I-Cardiac Troponin T (cTnT), iyunithi encinci ye-troponin complex ebonakaliswa ngokukodwa kwi-cardiac myocytes, ime njengenye yezona biomarkers ziguqulayo neziyimfuneko kakhulu kunyango lwentliziyo yanamhlanje. Ukubaluleka kwayo kusekelwe kwi-specific yayo ekhethekileyo yentliziyo, uvakalelo oluphezulu, kunye nendima yayo ephambili ekuxilongweni, ukwahlulwahlulwa komngcipheko, kunye nolawulo lwe-acute coronary syndromes (ACS) kunye nezinye iingozi zentliziyo.

Eyona nto iphambili, i-cTnT yeyona nto ibalulekileyo ekuxilongweni kwe-myocardial infarction (MI). Ngaphambi kokwamkelwa kwe-troponin, ukuxilongwa kwakuxhomekeke kwiimpawu ezingachazwanga kangako njengeCreatine Kinase-MB (CK-MB) kunye neempawu zeklinikhi, nto leyo ekhokelela ekungaqinisekini kokuxilongwa. Ukukhululwa kwe-cTnT egazini emva kwe-myocardial necrosis kuxhomekeke kakhulu kumonakalo wemisipha yentliziyo. Ukufika kovavanyo lwe-troponin T (hs-cTnT) olunovakalelo oluphezulu kuye kwaguqula ngakumbi eli candelo. Olu vavanyo lunokubona ukuphakama okuncinci kwe-cTnT ngaphantsi komda we-99th percentile upper reference we-normal population. Oku kuvumela oogqirha ukuba bachonge ukwenzakala kwe-myocardial kwangethuba kakhulu—ngokuqhelekileyo kwiiyure ezi-1-3 zokubonakaliswa kwesebe likaxakeka—okuvumela ukulawulwa ngokukhawuleza kwaye, okubalulekileyo, ukulawulwa ngokukhawuleza nangokuqinisekileyo kwe-MI. Oku kukhawulezisa unyango lwezinto ezilungileyo kwaye kukhulula ngokukhuselekileyo izigulane ezisengozini ephantsi, kuphucula ukusebenza kakuhle kwesebe likaxakeka kunye nokuhamba kwezigulane.

Ngaphaya kokuxilongwa, i-cTnT idlala indima ebalulekileyo ekuhlulweni komngcipheko kunye nokuqikelela kwangaphambili. Ubukhulu bokunyuka kwe-cTnT buhambelana kakhulu nobungakanani bomonakalo we-myocardial kwaye bubungqina obunamandla obuzimeleyo beziphumo ezimbi zexesha elifutshane nelide, kubandakanya ukusilela kwentliziyo, ukuhlaselwa yintliziyo okuphindaphindiweyo, kunye nokufa. Nokuba ukuphakama okuncinci, okungapheliyo okufunyenweyo ngovavanyo lwe-hs-cTnT kwizigulana ezibonakala zizinzile kunokuchonga abo banokulimala kwe-myocardial okungaphantsi kweklinikhi, okubonisa umngcipheko ophezulu weziganeko zentliziyo kwixesha elizayo. Oku kwenza i-cTnT ibe sisixhobo esixabisekileyo kungekuphela nje kwiimeko ezibukhali kodwa nasekulawuleni iimeko ezingapheliyo ezifana nesifo se-coronary artery esizinzileyo, ukungaphumeleli kwentliziyo, kunye nesifo sezintso esingapheliyo.

Ngaphezu koko, umlinganiselo we-cTnT ukhokela ukwenziwa kwezigqibo ezibalulekileyo zonyango. Ipateni enyukayo kunye/okanye ehlayo ye-cTnT ibalulekile ekuchazeni i-MI ebukhali ngokwezikhokelo zehlabathi. Olu qinisekiso lwe-biochemical luzisa ngokuthe ngqo ukungenelela okungxamisekileyo okufana ne-coronary angiography kunye ne-revascularization (PCI okanye i-CABG). Ikwanceda ekukhetheni nasekujongeni ukusebenza kakuhle konyango lwe-pharmacological, kubandakanya ii-antiplatelet agents ezinamandla (umz., i-ticagrelor, i-prasugrel) kunye ne-anticoagulants.

Ukubaluleka kwe-cTnT kufikelela nakwiimeko zentliziyo ezingezizo eze-ischemic. Amanqanaba aphezulu abonakala kwiindlela ezahlukeneyo apho kwenzeka khona uxinzelelo lwentliziyo okanye ukwenzakala, okufana ne-myocarditis, ukudumba kwentliziyo, i-sepsis enzima, i-pulmonary embolism ebangela uxinzelelo lwentliziyo yasekunene, kunye ne-cardiotoxicity enxulumene ne-chemotherapy. Kule meko, i-cTnT isebenza njengophawu olubuthathaka lokubandakanyeka kwentliziyo, nto leyo ekhuthaza uphando olongezelelweyo kunye nolawulo olucwangcisiweyo.

Ukuqukumbela, iCardiac Troponin T itshintshe ngokusisiseko indlela yokusebenza kwentliziyo. Ukuguquka kwayo ibe luvavanyo olunovakalelo oluphezulu kuye kwaqinisa imeko yayo njenge-biomarker ephambili yokwenzakala kwentliziyo. Ngokubonelela ngokuchanekileyo kokuxilongwa okungenakuthelekiswa nanto, ulwazi olunamandla lokuxela kwangaphambili, kunye nesikhokelo esibalulekileyo sonyango olusindisa ubomi, i-cTnT ibalulekile ekuphuculeni iziphumo zesigulana kwiimeko ezingxamisekileyo zentliziyo kunye nolawulo lwexesha elide lwesifo sentliziyo. Ukulinganisa kwayo ngumgangatho ongenakuphikiswana ngawo kunyango lwentliziyo lwanamhlanje.