Xiriirka ka dhexeeya Beerka Dufanka leh iyo Insulin

Xiriirka ka dhexeeya Beerka Dufanka leh iyo Insulin-ta Glyced waa xiriir dhow oo u dhexeeya beerka dufanka leh (gaar ahaan cudurka beerka dufanka leh ee aan khamriga ahayn, NAFLD) iyoinsulin(amainsuliniska caabinta, hyperinsulinemia), kaas oo inta badan lagu dhexdhexaadiyo dhibaatooyinka dheef-shiid kiimikaadka (tusaale ahaan, cayilka, nooca 2aad)macaanka,iwm.). Kuwa soo socdaa waa falanqayn faahfaahsan oo ku saabsan qodobbada muhiimka ah:

1. InsulinIska caabinta oo ah Habka Aasaasiga ah

• Insuliniska caabinta (IR) waa saldhig cudur oo caadi ah oo loogu talagalay beerka dufanka leh iyo dheef-shiid kiimikaadka gulukooska ee aan caadiga ahayn. Marka xasaasiyadda jidhku u leedahay insulin-ta ay hoos u dhacdo, ganaca ayaa si magdhow ah u soo daaya wax badan.insulin(hyperinsulinemia), taasoo keenta heerarka insulinta dhiigga oo kordha.
• Cawaaqibta beerka dufanka leh: beerkainsuliniska caabintu waxay joojisaa oksaydhka asiidhka dufanka leh, waxay kor u qaaddaa isku-darka dufanka (dhigista dufanka), waxayna sii xumeysaa ururinta dufanka ee hepatocytes (steatosis).
• Ururka lala leeyahayHbA1cInsulin-ta glycated-ka ah (glucose) ma aha calaamad caafimaad oo si caadi ah loo isticmaalo, laakiin hyperglycemia-ga daba dheeraaday (oo ku xiran IR) wuxuu kordhiyaa hemoglobin-ka glycated-ka ah.(HbA1c), oo ka tarjumaysa xakamaynta sonkorta dhiigga oo liidata, taas oo la xiriirta horumarka beerka dufanka leh ee u gudba steatohepatitis-ka aan khamriga ahayn (NASH).

2. Hyperinsulinemia waxay kor u qaaddaa Cudurka Beerka Dufanka leh

• Ficil toos ah: Hyperinsulinemia waxay kor u qaadaa lipogenesis-ka beerka (↑ isku-darka lipid) iyada oo loo marayo kicinta arrimaha qoraalka (tusaale ahaan SREBP-1c) iyadoo la joojinayo β-oxidation-ka asiidhka dufanka leh.
• Saamaynta aan tooska ahayn:Insuliniska caabintu waxay sababtaa in unugyada dufanka leh ay sii daayaan asiidhyo dufan oo bilaash ah (FFAs), kuwaas oo gala beerka oo isu beddela triglycerides, taasoo sii xumaynaysa beerka dufanka leh.

3. Beerka Dufanka leh wuxuu sii xumeeyaa dheef-shiid kiimikaadka gulukooska ee aan caadiga ahayn

• Beerka oo uu ku dhacayInsulinIska caabbinta: Beerka dufanka leh wuxuu sii daayaa cytokines bararsan (tusaale ahaan, TNF-α,IL-6) iyo adipokines (tusaale ahaan, iska caabbinta leptin, hoos u dhaca adiponectin), oo ka sii daraya iska caabbinta insulin-ta nidaamsan.
• Kordhinta gulukooska beerka:insuliniska caabintu waxay keentaa awood la'aanta beerka inuu si sax ah u joojiyo glycogenogenesis-ka, iyo gulukooska dhiigga oo sooman oo kordha ayaa sii xumeeya dheef-shiid kiimikaadka gulukooska (horumar suurtagal ah oo ku yimaada nooca 2aad ee sonkorowga).

4. Caddeynta Caafimaadka:Hemoglobin Glycosylated (HbA1c)iyo Beerka Dufanka leh

• HbA1c oo sareeya ayaa saadaaliyay khatarta beerka dufanka leh: dhowr daraasadood ayaa muujiyay inHbA1cHeerarka si togan ayaa loola xiriiriyaa darnaanta beerka dufanka leh, xitaa marka shuruudaha ogaanshaha cudurka macaanka aan la buuxin (khatarta si weyn ayay u kordheysaa marka HbA1c ≥ 5.7%).
• Xakamaynta Glycemic ee Bukaannada Beerka Dufanka leh: Bukaannada macaanka qaba ee beerka dufanka leh waxay u baahan karaan maareyn adag oo sonkorta dhiigga ah (bartilmaameedyada HbA1c ee hooseeya) si loo yareeyo horumarka cudurka beerka.

5. Istaraatiijiyadaha Faragelinta: HagaajintaInsulinXasaasiyadda

• Wax ka beddelka qaab nololeedka: miisaanka oo yaraada (5-10% miisaanka oo yaraada ayaa si weyn u hagaajiya beerka dufanka leh), cunto karbohaydrayt yar/dufan yar, jimicsi aerobic ah.
• Daawooyinka:
  • InsulinsEnsitizers (tusaale ahaan, metformin, pioglitazone) waxay hagaajin karaan dheef-shiid kiimikaadka beerka dufanka leh iyo gulukooska.
  • Daawooyinka GLP-1 ee loo yaqaan 'receptor agonists' (tusaale ahaan, liraglutide, semaglutide) waxay gacan ka geystaan ​​​​luminta miisaanka, xakamaynta glycemic-ka, iyo yareynta dufanka beerka.
• La socodka: Soonkainsulin, HOMA-IR (tusmada iska caabbinta insulin), HbA1c iyo sawirka/elastography beerka ayaa si joogto ah loo baaray.

Gunaanad

Beerka dufanka leh iyo insulin (ama hyperinsulinemia) waxay sameeyaan wareeg xun iyada oo loo marayo iska caabbinta insulinta.insuliniska caabintu waxay wanaajisaa dheef-shiid kiimikaadka beerka dufanka leh iyo gulukooska labadaba waxayna yareysaa khatarta sonkorowga iyo fibrosis-ka beerka. Calaamadaha dheef-shiid kiimikaadka waa in si wadajir ah loogu qiimeeyaa rugta caafimaadka halkii laga diiradda saari lahaa hal tilmaame oo keliya.

Annaga Baysen Medical had iyo jeer waxaan diiradda saarnaa farsamada ogaanshaha si aan u horumarinno tayada nolosha. Waxaan soo saarnay 5 goobood oo tignoolajiyadeed - Latex, dahab colloidal ah, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, OurBaaritaanka HbA1c,Baaritaanka insulintaiyoBaaritaanka C-peptide qalliin fudud oo natiijada baaritaanka lagu heli karo 15 daqiiqo gudahood