Kamano Pakeng tsa Sebete se Mafura le Insulin

Kamano Pakeng tsa Sebete se Mafura le Glycated Insulin ke kamano e haufi pakeng tsa sebete se mafura (haholo-holo lefu la sebete se mafura se seng joala, NAFLD) leinsulin(kapainsulinho hanyetsa, hyperinsulinemia), e bakoang haholo-holo ke mathata a metabolism (mohlala, botenya, mofuta oa 2lefu la tsoekere,jj.). Se latelang ke tlhahlobo e qaqileng ea lintlha tsa bohlokoa:

1. InsulinKhanyetso e le Mokhoa oa Bohlokoa

• Insulinkhanyetso (IR) ke motheo o tloaelehileng oa pathological bakeng sa mafura a sebete le metabolism e sa tloaelehang ea tsoekere. Ha kutloisiso ea 'mele ho insulin e fokotseha, manyeme a ntša metsi a mangata ka mokhoa o lefelloang.insulin(hyperinsulinemia), e leng se fellang ka maemo a phahameng a insulin maling.
• Litlamorao tsa sebete se mafura: sebeteinsulinHo hanyetsa ho thibela ho oxidation ea mafura a mafura, ho khothalletsa tlhahiso ea mafura (ho boloka mafura), 'me ho mpefatsa ho bokellana ha mafura ka har'a li-hepatocytes (steatosis).
• Kamano leHbA1cLeha insulin e nang le glycated e se letšoao le sebelisoang haholo la bongaka, hyperglycemia e telele (e amanang le IR) e eketsa hemoglobin e nang le glycated(HbA1c), e bontshang taolo e fokolang ya tswekere mading, e amanang le ho tswela pele ha sebete se mafura ho ya ho steatohepatitis e seng ya jwala (NASH).

2. Hyperinsulinemia e Khothalletsa Mafu a Sebete se Mafura

• Ketso e tobileng: Hyperinsulinemia e khothalletsa lipogenesis ea sebete (↑ lipid synthesis) ka ho kenya tšebetsong lintlha tsa transcription (mohlala, SREBP-1c) ha ka nako e ts'oanang e thibela mafura a acid β-oxidation.
• Phello e sa tobang:InsulinHo hanyetsa ho etsa hore lisele tsa mafura li lokolle mafura a mangata a mahala (FFAs), a kenang sebeteng 'me a fetoloa triglycerides, e leng se mpefatsang sebete se mafura le ho feta.

3. Sebete se Mafura se eketsa metabolism e sa tloaelehang ea tsoekere

• Ho Hlohlelletsoa ke SebeteInsulinHo hanyetsa: Sebete se mafura se ntša li-cytokine tse ruruhang (mohlala, TNF-α,IL-6) le li-adipokine (mohlala, ho hanyetsa leptin, ho fokotseha ha adiponectin), ho mpefatsa ho hanyetsa insulin 'meleng.
• Keketseho ea tlhahiso ea glucose sebeteng:insulinHo hanyetsa ho fella ka ho hloleha ha sebete ho thibela gluconeogenesis ka nepo, 'me tsoekere e phahameng maling e itimang e mpefatsa metabolism ea glucose le ho feta (ho ka etsahala hore e be lefu la tsoekere la mofuta oa 2).

4. Bopaki ba Bongaka:Hemoglobin e nang le Glycosylated (HbA1c)le Sebete se Mafura

• HbA1c e phahameng e bolela esale pele kotsi ea sebete se mafura: lithuto tse 'maloa li bontšitse horeHbA1cMaemo a amana hantle le boima ba sebete se mafura, esita le ha litekanyetso tsa tlhahlobo ea lefu la tsoekere li sa fihlelloe (kotsi e eketseha haholo ka HbA1c ≥ 5.7%).
• Taolo ea Glycemic ho Bakuli ba Sebete se Mafura: Bakuli ba nang le lefu la tsoekere ba nang le sebete se mafura ba ka hloka taolo e thata ea tsoekere maling (lipheo tse tlase tsa HbA1c) ho liehisa tsoelo-pele ea lefu la sebete.

5. Maano a ho Kena: NtlafatsoInsulinHo ba le kutloelo-bohloko

• Liphetoho tsa mokhoa oa bophelo: ho theola boima ba 'mele (ho theola boima ba 'mele ka 5-10% ho ntlafatsa sebete se mafura haholo), lijo tse nang le lik'habohaedreite tse tlase/mafura a tlase, boikoetliso ba aerobic.
• Meriana:
  • IinsulinsLi-ensitizer (mohlala, metformin, pioglitazone) li ka ntlafatsa metabolism ea mafura sebeteng le tsoekere.
  • Li-agonist tsa li-receptor tsa GLP-1 (mohlala, liraglutide, semaglutide) li thusa ho theola boima ba 'mele, ho laola glycemia le ho fokotsa mafura sebeteng.
• Tlhokomelo: Ho Itima Lijoinsulin, HOMA-IR (insulin resistance index), HbA1c le ho nka ditshwantsho tsa sebete/elastography di ne di lekoa kgafetsa.

Qetello

Sebete se mafura le insulin (kapa hyperinsulinemia) e etsa potoloho e mpe ka lebaka la ho hanyetsa insulin. Ho kenella kapele ha insulininsulinHo hanyetsa ho ntlafatsa metabolism ea mafura sebeteng le tsoekere 'me ho fokotsa kotsi ea lefu la tsoekere le fibrosis ea sebete. Matšoao a metabolism a hloka ho hlahlojoa hammoho kliniking ho e-na le ho tsepamisa maikutlo ho sesupo se le seng feela.

Re Baysen Medical re lula re tsepamisitse maikutlo mokhoeng oa ho hlahloba ho ntlafatsa boleng ba bophelo. Re thehile li-platform tse 5 tsa theknoloji - Latex, colloidal gold, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, OurTeko ea HbA1c,Teko ea insulinleTeko ea C-peptide tshebetso e bonolo mme e ka fumana sephetho sa teko ka metsotso e 15