I-C-peptide, ekwabizwa ngokuba yi-linking peptide, yeyona amino acid ibalulekileyo kwimveliso ye-insulin. Ikhutshwa yi-pancreas ecaleni kwe-insulin kwaye isebenza njengophawu oluphambili lokuvavanya ukusebenza kwe-pancreatic. Ngelixa i-insulin ilawula amanqanaba eswekile yegazi, i-C-peptide idlala indima eyahlukileyo kwaye ibalulekile ekuqondeni iimeko ezahlukeneyo zempilo, ngakumbi isifo seswekile. Ngokulinganisa amanqanaba e-C-peptide, ababoneleli bezempilo banokuhlula phakathi kohlobo lwe-1 kunye nohlobo lwe-2 yeswekile, izigqibo zokukhokela unyango, kunye nokubeka iliso ekusebenzeni kwonyango.

Ukulinganisa amanqanaba e-C-peptide kubalulekile ekuxilongeni nasekulawuleni isifo seswekile. Abantu abanesifo seswekile sohlobo loku-1 badla ngokuba namanqanaba asezantsi okanye angabonakaliyo e-insulin kunye ne-C-peptide ngenxa yohlaselo lwamajoni omzimba kwiiseli ze-beta ezivelisa i-insulin. Ngakolunye uhlangothi, abantu abanesifo sikashukela sohlobo lwe-2 banokuba namanqanaba aqhelekileyo okanye aphakamileyo e-C-peptide ngenxa yokuba imizimba yabo ivelisa i-insulin kodwa iyaxhathisa kwimiphumo yayo. Ukubeka iliso kumanqanaba e-C-peptide kwizigulane, ezifana nezo zityhutyha i-islet cell transplants, kunokubonelela ngengqiqo ebalulekileyo kwimpumelelo yeenkqubo zonyango.

Uphononongo luye lwaphonononga iziphumo ezinokuthi zikhuseleke ze-C-peptide kwiithishu ezahlukeneyo. Olunye uphando lucebisa ukuba i-C-peptide inokuba neepropathi ezichasene nokudumba ezinokunceda ukunciphisa iingxaki ezinxulumene nesifo seswekile, njengomonakalo wemithambo-luvo kunye nezintso. Nangona i-C-peptide ngokwayo ayichaphazeli ngokuthe ngqo amanqanaba eglucose yegazi, isebenza njenge-biomarker ebalulekileyo yokulawula isifo sikashukela kunye nokulungelelanisa izicwangciso zonyango kwiimfuno zomntu ngamnye. Ukuba ufuna ukungena nzulu ekuqondeni seswekile, ukugcina upiindaba zoshishinoezinxulumene nokhathalelo lwempilo kunye nokuqhubela phambili kwezonyango kunokubonelela ngolwazi oluxabisekileyo kubo bobabini abaqeqeshi kunye nezigulana.