I-C-Reactive Protein (CRP) yiprotheni eveliswa yisibindi, kwaye amanqanaba ayo egazini aphakama kakhulu ekuphenduleni ukuvuvukala. Ukufunyanwa kwayo ngo-1930 kunye nophononongo olwalandelayo luye lwaqinisa indima yalo njengenye yezona zinto zibalulekileyo kwaye zisetyenziswa kakhulu kwi-biomarker kumayeza anamhlanje. Ukubaluleka kovavanyo lwe-CRP kuluncedo lwayo njengento enovakalelo, nangona ingacaciswanga, isalathisi sokudumba, ukunceda ekuxilongeni, ukucwangciswa komngcipheko, kunye nokubeka iliso kuluhlu lweemeko ezininzi.

1. Isiphawuli esibuthathaka sosulelo kunye nokudumba
Esinye sezicelo eziphambili ze-CRP kukufumanisa nokulawula usulelo, ngakumbi usulelo lwebhaktiriya. Ngelixa ukunyuka kwe-CRP kuyimpendulo ngokubanzi ekudumbeni, amanqanaba anokuthi anyuke kakhulu kwizifo ezinzima zebhaktheriya, zihlala zidlula i-100 mg / L. Oku kuyenza ixabiseke ekwahluleni iintsholongwane kusulelo lwentsholongwane, njengoko olu lwamva lubangela ukonyuka okuphantsi. Kwiimeko zeklinikhi, i-CRP isetyenziselwa ukuxilonga iimeko ezifana nenyumoniya, i-sepsis, kunye nosulelo lwasemva kotyando. Ngokomzekelo, ukubeka iliso kumanqanaba e-CRP emva kokuhlinzwa kunceda oogqirha ukuba bachonge iingxaki ezifana nosulelo lwamanxeba okanye amathumba anzulu kwangaphambili, okuvumela ukungenelela ngokukhawuleza. Kwakhona kuluncedo ekulawuleni izifo ezingapheliyo ezivuthayo ezifana ne-rheumatoid arthritis kunye nesifo samathumbu esivuthayo (IBD), apho imilinganiselo ye-serial inceda ukulinganisa umsebenzi wesifo kunye nokusebenza konyango oluchasayo.

2. Uvavanyo loMngcipheko weCardiovascular: hs-CRP
Inkqubela phambili enkulu kwintsimi yaba kuphuhliso lovavanyo lwe-CRP (hs-CRP) olunovakalelo oluphezulu. Olu vavanyo lulinganisa amanqanaba asezantsi kakhulu e-CRP, awayengabonakali ngaphambili. Uphando luye lwafumanisa ukuba ukuvuvukala okungapheliyo, okuphantsi komgangatho ophantsi kweendonga ze-arterial ngumqhubi oyintloko we-atherosclerosis-i-buildup of plaque engakhokelela ekuhlaselweni kwentliziyo kunye nokubetha. I-hs-CRP isebenza njenge-biomarker eyomeleleyo yolu kuvuvukala kwe-vascular.
I-American Heart Association iyaqaphela i-hs-CRP njengengozi ezimeleyo yesifo senhliziyo. Abantu abanamazinga e-hs-CRP kuluhlu oluphezulu oluqhelekileyo (ngaphezu kwe-3 mg / L) babhekwa njengomngcipheko okhulayo weziganeko zenhliziyo ezizayo, nokuba amanqanaba abo e-cholesterol aqhelekile. Ngenxa yoko, i-hs-CRP isetyenziselwa ukucokisa uvavanyo lomngcipheko, ngakumbi kwizigulane ezinomngcipheko ophakathi. Oku kuvumela izicwangciso zothintelo ezizezakho, ezinjengokuqalisa unyango lwe-statin kubantu abanokuthi ngenye indlela banganyangwa ngokusekelwe kumngcipheko wesintu kuphela.

3. Ukubeka iliso kwiMpendulo yoNyango kunye nePrognosis
Ngaphandle kokuxilongwa kunye novavanyo lomngcipheko, i-CRP sisixhobo esihle kakhulu sokuhlola impendulo yesigulane kunyango. Kwizifo ezithathelwanayo, inqanaba le-CRP eliwayo liyisalathisi esinamandla sokuba i-antibiotic okanye unyango lwe-antimicrobial luyasebenza. Ngokufanayo, kwiimeko ezizimelayo, ukuncipha kwe-CRP ehambelanayo kunye nokunyanzeliswa ngempumelelo kokuvuvukala ngamachiza e-immunosuppressive. Olu tshintsho lwendalo luvumela oogqirha ukuba bahlengahlengise izicwangciso zonyango ngexesha lokwenyani. Ngapha koko, amanqanaba aphezulu e-CRP ahlala enxulunyaniswa ne-prognosis embi kakhulu kwiimeko ezisuka kumhlaza ukuya kukusilela kwentliziyo, ukubonelela ngefestile kubunzulu besifo kunye ne-trajectory.

Unyino kunye nesiphelo
Ngaphandle kokusetyenziswa kwayo, umda obalulekileyo we-CRP kukungacaci kwayo. Inqanaba eliphakamileyo libonisa ubukho bokuvuvukala kodwa ayichazi isizathu sayo. Uxinzelelo, umonzakalo, ukutyeba, kunye neemeko ezingapheliyo zinokunyusa i-CRP. Ngoko ke, iziphumo zayo kufuneka zihlale zitolikwa kumxholo wembali yekliniki yesigulane, ukuhlolwa komzimba, kunye nezinye iziphumo zokuxilonga.

Ukuqukumbela, ukubaluleka kovavanyo lwe-CRP kuninzi. Ukusuka ekusebenzeni njengovavanyo lwangaphambili losulelo olubukhali ukuya ekusebenzeni njengengqikelelo entsonkothileyo yomngcipheko wexesha elide wentliziyo ngokusebenzisa i-hs-CRP, le biomarker sisixhobo esiyimfuneko kwisixhobo sonyango. Ukukwazi kwayo ukulinganisa ngokufanelekileyo kunye nokubeka iliso kukuvuvukala kuye kwaphucula kakhulu ukhathalelo lwesigulana ekuxilongweni, isikhokelo sonyango, kunye novavanyo oluqikelelweyo kuzo zonke iingcali zonyango ezininzi.