Intshayelelo: Ukubaluleka kweKlinikhi kokuBekwa kweliso kwangethuba kweMisebenzi yezintso:

Isifo sezintso esinganyangekiyo (CKD) sibe ngumceli mngeni wezempilo yoluntu kwihlabathi liphela. Ngokwezibalo ezivela kwi-World Health Organisation, malunga nezigidi ezingama-850 zabantu kwihlabathi liphela bahlushwa zizifo ezahlukeneyo zezintso, kwaye ukuxhaphaka kwesifo sezintso esinganyangekiyo kwihlabathi liphela kumalunga ne-9.1%. Okubi kakhulu kukuba isifo sezintso esinganyangekiyo sasekuqaleni sidla ngokungabonisi zimpawu zicacileyo, nto leyo ebangela ukuba inani elikhulu lezigulana liphoswe lixesha elifanelekileyo lokungenelela. Ngaphandle kwesi sizathu,i-microalbuminuria, njengesibonakaliso esibuthathaka somonakalo wezintso kwangethuba, iye yaba luncedo kakhulu. Iindlela zovavanyo lomsebenzi wezintso zemveli ezifana ne-serum creatinine kunye ne-estimated glomerular filtration rate (eGFR) ziya kubonisa kuphela ukungaqheleki xa umsebenzi wezintso ulahlekile ngaphezulu kwama-50%, ngelixa uvavanyo lwe-urine albumin lunokubonelela ngemiqondiso yesilumkiso kwangethuba xa umsebenzi wezintso ulahlekile nge-10-15%.

Ixabiso leklinikhi kunye nemeko yangoku yeI-ALBuvavanyo lomchamo

I-Albumin (i-ALB) yeyona protein ininzi kakhulu kumchamo kubantu abasempilweni, kunye nesantya esiqhelekileyo sokukhupha i-albumin yomchamo esingaphantsi kwe-30mg/24h. Xa izinga lokukhupha i-albumin kumchamo liphakathi kwe-30-300mg/24h, lichazwa njenge-microalbuminuria, kwaye eli nqanaba lixesha legolide lokungenelela ukubuyisela umva umonakalo wezintso. Okwangoku, isetyenziswa kakhuluI-ALBIindlela zokufumanisa kwiklinikhi ziquka uvavanyo lwe-radioimmunoassay, uvavanyo lwe-enzyme-linked immunosorbent assay (ELISA), i-immunoturbidimetry, njl.njl., kodwa ezi ndlela zihlala zineengxaki ezifana nokusebenza okunzima, ukusetyenziswa ixesha elide, okanye isidingo sezixhobo ezikhethekileyo. Ingakumbi kumaziko ezonyango aphambili kunye neemeko zokujonga ekhaya, ubuchwepheshe obukhoyo kunzima ukuhlangabezana neemfuno zobulula, isantya, kunye nokuchaneka, nto leyo ebangela ukuba inani elikhulu lezigulana ezinomonakalo wezintso kwangethuba zingafunyanwa ngexesha.

Uphuhliso Olutsha kwiNgcaliUvavanyo lomchamo lwe-ALBI-Reagent

Ukuphendula kwimida yetekhnoloji yokuvavanya ekhoyo, inkampani yethu iphuhlise iPrecisionUvavanyo lomchamo lwe-ALB I-Reagent ukuze ifezekise iimpumelelo ezininzi zobuchwepheshe. I-reagent isebenzisa iteknoloji ye-immunochromatographic ephucukileyo ene-affinity ephezulu kunye ne-antibody ye-albumin monoclonal ekhethekileyo ukuqinisekisa ukuchaneka nokuthembeka kovavanyo. Ubuchule obutsha bubonakala kakhulu kwiinkalo ezintathu:

• Uvakalelo oluphuculweyo kakhulu: umda ophantsi wokufunyanwa ufikelela kwi-2mg/L, kwaye iyakwazi ukubona ngokuchanekileyo umda womchamo we-microalbumin we-30mg/24h, nto leyo engcono kakhulu kunovakalelo lwee-test strips zemveli.
• Ukuphucula amandla okulwa nokuphazamiseka: Ngokusebenzisa uyilo lwenkqubo ye-buffer ekhethekileyo, inokuyinqoba ngempumelelo ukuphazamiseka kokuguquguquka kwe-pH yomchamo, utshintsho lwamandla e-ionic kunye nezinye izinto kwiziphumo zovavanyo, ukuqinisekisa uzinzo lovavanyo phantsi kweemeko ezahlukeneyo zomzimba.
• Ukuchonga ubungakanani obutsha: umfundi okhethekileyo oxhasayo unokufumanisa ukufumanisa okuphakathi kobungakanani ukuya kobuninzi, uluhlu lokufumanisa lugubungela i-0-200mg/L, ukuhlangabezana neemfuno ezahlukeneyo zeklinikhi ukusuka ekuhlolweni ukuya ekubekweni esweni.

Ukusebenza kweMveliso kunye neeNzuzo

Iqinisekiswe ngokwezonyango kwizibhedlele ezininzi ze-tertiary, le reagent ibonisa izalathisi zokusebenza ezigqwesileyo. Xa kuthelekiswa nomlinganiselo wegolide we-albumin yomchamo weeyure ezingama-24, i-coefficient yokuhambelana ifikelela ngaphezulu kwe-0.98; ii-coefficients zangaphakathi kunye ne-inter-batch zokwahluka zingaphantsi kwe-5%, ziphantsi kakhulu kunomgangatho woshishino; ixesha lokufumanisa liyimizuzu eli-15 kuphela, nto leyo ephucula kakhulu ukusebenza kakuhle kweklinikhi. Iingenelo zemveliso zishwankathelwe apha ngezantsi:

• Ukulula kokusebenza: akukho mfuneko yonyango olunzima lwangaphambi kokuba lusetyenziswe, iisampulu zomchamo zingafakwa ngqo kwisampulu, utyando olunezinyathelo ezintathu ukuze kugqitywe uvavanyo, abantu abangengoochwephesha banokukwazi ukulufunda emva koqeqesho olufutshane.
• Iziphumo eziqondakalayo: ukusetyenziswa kwenkqubo yophuhliso lombala ecacileyo, iliso lenyama linokufundwa ekuqaleni, amakhadi emibala ahambelanayo anokuba luhlalutyo oluncinci, ukuhlangabezana neemfuno zeemeko ezahlukeneyo zokusetyenziswa.
• Eyongayo nesebenzayo: ixabiso lovavanyo olunye liphantsi kakhulu kunelo lovavanyo lwelebhu, olufanele ukuvavanywa okukhulu kunye nokubekwa esweni ixesha elide, kwaye lunexabiso elibalaseleyo kwezoqoqosho kwimpilo.

• Ixabiso lesilumkiso kwangethuba: umonakalo kwizintso unokubonwa kwiminyaka emi-3-5 ngaphambi kweempawu zokusebenza kwezintso eziqhelekileyo, nto leyo enika ixesha elibalulekileyo lokungenelela kwezonyango.

Iimeko zesicelo seklinikhi kunye neengcebiso zesikhokelo

UchanekoIi-Alb Umchamo Testineendlela ezahlukeneyo zokusetyenziswa. Kwicandelo lesifo seswekile, izikhokelo ze-American Diabetes Association (ADA) zicebisa ngokucacileyo ukuba zonke izigulana ezinesifo seswekile sohlobo loku-1 ≥ iminyaka emi-5 kunye nazo zonke izigulana ezinesifo seswekile sohlobo lwesibini kufuneka zenze uvavanyo lwe-albumin yomchamo minyaka le. Kulawulo lwe-hypertension, izikhokelo ze-ESC/ESH hypertension zidwelisa i-microalbuminuria njengophawu olubalulekileyo lomonakalo wamalungu athile ekujoliswe kuwo. Ukongeza, i-reagent ifanelekile kwiimeko ezininzi ezifana novavanyo lomngcipheko wesifo sentliziyo, ukuhlolwa komsebenzi wezintso kubantu abadala, kunye nokuhlolwa kwezintso ngexesha lokukhulelwa.

Okubangela umdla kukuba le mveliso ihambelana ngokugqibeleleyo neemfuno zokuxilongwa kunye nonyango oluhambelanayo. Ingasetyenziswa njengesixhobo esisebenzayo sokuhlola isifo sezintso kumaziko ezonyango aphambili afana nezibhedlele zoluntu kunye namaziko ezempilo asezidolophini; kumasebe e-nephrology kunye ne-endocrinology kwizibhedlele eziqhelekileyo, ingasetyenziswa njengesixhobo esibalulekileyo solawulo lwesifo kunye nokujonga ngempumelelo; kumaziko okuhlolwa kwezonyango, inokufakwa kwiiphakheji zokuhlolwa kwempilo ukwandisa izinga lokufunyaniswa kokwenzakala kwezintso kwangethuba; kwaye kulindeleke ukuba ingene kwimarike yokujonga impilo yosapho emva kokuqinisekiswa ngakumbi kwixesha elizayo.

Isiphelo

I-Baysen Medical isoloko igxile kwindlela yokuxilonga ukuphucula umgangatho wobomi. Siphuhlise amaqonga etekhnoloji ama-5- iLatex, igolide ye-colloidal, uvavanyo lwe-Fluorescence Immunochromatographic, i-Molecular, i-Chemiluminescence Immunoassay.Uvavanyo lwe-ALB FIA Ukujonga ukwenzakala kwezintso kwinqanaba lokuqala