikwa pakuongororwa.

Mukupedzisa, kukosha kwekuongororwa kweCRP kune mativi akawanda. Kubva pakushanda sebvunzo yepamberi yehutachiona hwakasimba kusvika pakushanda sechiratidzo chakasimba chenjodzi yenguva refu yemwoyo kuburikidza nehs-CRP, iyi biomarker chishandiso chakakosha muzvigadzirwa zvechiremba. Kugona kwayo kuyera nekutarisa kuzvimba kwakanyatso vandudza kutarisirwa kwevarwere mukuongorora, nhungamiro yekurapa, uye kuongororwa kwekufanotaura pakati pehunyanzvi hwekurapa hwakasiyana-siyana.