I-Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), intsholongwane ebangela ubhubhane wamva nje wesifo se-coronavirus ka-2019 (COVID-19), yintsholongwane ye-RNA enemigca enye, enomlinganiselo we-genome omalunga ne-30 kb. Iindidi ezininzi ze-SARS-CoV-2 ezineempawu ezahlukeneyo zokuguquka ziye zavela kulo lonke ubhubhane. Ngokuxhomekeke kwindawo yazo yokuguquka kweproteni, ezinye iintlobo zibonakalise ukusasazeka okuphezulu, usulelo, kunye nokuba yingozi.

Uluhlu lwe-BA.2.86 lwe-SARS-CoV-2, olwachongwa okokuqala ngo-Agasti 2023, lwahlukile ngokwe-phylogenetic kwiindidi ze-Omicron XBB ezisasazwayo ngoku, kuquka i-EG.5.1 kunye ne-HK.3. Uluhlu lwe-BA.2.86 luqulethe iinguqu ezingaphezu kwama-30 kwiproteni ye-spike, nto leyo ebonisa ukuba olu luhlu lunamandla okuphepha ukhuselo lwe-anti-SARS-CoV-2 olukhoyo.

I-JN.1 (BA.2.86.1.1) lolona hlobo lusandula ukuvela lwe-SARS-CoV-2 oluvela kumgca we-BA.2.86. I-JN.1 iqulethe utshintsho oluphawulekayo lwe-L455S kwiproteni ye-spike kunye nezinye iinguqulelo ezintathu kwiiproteni ezingezizo ze-spike. Izifundo eziphanda i-HK.3 kunye nezinye iinguqulelo ze-"FLip" zibonise ukuba ukufumana utshintsho lwe-L455F kwiproteni ye-spike kunxulunyaniswa nokwanda kokudluliselwa kwentsholongwane kunye nokukwazi ukuphepha amajoni omzimba. Utshintsho lwe-L455F kunye ne-F456L lubizwa ngegama elithi ""."Jikelezisa"utshintsho lwe-amino acids kuba lutshintsha indawo yee-amino acids ezimbini, ezibhalwe u-F no-L, kwiproteni ye-spike.

Thina baseBaysen Medical singakunika uvavanyo lobuqu lwe-COVID-19 ukuze ulusebenzise ekhaya, wamkelekile ukunxibelelana nathi ukuze ufumane iinkcukacha ezithe vetshe.