I-Calprotectin yeNdle: Isixhobo Esibalulekileyo Sokuxilonga Ngokwahlukileyo Izifo Zesisu Esisezantsi

Kwimisebenzi yezonyango, ukuchongwa kwezifo ezisezantsi zesisu kudla ngokuba nemingeni, njengoko izifo ezininzi (ezifana nesifo samathumbu esidumbileyo, i-irritable bowel syndrome, kunye ne-infectious enteritis) zineempawu ezifanayo, nto leyo eyenza kube nzima ukwahlula ngokuchanekileyo ngokusekelwe kuphela kwiimpawu zeklinikhi kunye nokuhlolwa rhoqo.I-calprotectin yendle (FC), i-biomarker engangenisi ntsholongwane, enamandla aphezulu, ibonakalise ixabiso elikhulu ekuxilongweni okwahlukileyo kwezifo ezisezantsi zesisu kwiminyaka yakutshanje, ibe sisixhobo esisebenzayo sokunceda ekwenzeni izigqibo zonyango.

Yintoni i I-Calprotectin yeNdle?

I-Calprotectin yiproteni efumaneka kwi-cytoplasm yee-neutrophils. Xa kuvela ukudumba kwamathumbu, ii-neutrophils ziya kwi-mucosa yamathumbu kwaye zikhuphe i-calprotectin, nto leyo ekhokelela ekwandeni okuphawulekayo koxinzelelo lwayo kwindle. Ngenxa yokuzinza kwayo okuphezulu kunye nokulula kokubhaqwa, i-FC ibonisa ngokufanelekileyo inqanaba lokudumba kwamathumbu, inceda ukwahlula phakathi kwezifo zokudumba kwamathumbu (umz., IBD) kunye neemeko ezingezizo zokudumba (umz., IBS).

Izicelo kwiDiagnosis yoHlolo

1. Ukwahlula phakathi kwesifo samathumbu esivuthayo (IBD) kunye nesifo samathumbu esirhawuzelelwayo (IBS)
   I-IBD (kuquka isifo sikaCrohn kunye ne-ulcerative colitis) sisifo esingapheliyo sokudumba kwamathumbu, ngelixa i-IBS sisifo esingasebenziyo ngaphandle kwezilonda eziphilayo. Amanqanaba e-FC adla ngokunyuka kakhulu kwizigulane ze-IBD (ezidla ngokudlula i-100 μg/g), ngelixa ezo zikwi-IBS zihlala zikwinqanaba eliqhelekileyo (ngaphantsi kwe-50 μg/g). Ke ngoko, uvavanyo lwe-FC lunokusebenza njengesixhobo sokuhlola sokuqala, ukunciphisa iinkqubo ze-endoscopic ezingeyomfuneko, ukunciphisa iindleko zonyango, kunye nokuphucula ukusebenza kakuhle kokuxilonga.
2. Uvavanyo lomsebenzi wesifo se-IBD

Amanqanaba e-FC ahambelana kakuhle nomsebenzi wesifo kwi-IBD. Ukuhlolwa rhoqo kwe-FC kunceda ukuvavanya ukusebenza kakuhle konyango kunye nokuqikelela ukubuyela umva. Umzekelo, ukwehla kwe-FC ngexesha lonyango kubonisa ukudumba okulawulwayo, ngelixa ukunyuka okutsha kunokubonisa ukuphinda kwesifo, okukhokelela kuhlengahlengiso kwizicwangciso zonyango.

3. Ukwahluka kwe-enteritis esulelayo kwezinye izifo ezivuthayo

I-infectious enteritis (efana ne-bacterial okanye i-viral enteritis) inokubangela i-FC ephezulu, kodwa amanqanaba ahlala ephantsi kunalawo akwi-IBD kwaye ehla ngokukhawuleza njengoko usulelo luphela. Ukubeka iliso kwi-FC ngendlela eguqukayo kunceda ukwahlula usulelo oludlulayo kwizifo ezingapheliyo zokudumba.

4. Uvavanyo oluNcedisayo loMhlaza weColorectal

Nangona i-FC ingelulo uphawu oluthile lomhlaza we-colorectal, iithumba zamathumbu zihlala ziquka iimpendulo zokudumba ezikwindawo ethile, nto leyo ekhokelela ekunyukeni okuncinci ukuya kokuphakathi kwi-FC. Xa zidityaniswe nezinye iimvavanyo (umz., i-colonoscopy), i-FC inokubonelela ngolwazi olongezelelweyo lokuxilonga.

Iingenelo kunye nokunqongophala

Uvavanyo lweCalprotectin yendle Inika iingenelo ezifana nokungangenisi ntsholongwane, ukulula ukuyisebenzisa, kunye nexabiso eliphantsi, nto leyo eyenza ukuba ifaneleke kokubili ukuhlolwa kokuqala kunye nokuhlolwa kwexesha elide.IiCal zeNdle ayisiyongxaki ye-IBD kwaye inokubonwa nakwezinye iimeko (ezifana nosulelo lwamathumbu, iithumba, kunye ne-nonsteroidal anti-inflammatory drug-associated enteropathy). Ke ngoko, uvavanyo olupheleleyo olusekelwe kwiimpawu zeklinikhi, uvavanyo lwe-endoscopic, kunye nezifundo zobugcisa bomfanekiso luyimfuneko.

Isiphelo

I-calprotectin yendle Uvavanyo lubonelela ngesiseko esibalulekileyo sokuxilongwa ngokwahlukileyo kwezifo ezisezantsi zesisu, ingakumbi ukunceda ukwahlula i-IBD kwi-IBS kunye nokwenza ngcono ukuxilongwa kunye nonyango. Ngokuhambela phambili kubuchwepheshe bokuvavanya kunye nokusetyenziswa okunzulu kweklinikhi,i-calprotectin yendle iza kudlala indima enkulu ekulawuleni izifo zesisu, inike izigulane ukuxilongwa nonyango oluchanekileyo nolusebenzayo.

Ngokusebenzisa isayensii-calprotectin yendleNjengesixhobo, singanceda ngcono ekuxilongweni kwezonyango kwaye sincede ekulawuleni nasekunyangeni izifo ezisezantsi zesisu.

I-Baysen MedicalSisoloko sigxile kwindlela yokuxilonga ukuphucula umgangatho wobomi. Siphuhlise amaqonga obuchwephesha ama-5- iLatex, igolide ye-colloidal, uvavanyo lwe-Fluorescence Immunochromatographic, i-Molecular, i-Chemiluminescence Immunoassay. Uvavanyo olukhawulezayo lweCalprotectinkwayeMnauvavanyo lwe-mmunoassay Calprotectin ukuze kuhlolwe ukwenzakala kwezintso kwinqanaba lokuqala.