Impumelelo yoVavanyo olungaHlaseliyo:I-Fecal Calprotectin"Ukuwela imida" yoNceda ukuFunyaniswa kwangoko kwe-GI engaphezulu kubantwana

Kwinkalo yokuxilongwa kwezifo zenkqubo yokugaya abantwana, i-endoscopy sele ibe "ngumgangatho wegolide" wokumisela ukuvutha okuphezulu kwesisu. Nangona kunjalo, olu vavanyo oluhlaselayo alupheleli nje kuphela ukungonwabi ngokwasemzimbeni kubantwana, ngakumbi abancinci, kodwa kwakhona luzisa uloyiko olukhulu ngokwasengqondweni kunye nobunzima bokusebenzisaneni. Oku kwenza abazali abaninzi bathandabuze ngexesha lokuxilongwa kokuqala kwaye banokuphoswa ithuba lokungenelela kwangaphambili.Kutshanje, uphando olutsha lweklinikhi kunye nokusebenza kwesicelo kuye kwazisa iindaba ezimnandi:I-fecal calprotectin (FCP), isalathisi esikhulileyo esingahlaseliyo sovavanyo lwezifo ezisezantsi zesisu, sibonisa amandla amakhulu ekuxilongweni kwangaphambili kokuvuvukala kwamathumbu kubantwana, ukufezekisa "i-crossover" emangalisayo ukusuka "kumathumbu angaphantsi" ukuya "kumathumbu aphezulu".

Ukusuka kwiNgxaki “yoMgangatho weGolide” ukuya kuthi ga ekuqaleni koVavanyo olungaHlaziyo

Ukuvuvukala kwesisu esiphezulu esifana ne-gastritis kunye ne-gastroduodenitis ayiqhelekanga kubantwana, kwaye izizathu zabo ziquka ukusuleleka, iziyobisi, kunye nokuphendula uxinzelelo. Ngokwesiko, ukuxilongwa kufuna ukubonwa okubonakalayo kunye ne-tissue biopsy ngokusebenzisa i-gastroscopy, eyinkqubo enzima kwaye ephazamisayo. Iindlela zokufumanisa ezingabonakaliyo kunye nezilungeleyo ziye zahlala zilindeleke rhoqo kwiiklinikhi kunye neentsapho zabantwana abanesifo.I-calprotectin yefecalyiprotheyini ebonisa i-neutrophil aggregation. Xa i-mucosa yesisu ivutha, ukugxininiswa kwayo kuya kwanda kakhulu. Ukutyhubela iminyaka, isetyenziswe ngokubanzi kuvavanyo lomsebenzi wesifo sofuba (IBD) kunye nokuxilongwa ngokwahlukileyo kwesifo se-irritable bowel syndrome (IBS), ngokukodwa ukuvuvukala kwekholoni.

Uphando lwezenzululwazi luqinisekisa isiseko esiluqilima sezicelo "zokuwela umda".

Umzimba okhulayo wophando ubonisa ukuba le marker evuthayo ayiphelelanga kwikholoni. Xa ukuvuvukala okusebenzayo kwenzeka kwindawo ephezulu yesisu (njengesisu kunye ne-duodenum), iiseli ezivuthayo ziyangena kwaye zikhulule.calprotectin. Le proteni ihamba ngaphantsi kwendlela yokugaya kunye nolwelo lokugaya kunye neentsalela zokutya, ekugqibeleni zifunyenwe kwisitulo. Izifundo zakutsha nje ebantwaneni zibonise okoi-calprotectin yefecalamanqanaba aphezulu kakhulu kubantwana abane-gastritis eqinisekisiweyo ye-endoscopically okanye i-duodenitis xa kuthelekiswa nalabo abane-dyspepsia esebenzayo okanye iziphumo eziqhelekileyo ze-endoscopic.Nangona amanqanaba aphezulu e-FC abangelwa ukuvuvukala kwamathumbu aphezulu aphantsi ngokubanzi kune-IBD esebenzayo, baye babonisa ulwahlulo oluphawulekayo xa kuthelekiswa nabantu abaphilileyo. Oku kuphakamisa ukuba uvavanyo lwe-FC lunokusetyenziswa njengesixhobo sokuhlola esisebenzayo ukunceda oogqirha ekuqaleni ukuchonga abantwana abasemngciphekweni omkhulu wokudumba kwe-gastrointestinal ye-organic phakathi kwenani elikhulu labantwana ababonisa iimpawu ezinjengeentlungu zesisu, ukuqunjelwa, kunye nesicaphucaphu.

Ixabiso leklinikhi: Ukwakha iNdlela eNgcono yokuxilongwa kwabantwana

Ukusetyenziswa komda wei-calprotectin yefecalizise izibonelelo ezininzi ekuxilongeni nasekulawuleni izifo zesisu esiswini kubantwana:

I-1.Ukuthotyelwa kwe-1.Non-invasive and high: Kuphela isampuli encinci ye-stool efunekayo, kwaye inkqubo ayifuni ngokupheleleyo, enciphisa kakhulu umthwalo womzimba kunye nengqondo kubantwana. Abazali bayamkela kakhulu inkqubo, okwenza kube lula ukuqhuba ngokukhawuleza ukubeka iliso ngokuphindaphindiweyo kwiikliniki ezingaphandle.
2. Ukuhlola okusebenzayo kunye nesixhobo sokulinganisa: Kubantwana abaneempawu eziqhubekayo zesisu,I-Fecal Calprotectinuvavanyo lunokwenziwa kuqala ukuhlula ngokufanelekileyo phakathi kwezifo ezivuthayo kunye nokusebenza. UkubaI-calprotectin yefecalamanqanaba aqhelekile, izinto ezisebenzayo zinokubekwa phambili okanye unyango olunamandla kunye nokuqwalaselwa kunokwamkelwa. Ukuba amanqanaba e-FC aphakanyisiwe, inika isiseko esiqinileyo se-gastroscopy ehlaselayo, ukuphepha iinkqubo ezingadingekile ze-endoscopic kunye nokwandisa ulwabiwo lwezibonelelo zonyango.
3. Ukuvavanywa kokuncediswa kokusebenza kunye nokuphindaphinda: Emva kokuxilongwa kwe-inflammation ye-gastrointestinal kunye nokuqala kwonyango, ukubeka iliso okuguquguqukayo kotshintshoI-Fecal Calprotectinamanqanaba angasebenza njengesalathisi esijoliswe ekuvavanyeni ukuba ukuvutha kuphelile kwaye ingaba unyango lusebenza kakuhle. Kwakhona kunokunceda ukubona ukubuya kwesifo kwangoko.

Ikamva elizayo

Ngokuqinisekileyo, ukusetyenziswa kwe-fecal calprotectin kwindawo ephezulu yesisu kusafuna uphando olongezelelweyo ukucacisa ngokuchanekileyo ixabiso layo lokuqhawula kunye nokulawula ezinye izinto ezisezantsi zesisu ezinokubangela ukuba i-FC ephakamileyo. Nangona kunjalo, njengendlela yokuhlola ekhuselekileyo, elula, kunye nexabiso eliphantsi, ngokungathandabuzekiyo ivula umnyango omtsha wokuxilongwa kwangaphambili kokudumba kwamathumbu emathunjini kubantwana. Iphawula inyathelo eliya phambili ekuxilongweni kwezifo zokwetyisa kwabantwana ukuya kwindlela enobuntu nechanekileyo. Sikholelwa ukuba ngokuqhubeka kophando olunzulu kunye namava onyango aqokelelweyo,i-calprotectin yefecal,le “crossover star,” iya kuba nendima ebalulekileyo ngakumbi ekukhuseleni impilo yabantwana yokwetyisa.

I-Baysen Medical isoloko igxininisa ubuchule bokuxilonga ukuphucula umgangatho wobomi . Siphuhlise amaqonga obuchwepheshe ama-5- iLatex, igolide ye-colloidal, iFluorescence Immunochromatographic Assay, iMolekyuli, iChemiluminescence Immunoassay.SineColloidal GoldI-calprotectin yefecal ikhithi yovavanyo kunye neFluorescence ImmunoassayIkhithi yovavanyo lweCalprotectinkuvavanyo