Intshayelelo: Ukubaluleka kweKlinikhi yokuHlolwa kokuSebenza kweZintso kwaKwangoko:

Isifo sezintso esinganyangekiyo (Chronic kidney disease) (CKD) sibe ngumngeni kwimpilo yoluntu jikelele. Ngokwezibalo ezivela kuMbutho wezeMpilo weHlabathi, malunga ne-850 yezigidi zabantu kwihlabathi jikelele baphathwa zizifo zezintso ezahlukeneyo, kwaye ukuxhaphaka kwezifo ezingapheliyo zesifo malunga ne-9.1%. Okubaluleke ngakumbi kukuba isifo sezintso ezingapheliyo zihlala zingenazo iimpawu ezicacileyo, ezibangela ukuba inani elikhulu lezigulana ziphuthe ixesha elifanelekileyo lokungenelela. Ngokuchasene nale mvelaphi,microalbuminuria, njengesalathiso esibuthathaka somonakalo wezintso zakuqala, uye wabaluleka kakhulu. Iindlela eziqhelekileyo zokuvavanya umsebenzi wezintso ezifana ne-serum creatinine kunye noqikelelo lwe-glomerular filtration rate (eGFR) ziya kubonisa kuphela izinto ezingaqhelekanga xa umsebenzi wezintso ulahlekile ngaphezu kwe-50%, ngelixa uvavanyo lwe-albumin yomchamo lunokubonelela ngezibonakaliso zesilumkiso kwangethuba xa umsebenzi wezintso ulahlekile nge-10-15%.

Ixabiso leklinikhi kunye nesimo sangoku seI-ALBuvavanyo lomchamo

Ialbhamin (ALB) iprotheni eninzi kakhulu kumchamo wabantu abanempilo, kunye nesantya esiqhelekileyo sokukhupha ngaphantsi kwe-30mg / 24h. Xa i-albhamuin ye-urinary excretion iphakathi kwe-30-300mg / 24h, ichazwa njenge-microalbuminuria, kwaye eli nqanaba liyifestile yegolide yokungenelela ukubuyisela umonakalo wezintso. Okwangoku, ezisetyenziswa ngokuqhelekileyoI-ALBiindlela zokufumanisa kwiinkqubo zeklinikhi ziquka i-radioimmunoassay, i-enzyme-linked immunosorbent assay (ELISA), i-immunoturbidimetry, njl., Kodwa ezi ndlela ngokubanzi zineengxaki ezifana nokusebenza okunzima, ukusetyenziswa kwexesha elide, okanye imfuno yezixhobo ezizodwa. Ngokukodwa kumaziko onyango aphambili kunye neemeko zokubeka iliso ekhaya, itekhnoloji esele ikhona kunzima ukuhlangabezana neemfuno zokulula, isantya, kunye nokuchaneka, okukhokelela kwinani elikhulu lezigulana ezinomonakalo wezintso kwangoko zingafunyanwanga ngexesha.

Ukuphumelela okutsha kwi-PrecisionUvavanyo lwe-ALB UmchamoI-Reagent

Ukuphendula imida yetekhnoloji yovavanyo ekhoyo, inkampani yethu iphuhlise i-PrecisionUvavanyo lwe-ALB Umchamo I-Reagent yokuqonda inani leempumelelo zetekhnoloji. I-reagent ithatha iteknoloji ye-immunochromatographic ephezulu kunye nobudlelwane obuphezulu kunye ne-anti-human albumin monoclonal antibody ukuqinisekisa ukuchaneka kunye nokuthembeka kovavanyo. Ubuchule obutsha bubonakaliswa ikakhulu kwimiba emithathu:

• Ubuzwe obuphuculwe ngokuphawulekayo: umda ophantsi wokufumanisa ufikelela kwi-2mg / L, kwaye unako ukuqaphela ngokuchanekileyo umda we-urinary we-microalbumin we-30mg / 24h, ongcono kakhulu kunovakalelo lwemicu yovavanyo lwendabuko.
• Ukomelezwa kwesakhono sokuchasana nokuphazamiseka: Ngoyilo lwenkqubo ye-buffer ekhethekileyo, inokoyisa ngempumelelo uphazamiseko lokuguquguquka kwe-pH yomchamo, utshintsho lwamandla e-ionic kunye nezinye izinto kwiziphumo zovavanyo, iqinisekisa uzinzo lovavanyo phantsi kweemeko ezahlukeneyo zomzimba.
• Ukufumanisa ubungakanani obutsha: umfundi okhethekileyo oxhasayo unokuqonda ubungakanani be-semi-quantitative ukufumanisa ubungakanani, uluhlu lokufumanisa lugubungela i-0-200mg / L, ukuhlangabezana neemfuno ezahlukeneyo zeklinikhi ukusuka ekuhlolweni ukuya ekubekweni iliso.

Ukusebenza kweMveliso kunye nezinto eziluncedo

Iqinisekiswe ngokweklinikhi kwizibhedlele ezininzi eziphakamileyo, le reagent ibonisa izikhombisi zokusebenza ezigqwesileyo. Xa kuthelekiswa nomgangatho wegolide weyure ezingama-24 ubungakanani be-albumin yomchamo, i-coefficient yokulungelelanisa ifikelela ngaphezu kwe-0.98; i-intra- kunye ne-inter-batch coefficients yokwahluka ingaphantsi kwe-5%, iphantsi kakhulu kunomgangatho woshishino; ixesha lokufumanisa yimizuzu eyi-15 kuphela, ephucula kakhulu ukusebenza kakuhle kweklinikhi. Iinzuzo zemveliso zishwankathelwa ngezantsi:

• Ukulula kokusebenza: akukho mfuneko yonyango olunzima lwangaphambili, iisampulu zomchamo zinokuba ngokuthe ngqo kwisampulu, umsebenzi onamanyathelo amathathu ukugqiba uvavanyo, abangengabo abachwephesha banokwazi emva koqeqesho olufutshane.
• Iziphumo ezinengqondo: ukusetyenziswa kwenkqubo yophuhliso lombala ocacileyo, iliso lenyama linokufundwa ekuqaleni, amakhadi ombala ahambelanayo anokuba luhlalutyo lwe-semi-quantitative, ukuhlangabezana neemfuno zeemeko ezahlukeneyo zesicelo.
• Uqoqosho kunye nokusebenza kakuhle: ixabiso lovavanyo olulodwa liphantsi kakhulu kunelo vavanyo lwebhubhoratri, olulungele ukuhlolwa okukhulu kunye nokubeka iliso ixesha elide, kwaye inexabiso elibalaseleyo loqoqosho lwezempilo.

• Ixabiso lesilumkiso kwangethuba: umonakalo wezintso unokubonwa kwiminyaka eyi-3-5 ngaphambili kunezalathisi zesiqhelo zokusebenza kwezintso, ukuphumelela ixesha elixabisekileyo lokungenelela kwezonyango.

Iimeko zesicelo seklinikhi kunye neengcebiso zesikhokelo

UkuchanekaALB Umchamo Testinoluhlu olubanzi lweemeko zesicelo. Kwintsimi yesifo seswekile, izikhokelo ze-American Diabetes Association (ADA) zincoma ngokucacileyo ukuba zonke izigulane ezinesifo sikashukela sohlobo loku-1 ≥ iminyaka emi-5 kunye nazo zonke izigulane ezinesifo sikashukela sohlobo lwe-2 kufuneka zenze uvavanyo lwe-albhamuin yomchamo ngonyaka. Kulawulo lwe-hypertension, izikhokelo ze-ESC / ESH zoxinzelelo lwegazi ziluhlu lwe-microalbuminuria njengophawu olubalulekileyo lomonakalo ojoliswe kuwo. Ukongeza, i-reagent ifanelekile kwiimeko ezininzi ezifana novavanyo lwengozi yesifo senhliziyo, ukuhlolwa komsebenzi wezintso kubantu abadala, kunye nokujongwa kweentso ngexesha lokukhulelwa.

Eyona nto inomdla kukuba le mveliso ihambelana ngokugqibeleleyo neemfuno zokuxilongwa kwe-hierarchical kunye nonyango. Ingasetyenziswa njengesixhobo esisebenzayo sokuhlola isifo sezintso kumaziko onyango asisiseko afana nezibhedlele zoluntu kunye namaziko ezempilo asezilokishini; kumasebe e-nephrology kunye ne-endocrinology kwizibhedlele eziqhelekileyo, ingasetyenziselwa njengesixhobo esibalulekileyo sokulawula izifo kunye nokubeka iliso ngempumelelo; kumaziko okuhlolwa kwezonyango, inokufakwa kwiiphakheji zokuhlola impilo ukwandisa izinga lokubona ukwenzakala kwezintso kwangoko; kwaye ilindeleke ukuba ingene kwimarike yokubeka iliso kwimpilo yosapho emva kokuqinisekiswa ngakumbi kwixesha elizayo.

Ukuqukumbela

Thina iBaysen Medical sihlala sigxile kwindlela yokuxilonga ukuphucula umgangatho wobomi. Siphuhlise amaqonga obuchwepheshe ama-5- iLatex, igolide ye-colloidal, iFluorescence Immunochromatographic Assay, iMolekyuli, iChemiluminescence Immunoassay.SinayoUvavanyo lwe-ALB FIA ukuJonga ukwenzakala kwezintso kwinqanaba lakwangoko