Xiriirka ka dhexeeya Beerka Dufanka leh iyo Insulin

Xiriirka ka dhexeeya Beerka Dufanka leh iyo Insulin Glycated waa xiriir dhow oo ka dhexeeya beerka dufanka leh (gaar ahaan cudurka beerka dufanka leh ee aan khamriga ahayn, NAFLD) iyoinsulin(amainsuliniska caabin, hyperinsulinemia), kaas oo lagu dhexdhexaadiyo ugu horrayn iyada oo loo marayo cilladaha dheef-shiid kiimikaadka (tusaale, buurnaanta, nooca 2sonkorowga,iwm.). Kuwa soo socda waa falanqayn faahfaahsan oo ku saabsan qodobbada muhiimka ah:

1. InsulinIska caabinta sida Farsamada Muhiimka ah

• Insuliniska caabin (IR) waa aasaaska cudurada caadiga ah ee beerka dufanka leh iyo dheef-shiid kiimikaadka gulukooska ee aan caadiga ahayn. Marka dareenka jidhku u yeesho insulinta ay yaraato, xameetidu si magdhow ah ayay u siidaayainsulinhyperinsulinemia (hyperinsulinemia), taasoo keentay in heerarka insulinta dhiigga oo sarreeya.
• Cawaaqibta beerka dufanka leh: cagaarshowinsuliniska caabintu waxay joojisaa oksaydheynta aashitada dufanka leh, waxay kor u qaadaa isku-dhafka dufanka (dhigista dufanka), waxayna ka sii daraysaa isku-ururinta dufanka ee hepatocytes (steatosis).
• Ururka lehHbA1cIn kasta oo insuliinka glycated aanu ahayn calaamad caadi ah oo la isticmaalo, hyperglycemia oo daba dheeraada (oo ku xidhan IR) waxay kordhisaa hemoglobin glycated.(HbA1c), oo ka tarjumaysa xakamaynta sonkorta dhiigga oo liidata, taas oo la xidhiidha horumarka beerka dufanka leh ee steatohepatitis (NASH).

2. Hyperinsulinemia waxay kor u qaadaa Cudurada Beerka ee Dufanka leh

• Ficilka tooska ah: Hyperinsulinemia waxay kor u qaadaa lipogenesis hepatic (↑ lipid synthesis) iyada oo loo marayo firfircoonida qodobbada qoraalka (tusaale SREBP-1c) iyadoo la xakameynayo β-oxidation dufanka leh.
• Saamaynta Dadban:Insuliniska caabintu waxay keentaa nudaha adipose si ay u sii daayaan asiidh dufan badan oo bilaash ah (FFAs), kuwaas oo gala beerka oo loo beddelo triglycerides, taas oo sii xumaynaysa beerka dufanka leh.

3. Beerka dufanku wuxuu ka sii daraa dheef-shiid kiimikaadka gulukooska ee aan caadiga ahayn

• Beerka oo uu keenoInsulinIska caabin: Beerka dufanku wuxuu sii daayaa cytokines bararka (tusaale, TNF-α,IL-6) iyo adipokines (tusaale, iska caabbinta leptin, adiponectin oo hoos u dhacday), caabbinta insulinta habaysan ee sii xumaanaysa.
• Soosaarka gulukooska beerka oo kordhay:insuliniska caabintu waxay keentaa in beerka aanu si sax ah u joojin karin gluconeogenesis, iyo gulukoosta dhiigga ee soonka oo kor u kacda waxay sii xumaynaysaa dheef-shiid kiimikaadka gulukooska (horumar suurtagal ah oo loo maro nooca 2aad ee sonkorowga).

4. Caddaynta Caafimaad:Hemoglobin Glycosylated (HbA1c)iyo Beerka Dufanka leh

• Sare u kaca HbA1c wuxuu saadaaliyaa khatarta beerka dufanka leh: daraasado dhowr ah ayaa muujiyay taasHbA1cHeerarka waxay si togan ula xiriiraan darnaanta beerka dufanka leh, xitaa marka shuruudaha lagu ogaanayo cudurka macaanka aan la buuxin (khatarta ayaa si weyn u kordhay HbA1c ≥ 5.7%).
• Xakamaynta Glycemic ee Bukaannada Beerka Dufanka leh: Bukaannada macaanka qaba ee leh beerka dufanka leh waxa laga yaabaa inay u baahdaan maaraynta sonkorta dhiigga oo adag (bartilmaameedyada HbA1c hoose) si loo yareeyo horumarka cudurka beerka.

5. Xeeladaha Faragelinta: HagaajintaInsulinDareenka

• Wax ka beddelka hab-nololeedka: miisaanka oo yaraada (5-10% miisaanka oo yaraada ayaa si weyn u wanaajiya beerka dufanka leh), cunto karbohaydrayt yar/dufan yar, jimicsi aerobic.
• Daawooyinka
  • Insulinskiciyayaasha (tusaale, metformin, pioglitazone) waxa laga yaabaa inay wanaajiyaan beerka dufanka leh iyo dheef-shiid kiimikaadka gulukooska.
  • GLP-1 agonists reseptor (tusaale, liraglutide, semaglutide) waxay caawisaa miisaanka dhimista, xakamaynta glycemic, iyo dhimista beerka dufanka leh.
• Kormeerka: Soonkainsulin, HOMA-IR (tusaha iska caabbinta insulin), HbA1c iyo sawirka beerka / lastography ayaa si joogto ah loo tijaabiyey.

Gabagabo

Beerka dufan iyo insulin (ama hyperinsulinemia) waxay sameeyaan wareeg xun iyada oo loo marayo iska caabbinta insulin. Faragelinta hore eeinsuliniska caabintu waxay wanaajisaa beerka dufanka leh iyo dheef-shiid kiimikaadka gulukooska labadaba waxayna yaraynaysaa halista cudurka macaanka iyo fibrosis beerka. Calaamadaha dheef-shiid kiimikaadka waxay u baahan yihiin in si wadajir ah loogu qiimeeyo rugta caafimaadka halkii diiradda la saari lahaa hal tilmaame oo keliya.

Annaga Baysen Medical had iyo jeer waxay diiradda saartaa farsamada ogaanshaha si loo hagaajiyo tayada nolosha . Waxaan soo saarnay 5 aaladood oo tignoolajiyadeed - Latex, dahab kolloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, OurBaaritaanka HbA1c,Baaritaanka insulintaiyoBaaritaanka C-peptide qalliin fudud oo waxay ku heli kartaa natiijada baaritaanka 15 daqiiqo