I-Interleukin-6 iyi-polypeptide equkethe amaketanga amabili e-glycoprotein, anesisindo sama-molecule esingu-130kd. Njengelungu elibalulekile lenethiwekhi ye-cytokine, i-interleukin-6 (IL-6) idlala indima ebalulekile ekusabeleni okubukhali kokuvuvukala, futhi ingalawula ukusabela kwesigaba esibukhali kwesibindi, futhi ikhuthaze ukukhiqizwa kweprotheyini ye-C-reactive (CRP) kanye ne-fibrinogen. Izifo eziningi ezithelelanayo zingaholela ekukhuphukeni kwezinga le-IL-6 egazini, futhi izinga le-IL-6 lihlotshaniswa kakhulu nemiphumela yeziguli. Njenge-cytokine ye-pleiotropic enemisebenzi eminingi, i-IL-6 ikhishwa yi-T cell, iseli le-B, i-mononuclear phagocyte, kanye neseli le-endothelial, futhi iyingxenye ebalulekile yenethiwekhi yomlamuleli wokuvuvukala. Lapho kuvela ukusabela okubukhali, i-IL-6 ikhiqizwa kuqala, okubangela ukukhiqizwa kwe-CRP kanye ne-procalcitonin (PCT) lapho ikhiqizwa. Izokhiqizwa ngokushesha uma kwenzeka ukutheleleka, ukulimala kwangaphakathi nangaphandle, ukuhlinzwa, ukusabela kokucindezeleka, ukufa kobuchopho, i-tumorigenesis, kanye nenqubo yokusabela okubukhali kokuvuvukala kwezinye izimo. I-IL-6 ihilelekile ekuveleni nasekuthuthukisweni kwezifo eziningi, izinga layo legazi lihlotshaniswa kakhulu nokuvuvukala, ukutheleleka ngegciwane kanye nesifo sokuzivikela komzimba, futhi izinguquko zalo zenzeka ngaphambi kwe-CRP. Ngokusho kwemiphumela yocwaningo, izinga le-IL-6 likhuphuka ngokushesha lapho kutheleleka amagciwane, izinga le-PCT liyanda ngemva kwamahora ama-2, kuyilapho i-CRP ikhula ngokushesha ngemva kwamahora ama-6. Ukukhiqizwa okungajwayelekile noma ukubonakaliswa kwezakhi zofuzo kwe-IL-6 kuvame ukuholela ekuveleni kwezifo eziningi, inani elikhulu le-IL-6 lingakhishwa egazini esimweni se-pathological, futhi ukutholakala kwe-IL-6 kubaluleke kakhulu ekuxilongweni kwesifo kanye nokwahlulela kokubikezela.