Ururka u dhexeeya Caabuqa Mindhicirka, Gabowga, iyo Cudurka Cudurka Alzheimers

Sanadihii la soo dhaafay, xiriirka ka dhexeeya microbiota mindhicirka iyo cudurrada neerfaha ayaa noqday goob cilmi baaris ah. Cadaymo badan oo badan ayaa muujinaya in caabuqa mindhicirka (sida xuubka dheecaanka iyo dysbiosis) ay saameyn ku yeelan karaan horumarka cudurada neerfayaasha, gaar ahaan cudurka Alzheimers (AD), iyada oo loo marayo "dhidibka maskaxda-maskaxda". Maqaalkani waxa uu dib u eegayaa sida caabuqa mindhicirku u korodho da'da oo uu sahamiyo xidhiidhka suurtogalka ah ee cudurka AD (sida β-amyloid deposition iyo neuroinflammation), siinta fikrado cusub oo loogu talagalay faragelinta hore ee AD.

1. Hordhac

Cudurka Alzheimers (AD) waa xanuunka ugu badan ee neurodegenerative, oo lagu garto β-amyloid (Aβ) plaques iyo hyperphosphorylated tau protein. In kasta oo arrimaha hidde-sidaha (tusaale, APOE4) ay yihiin arrimo waaweyn oo halista AD, saamaynta deegaanka (tusaale, cunto, caafimaadka mindhicirka) waxa kale oo laga yaabaa inay gacan ka geysato horumarka AD iyada oo loo marayo caabuq dabadheeraad ah. Mindhicirku, oo ah xubinta ugu wayn ee difaaca jidhka, waxa laga yaabaa inay saamayn ku yeelato caafimaadka maskaxda iyada oo loo marayo dariiqyo badan, gaar ahaan wakhtiga gabowga.

2. Caabuqa xiidmaha iyo gabowga

2.1 Hoos u dhaca da'da ee shaqada xannibaadda mindhicirka
Da'da, daacadnimada xannibaadda mindhicirka ayaa hoos u dhacda, taasoo keenta "mindhicirka qulqulaya", taas oo u oggolaanaysa dheef-shiid kiimikaadka bakteeriyada (sida lipopolysaccharide, LPS) inay galaan wareegga dhiigga, taasoo kicinaysa barar heer hoose ah oo nidaamsan. Daraasaduhu waxay muujiyeen in kala duwanaanta dhirta mindhicirka ee waayeelka ay hoos u dhacdo, bakteeriyada pro-inflammatory (sida Proteobacteria) ay korodho, iyo bakteeriyada anti-bararka (sida Bifidobacterium) hoos u dhacdo, taas oo sii xumaynaysa jawaabta bararka.

2.2 Qodobbada caabuqa iyo gabowga
Caabuqa heerka hoose ee daba-dheeraada ("gabowga bararka", bararka) waa sifo muhiim ah oo gabowga ah. Qodobbada caabuqa mindhicirka (sidaIL-6, TNF-α) waxay geli kartaa maskaxda iyada oo loo marayo wareegga dhiigga, firfircooni microglia, kor u qaadida neuroinflammation, iyo dardar-socodka pathological AD.

iyo kor u qaadida xanuunka neuroinflammation, taas oo kor u qaadaysa AD pathology.

3. Xidhiidhka Ka Dhaxeeya Caabuqa Mindhicirka iyo Cudurka Cudurka Alzheimers

3.1 Dysbiosis mindhicirka iyo Aβ dhigaalka

Noocyada xayawaanku waxay muujiyeen in khalkhalka dhirta mindhicirku ay kordhin karaan dhigaalka Aβ. Tusaale ahaan, jiirarka la daweeyay antibiyootiga ayaa hoos u dhigay xuubka Aβ, halka heerarka Aβ lagu kordhiyo jiirarka leh dysbiosis. Dheef-shiid kiimikaad qaarkood (sida asiidh dufan ah oo silsilad gaaban ah, SCFAs) ayaa laga yaabaa inay saameeyaan nadiifinta Aβ iyadoo nidaaminaysa shaqada microglial.

3.2 Dhidibka mindhicirka-maskaxda iyo xanuunka neerfaha

Caabuqa mindhicirku wuxuu saameeyaa maskaxda iyada oo loo marayo vagal, habka difaaca jirka, iyo waddooyinka dheef-shiid kiimikaadka:

• Waddada Vagal: Calaamadaha caabuqa mindhicirka waxaa lagu kala qaadaa dareemaha siilka ee CNS, saameynaya hippocampal iyo shaqada kortex prefrontal.
• Caabuqa nidaamka: Qaybaha bakteeriyada sida LPS waxay kiciyaan microglia waxayna kor u qaadaan xanuunka neuroinflammation, ka sii daraya tau pathology iyo dhaawaca neuronal.
• Saamaynta dheef-shiid kiimikaadka: dysbiosis mindhicirku wuxuu saameyn karaa dheef-shiid kiimikaad tryptophan, taasoo horseedaysa dheelitir la'aanta neurotransmitters (tusaale, 5-HT) oo saameeya shaqada garashada.

3.3 Caddayn Caafimaad

• Bukaanka qaba AD aad ayey uga duwan yihiin flora mindhicirka marka loo eego dadka waaweyn ee caafimaadka qaba, tusaale ahaan, saami aan caadi ahayn oo ah phylum-dabi adag/Bakteeriyada phylum.
• Heerarka dhiigga ee LPS waxay si togan ula xiriiraan darnaanta AD.
• Waxqabadyada probiotic (sida Bifidobacterium bifidum) waxay yareeyaan dhigaalka Aβ waxayna wanaajiyaan shaqada garashada ee moodooyinka xayawaanka.

4. Xeeladaha Faragelinta ee suurtagalka ah

Wax ka beddelka cuntada: cunnooyinka fiber-ka sarreeya, cunnada Mediterranean-ka ayaa laga yaabaa inay kor u qaadaan koritaanka bakteeriyada faa'iidada leh waxayna yareeyaan bararka.

1. Probiotics/Prebiotics: Kaabista noocyo gaar ah oo bakteeriya ah (tusaale, Lactobacillus, Bifidobacterium) waxay wanaajisaa shaqada xannibaadda mindhicirka.
2. Daawaynta ka hortagga bararka: daawooyinka bartilmaameedsada caabuqa mindhicirka (tusaale, TLR4 inhibitors) waxay hoos u dhigi karaan horumarka AD.
3. Waxqabadyada hab-nololeedka: jimicsiga iyo dhimista cadaadiska ayaa laga yaabaa inay ilaaliso dheelitirka flora mindhicirka

5. Gabagabada iyo Aragtida Mustaqbalka

Caabuqa mindhicirku wuxuu kordhiyaa da'da waxaana laga yaabaa inuu gacan ka geysto pathology AD iyada oo loo marayo dhidibka mindhicirka-maskaxda. Daraasadaha mustaqbalka waa in ay sii caddeeyaan xiriirka sababa ee ka dhexeeya flora gaarka ah iyo AD oo ay sahamiyaan ka hortagga AD iyo xeeladaha daawaynta ee ku salaysan nidaamka flora mindhicirka. Cilmi-baarista aaggan ayaa laga yaabaa inay bixiso bartilmaameedyo cusub oo loogu talagalay faragelinta hore ee cudurrada neurodegenerative.

Xiamen Baysen Medical Anaga Baysen Medical had iyo jeer waxay diiradda saaraan farsamada ogaanshaha si loo hagaajiyo tayada nolosha . Waxaan sameynay 5 aaladood oo tignoolajiyadeed - Latex, dahab kolloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay. Waxaan diiradda saareynaa caafimaadka mindhicirka, iyo annagaImtixaanka CAL waxaa loo isticmaalaa in lagu ogaado bararka mindhicirka.

Tixraacyo

1. Vogt, NM, iyo al. (2017). "Isbeddellada microbiome ee mindhicirka ee cudurka Alzheimers."Warbixinno Cilmiyeed.
2. Dodiya, HB, iyo al. (2020). "Bararka mindhicirka raaga ayaa ka sii daraya tau pathology ee qaabka jiirka ee cudurka Alzheimers."Dabeecadda Neuroscience.
3. Franceschi, C., iyo al. (2018). "Barar: aragti cusub oo difaac-dheecaan ah oo loogu talagalay cudurrada da'da la xiriira."Dib u eegista Dabeecadda Endocrinology.