Kamano Pakeng Tsa Mafura a Sebete le Insulin

Kamano Pakeng Tsa Mafura a Sebete le Insulin ea Glycated ke kamano e haufi pakeng tsa sebete se mafura (haholo-holo lefu la sebete le se nang joala, NAFLD) leinsulin(kapainsulinho hanyetsa, hyperinsulinemia), e kenellang haholo-holo ka mathata a metabolism (mohlala, botenya, mofuta oa 2).lefu la tsoekere,joalo-joalo). E latelang ke tlhahlobo e qaqileng ea lintlha tsa bohlokoa:

1. InsulinKhanyetso e le Mokhoa oa Motheo

• Insulinresistance (IR) ke motheo o tloaelehileng oa pathological bakeng sa sebete se mafura le metabolism e sa tloaelehang ea tsoekere. Ha kutloisiso ea 'mele ho insulin e fokotseha, manyeme a hlahisa ho fetainsulinhyperinsulinemia (hyperinsulinemia), e bakang maemo a phahameng a insulin maling.
• Liphello tsa sebete se mafura: sebeteinsulinho hanyetsa ho thibela mafura a acid oxidation, ho khothalletsa motsoako oa mafura (lipid deposition), 'me ho mpefatsa ho bokellana ha mafura ho hepatocytes (steatosis).
• Kopanya leHbA1cLe hoja insulin ea glycated e se letšoao le sebelisoang hangata, hyperglycemia ea nako e telele (e amahanngoa le IR) e eketsa hemoglobin ea glycated.(HbA1c), e bontšang taolo e fokolang ea tsoekere e maling, e amanang le tsoelo-pele ea sebete sa mafura ho steatohepatitis e seng joala (NASH).

2. Hyperinsulinemia e Khothalletsa Mafura a Sebete sa Mafura

• Ketso e tobileng: Hyperinsulinemia e khothaletsa hepatic lipogenesis (↑ lipid synthesis) ka ho kenya tšebetsong lintlha tsa transcription (mohlala, SREBP-1c) ha e ntse e thibela mafura a acid β-oxidation.
• Tšusumetso e sa Tobang:Insulinho hanyetsa ho etsa hore lisele tsa adipose li lokolle mafura a mangata a mahala (FFAs), a kenang sebeteng ebe a fetoloa triglycerides, 'me sebete se ntse se mpefala le ho feta.

3. Sebete sa Mafura se Eketsa metabolism ea glucose e sa tloaelehang

• E bakoang ke SebeteInsulinKhanyetso: Sebete se mafura se ntša li-cytokine tse ruruhileng (mohlala, TNF-α,IL-6) le li-adipokine (mohlala, ho hanyetsa leptin, ho fokotseha ha adiponectin), ho mpefatsa tsamaiso ea insulin ho hanyetsa.
• Keketseho ea tsoekere ea hepatic: +insulinHo hanyetsa ho fella ka ho sitoa ha sebete ho thibela gluconeogenesis hantle, 'me ho phahama ha tsoekere ea mali ho mpefatsa metabolism ea tsoekere (ts'ebetso e ka bang teng ho lefu la tsoekere la mofuta oa 2).

4. Bopaki ba Clinical:Glycosylated Hemoglobin (HbA1c)le Fatty Liver

• HbA1c e phahameng e bolela esale pele kotsi ea sebete sa mafura: lithuto tse 'maloa li bontšitse seoHbA1cmaemo a amana hantle le ho teba ha sebete sa mafura, le ha mekhoa ea tlhahlobo ea lefu la tsoekere e sa fihlelle (kotsi e eketseha haholo ka HbA1c ≥ 5.7%).
• Taolo ea Glycemic ho Bakuli ba Sebete ba Mafura: Bakuli ba lefu la tsoekere ba nang le sebete se mafura ba ka hloka taolo e thata ea tsoekere ea mali (lipheo tse tlase tsa HbA1c) ho liehisa tsoelo-pele ea lefu la sebete.

5. Merero ea ho kenella: Ho ntlafatsaInsulinKutloisiso

• Liphetoho tsa mokhoa oa bophelo: ho theola boima ba 'mele (5-10% ho theola boima ba 'mele haholo ho ntlafatsa sebete sa mafura), lijo tse tlaase tsa lik'habohaedreite / mafura a tlaase, boikoetliso ba aerobic.
• Meriana:
  • Isulinsli-ensitizers (mohlala, metformin, pioglitazone) li ka ntlafatsa sebete sa mafura le metabolism ea tsoekere.
  • Li-agonists tsa GLP-1 (mohlala, liraglutide, semaglutide) li thusa ho theola boima ba 'mele, taolo ea glycemic, le phokotso ea sebete sa mafura.
• Tlhokomelo: Ho itima lijoinsulin, HOMA-IR (insulin resistance index), HbA1c le sebete imaging/elastography li ne li lekoa khafetsa.

Qetello

Sebete se mafura le insulin (kapa hyperinsulinemia) theha potoloho e mpe ka ho hanyetsa insulin. Ho kenella pele ho nako eainsulinho hanyetsa ho ntlafatsa sebete sa mafura le metabolism ea tsoekere le ho fokotsa kotsi ea lefu la tsoekere le sebete sa fibrosis. Matšoao a metabolism a hloka ho hlahlojoa hammoho tleliniking ho fapana le ho shebana le letšoao le le leng feela.

We Baysen Medical re lula re tsepamisitse maikutlo holima mokhoa oa ho hlahloba ho ntlafatsa boleng ba bophelo. Re thehile li-platform tse 5 tsa theknoloji- Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular,Chemiluminescence Immunoassay, OurTlhahlobo ea HbA1c,Teko ea insulinleTeko ea C-peptide ts'ebetso e bonolo mme e ka fumana sephetho sa tlhahlobo ka mor'a metsotso e 15