Cardiac Troponin T (cTnT), chikamu chidiki chetroponin complex chinoratidzwa chete muma "cardiac myocytes", chinomira sechimwe chezvinhu zvinonyanya kuchinja uye zvisingakoshi mukurapa kwemwoyo kwemazuva ano. Kukosha kwayo kwakavakirwa pakusiyana kwayo kwemwoyo, kunzwa kwakanyanya, uye basa rayo guru mukuongorora, kupatsanura njodzi, uye kutarisira acute coronary syndromes (ACS) nedzimwe kukuvara kwemoyo.

Chinonyanya kukosha, cTnT ndiyo chiratidzo chikuru chekuongorora chirwere chemyocardial infarction (MI). Vasati vatora troponin, kuongororwa kwacho kwaitsamira pazviratidzo zvisinganyanyi kutaurwa zvakaita seCreatine Kinase-MB (CK-MB) uye zviratidzo zvekiriniki, zvichikonzera kusaziva kuti chirwere ichi chinobuda sei. Kuburitswa kwe cTnT muropa mushure mekubuda kwechirwere chemyocardial kwakanangana zvakanyanya nekukuvara kwetsandanyama dzemwoyo. Kuuya kwekuongorora kwe troponin T (hs-cTnT) kwakawedzera kuchinja nzvimbo iyi. Kuongororwa uku kunogona kuona kukwira kwe cTnT zvishoma pasi pe99th percentile upper reference limit yevanhu vakajairwa. Izvi zvinobvumira vanachiremba kuona kukuvara kwemyocardial kare kare—kazhinji mukati memaawa 1-3 ekuratidzwa kwechipatara che emergency—zvichibvumira kukurumidza kudzorwa uye, zvakakosha, kukurumidza uye kuvimba nekubviswa kwechirwere chemyocardial. Izvi zvinokurumidzisa kurapwa kwechokwadi uye zvinosunungura varwere vane njodzi shoma, zvichivandudza kushanda zvakanaka kwechipatara che emergency uye kufamba kwevarwere.

Kunze kwekuongororwa, cTnT ine basa guru mukupa mukana wekuona njodzi uye kufanotaura kwayo. Hukuru hwekuwedzera kwe cTnT hunoenderana zvakanyanya nehukuru hwekukuvara kwemoyo uye chiratidzo chakasimba chemhedzisiro yakaipa yenguva pfupi uye refu, kusanganisira kutadza kwemoyo, kudzoka kwekufa, uye kufa. Kunyangwe kukwirira kudiki, kwenguva refu kunoonekwa nekuyedzwa kwe hs-cTnT muvarwere vanoita sevakasimba kunogona kuona avo vane kukuvara kwemoyo kusingaonekwe, zvichiratidza njodzi yakakura yezviitiko zvemoyo mune ramangwana. Izvi zvinoita kuti cTnT ive chishandiso chakakosha kwete chete munzvimbo dzakakomba asiwo mukugadzirisa zvirwere zvisingaperi senge chirwere chemwoyo chakagadzikana, kutadza kwemoyo, uye chirwere cheitsvo chisingaperi.

Uyezve, kuyerwa kwe cTnT kunotungamira pakusarudza kwakakosha pakurapa. Maitiro ekuwedzera uye/kana kudzikira kwe cTnT akakosha kuti uzive MI inokurumidza zvichienderana nemirairo yepasi rose. Kusimbiswa uku kwe biochemical kunozivisa zvakananga kupindira kwekukurumidzira kwakadai se coronary angiography uye revascularization (PCI kana CABG). Zvinobatsirawo pakusarudza nekutarisa kushanda kwemishonga, kusanganisira mishonga ine simba yekudzivirira maplatelet (semuenzaniso, ticagrelor, prasugrel) uye mishonga inorwisa maronda.

Kukosha kwe cTnT kunosvika kune zvirwere zvemwoyo zvisina ischemic. Kuwanda kwacho kunoonekwa muzvirwere zvakasiyana-siyana apo myocardial strain kana kukuvara kunoitika, zvakaita se myocarditis, cardiac contusion, sepsis yakanyanya, pulmonary embolism inokonzera right heart strain, uye cardiotoxicity inokonzerwa ne chemotherapy. Mumamiriro ezvinhu aya, cTnT inoshanda sechiratidzo chekupindira kwemoyo, zvichiita kuti pave nekuferefetwa kwakawanda uye kutarisirwa kwakakodzera.

Mukupedzisa, Cardiac Troponin T yakachinja zvakanyanya tsika yekurapa mwoyo. Kushanduka kwayo kuita bvunzo yemhando yepamusoro kwakasimbisa chinzvimbo chayo sechiratidzo chikuru chekukuvara kwemoyo. Nekupa kururama kusingaenzaniswi kwekuongororwa, ruzivo rwakasimba rwekufanotaura, uye gwara rakakosha rekurapa kunoponesa hupenyu, cTnT inokosha pakuvandudza mhedzisiro yevarwere mune emergency yemwoyo uye kurapwa kwenguva refu kwechirwere chemwoyo. Kuyera kwayo chiyero chisingachinjiki mukurapa kwemwoyo kwemazuva ano.