C-Reactive Protein (CRP) ipuroteni inogadzirwa nechiropa, uye mazinga ayo muropa anokwira zvakanyanya mukupindura kuzvimba. Kuwanikwa kwayo muna 1930 uye ongororo yakatevera yakasimbisa basa rayo seimwe yeakakosha uye anoshandiswa zvakanyanya biomarker mukurapa kwemazuva ano. Kukosha kwekuyedzwa kweCRP kuri mukushandisa kwayo seyakajeka, kunyangwe isiri-yakananga, chiratidzo chekuzvimba, kubatsira mukuongororwa, njodzi stratification, uye kutarisisa huwandu hwakakura hwemamiriro.

1. A Sensitive Marker for Infection and Inflammation
Imwe yemashandisirwo ekutanga eCRP ndeyekuona uye kutonga kwehutachiona, kunyanya hutachiona hwehutachiona. Nepo kukwira kweCRP kuri mhinduro yakajairika mukuzvimba, mazinga anogona kukwira muhutachiona hwakanyanya hwebhakitiriya, kazhinji hunodarika 100 mg/L. Izvi zvinoita kuti ive yakakosha mukusiyanisa bhakitiriya kubva kune hutachiona hwehutachiona, sezvo hwekupedzisira hunowanzo konzera kukwirira kwakadzikama. Munzvimbo dzekiriniki, CRP inoshandiswa kuongorora mamiriro akaita sepneumonia, sepsis, uye hutachiona hwepashure-kuvhiya. Semuenzaniso, kutarisa CRP mazinga mushure mekuvhiyiwa kunobatsira varapi kuona matambudziko akadai sehutachiona hwemaronda kana mazamu akadzika nekukurumidza, zvichibvumira kupindira nekukurumidza. Izvo zvinobatsirawo mukugadzirisa zvirwere zvisingaperi zvekuzvimba senge rheumatoid arthritis uye inflammatory bowel chirwere (IBD), uko kuyerwa kwe serial kunobatsira kuyera chiitiko chechirwere uye kushanda kweanti-inflammatory therapy.

2. Cardiovascular Risk Assessment: hs-CRP
Kufambira mberi kukuru mumunda kwaive kuvandudzwa kwepamusoro-senzwi CRP (hs-CRP) bvunzo. Muedzo uyu unoyera mazinga akaderera eCRP, ayo akange asingaonekwe kare. Tsvagiridzo yakaratidza kuti kusingaperi, kuderera kwegiredhi kuzvimba mukati memadziro emadziro ndicho chinhu chikuru chinotyaira atherosclerosis-kuvakwa kweplaque inogona kutungamirira kukurwisa kwemoyo uye sitiroko. hs-CRP inoshanda seyakasimba biomarker yeiyi iri pasi pevascular kuzvimba.
IAmerican Heart Association inoziva hs-CRP sechinhu chakazvimirira chengozi yechirwere chemoyo. Vanhu vane hs-CRP mazinga mu-high-normal range (pamusoro pe3 mg / L) vanoonekwa sevari pangozi yezviitiko zvemwoyo zvemangwana, kunyange kana mazinga avo echolesterol ari akajairika. Nekuda kweizvozvo, hs-CRP inoshandiswa kunatsiridza kuongororwa kwenjodzi, kunyanya kune varwere vane njodzi yepakati. Izvi zvinobvumira mamwe maitiro ekudzivirira ega ega, akadai sekutanga statin therapy muvanhu vangangove vasina kurapwa zvichibva pachinyakare njodzi zvinhu chete.

3. Monitoring Treatment Response uye Prognosis
Kupfuura kuongororwa uye kuongororwa kwenjodzi, CRP chishandiso chakanakisa chekutarisa mhinduro yemurwere pakurapwa. Muzvirwere zvinotapukira, kudonha kweCRP nhanho chiratidzo chakasimba chekuti antibiotic kana antimicrobial therapy inoshanda. Saizvozvo, mune autoimmune mamiriro, kuderera kweCRP kunoenderana nekubudirira kudzvinyirira kwekuzvimba ne immunosuppressive zvinodhaka. Ichi chimiro chine simba chinobvumira varapi kugadzirisa zvirongwa zvekurapa munguva-chaiyo. Uyezve, kuramba kwakakwirira kweCRP mazinga anowanzobatanidzwa nehutachiona hwakaipisisa mumamiriro ezvinhu kubva kune kenza kusvika kukushaya mwoyo, kupa hwindo mukuoma kwechirwere uye trajectory.

Kugumira uye Mhedziso
Pasinei nekushandisa kwayo, chinodzikisira chakakosha cheCRP kusataura kwayo. Chiyero chakakwira chinoratidza kuvepo kwekuzvimba asi hachinongedze chakakonzera. Kushushikana, kushungurudzika, kufutisa, uye zvisingaperi mamiriro anogona kusimudza CRP. Nokudaro, migumisiro yaro inofanira kugara ichidudzirwa mumamiriro ezvinhu ehutano hwehutano hwemurwere, kuongororwa kwemuviri, uye zvimwe zviwanikwa zvekuongorora.

Mukupedzisa, kukosha kwekuyedzwa kweCRP kune akawanda. Kubva pakuita semuyedzo wepamberi wezvirwere zvakakomba kusvika pakushanda seanofembera enguva refu yenjodzi yemoyo kuburikidza nehs-CRP, iyi biomarker chishandiso chakakosha mune arsenal yemukiriniki. Kugona kwayo kuyera zvine mutsindo uye kutarisa kuzvimba kwakavandudza zvakanyanya kutarisirwa kwevarwere mukuongororwa, kutungamira kurapwa, uye kuongororwa kwekufungidzira kune akawanda ekurapa hunyanzvi.