Uvavanyo Olungenalo Uhlaselo:I-Calprotectin yeNdle"Inqumla imida" ukunceda ekuxilongweni kwangethuba kokudumba kwe-Upper GI ebantwaneni

Kwicandelo lokuxilonga izifo zenkqubo yokugaya ukutya kwabantwana, i-endoscopy ibisoloko "iyindlela efanelekileyo" yokufumanisa ukudumba kwamathumbu aphezulu. Nangona kunjalo, olu vavanyo oluhlaselayo alupheleli nje ekungonwabi ngokwasemzimbeni kubantwana, ingakumbi abancinci, kodwa ludla ngokuzisa uloyiko olukhulu lwengqondo kunye nobunzima bokusebenzisana. Oku kwenza abazali abaninzi bathandabuze ngexesha lokuxilongwa kokuqala kwaye banokuphoswa lithuba lokungenelela kwangoko. Kutshanje, uphando olutsha lweklinikhi kunye noqheliselo lokusetyenziswa luzise iindaba ezimnandi:i-calprotectin yendle (i-FCP), uphawu oluvuthiweyo olungangenisi ntsholongwane lokuvavanya izifo zesisu esisezantsi, lubonisa amandla amakhulu ekuxilongweni kwangethuba kokudumba kwesisu esingaphezulu ebantwaneni, nto leyo efezekisa "indlela entsha" emangalisayo ukusuka "emathunjini asezantsi" ukuya "emathunjini aphezulu".

Ukusuka kwiNgxaki ye "Gold Standard" ukuya ekuQaleni koVavanyo oluNgenalo Uhlaselo

Ukudumba kwamathumbu okuphezulu okufana ne-gastritis kunye ne-gastroduodenitis akuqhelekanga ebantwaneni, kwaye izizathu zazo ziquka usulelo, amayeza, kunye neempendulo zoxinzelelo. Ngokwesiko, ukuxilongwa kufuna ukujongwa ngamehlo kunye ne-tissue biopsy nge-gastroscopy, inkqubo enzima nengena ngaphakathi. Iindlela zokufumanisa ezingezizo ezingena ngaphakathi nezilula bezisoloko ziyinto eqhelekileyo elindelwe ziingcali zonyango kunye neentsapho zabantwana abanesifo.I-calprotectin yendleyiproteni ebonisa ukuhlanganiswa kwe-neutrophil. Xa i-mucosa yesisu ivuvukile, uxinaniso lwayo luya kwanda kakhulu. Kwiminyaka edlulileyo, isetyenziswa kakhulu kuvavanyo lomsebenzi wesifo samathumbu esivuthayo (IBD) kunye nokuxilongwa okuhlukileyo kwe-irritable bowel syndrome (IBS), ikakhulu ekuvuvukeni kwamathumbu amakhulu.

Uphando lwezenzululwazi luqinisekisa isiseko esiqinileyo sezicelo "ezinqumla imida"

Uphando oluninzi lubonisa ukuba olu phawu lokuvuvukala alukho kwikholoni kuphela. Xa ukudumba okusebenzayo kwenzeka kwindlela ephezulu yesisu (njengesisu kunye ne-duodenum), iiseli zokuvuvukala nazo ziyangena kwaye zikhulule.i-calprotectinLe proteni ihamba kwindlela yokugaya ukutya kunye nolwelo lokugaya ukutya kunye neentsalela zokutya, ekugqibeleni zifunyanwa kwindle. Izifundo zakutshanje ebantwaneni zibonise ukubai-calprotectin yendleAmanqanaba aphezulu kakhulu kubantwana abane-gastritis okanye i-duodenitis eqinisekisiweyo nge-endoscopically xa kuthelekiswa nabo bane-dyspepsia esebenzayo okanye iziphumo eziqhelekileyo ze-endoscopic. Nangona amanqanaba aphezulu e-FC abangelwa kukudumba kwesisu okuphezulu ngokubanzi esezantsi kunalawo akwi-IBD esebenzayo, abonise umahluko obalulekileyo ngokwezibalo xa kuthelekiswa nabantu abasempilweni. Oku kuthetha ukuba uvavanyo lwe-FC lungasetyenziswa njengesixhobo sokuhlola esisebenzayo ukunceda oogqirha ekuqaleni babone abantwana abasengozini enkulu yokudumba kwesisu okungokwemvelo phakathi kwenani elikhulu labantwana ababonisa iimpawu ezifana nentlungu yesisu, ukudumba, kunye nokugabha.

Ixabiso leKliniki: Ukwakha Indlela Engcono Yokuxilonga Abantwana

Ukusetyenziswa kwemidai-calprotectin yendleizise iingenelo ezininzi ekuxilongweni nasekulawuleni izifo zesisu esingaphezulu ebantwaneni:

1. Ayingenisi ntsholongwane kwaye ithobela umthetho ophezulu: Kufuneka isampuli encinci yesitulo, kwaye le nkqubo ayingenisi ntsholongwane kwaphela, nto leyo enciphisa kakhulu umthwalo womzimba nengqondo ebantwaneni. Abazali bayayamkela kakhulu le nkqubo, nto leyo eyenza kube lula ukuqhuba ngokukhawuleza ukujonga ngokuphindaphindiweyo kwiikliniki zangaphandle.
2. Isixhobo esisebenzayo sokuhlola nokulungisa amathumbu: Kubantwana abaneempawu zesisu ezingapheliyo,I-Calprotectin yeNdleUvavanyo lungenziwa kuqala ukuze kwahlulwe ngempumelelo phakathi kwezifo ezibangelwa kukudumba kunye nezo zisebenzayo.I-calprotectin yendleamanqanaba aqhelekileyo, izinto ezisebenzayo zinokubekwa phambili okanye unyango olusekelwe kwiziphumo zovavanyo kunye nokuhlolwa kunokwamkelwa. Ukuba amanqanaba e-FC aphakanyisiwe, inika isiseko esomeleleyo se-gastroscopy ehlaselayo, iphephe iinkqubo ze-endoscopic ezingeyomfuneko kwaye iphucule ulwabiwo lwezixhobo zonyango.
3. Uvavanyo oluncediswayo lokusebenza kakuhle kunye nokubuyela kwimeko yesiqhelo: Emva kokufunyaniswa kokudumba kwamathumbu aphezulu kunye nokuqala konyango, ukubekwa esweni okunamandla kotshintsho kwiI-Calprotectin yeNdleAmanqanaba anokusebenza njengesalathiso esifanelekileyo sokuvavanya ukuba ukudumba kuye kwaphela na kwaye unyango luyasebenza na. Kunokunceda ekufumaneni ukuphinda kwesifo kwangethuba.

Imbono yexesha elizayo

Kakade ke, ukusetyenziswa kwe-calprotectin yendle kwindlela ephezulu yesisu kusafuna uphando olongezelelekileyo ukuze kuchazwe ngokuchanekileyo ixabiso layo elifanelekileyo lokuphela kunye nokuthintela ezinye izinto ezisezantsi zesisu ezinokubangela i-FC ephezulu. Nangona kunjalo, njengendlela yokuvavanya ekhuselekileyo, elula, nengabizi kakhulu, ngokungathandabuzekiyo ivula umnyango omtsha wokuxilongwa kwangoko kokudumba kwesisu okuphezulu ebantwaneni. Iphawula inyathelo eliya phambili ekuxilongweni kwezifo zokugaya ukutya kwabantwana ukuya kwindlela enobuntu nechanekileyo. Sikholelwa ukuba ngophando oluqhubekayo olunzulu kunye namava eklinikhi aqokelelweyo,i-calprotectin yendle,le "nkwenkwezi ye-crossover," iya kudlala indima ebaluleke ngakumbi ekukhuseleni impilo yokugaya ukutya kwabantwana.

I-Baysen Medical isoloko igxile kwindlela yokuxilonga ukuphucula umgangatho wobomi. Siphuhlise amaqonga obuchwephesha ama-5- iLatex, igolide ye-colloidal, uvavanyo lwe-Fluorescence Immunochromatographic, i-Molecular, i-Chemiluminescence Immunoassay. Sinegolide ye-ColloidalI-calprotectin yendle ikhithi yovavanyo kunye neFluorescence ImmunoassayIkhithi yovavanyo lweCalprotectinyokuvavanya