I-C-peptide, eyaziwa nangokuthi i-linking peptide, iyi-amino acid ebalulekile ekukhiqizweni kwe-insulin. Ikhishwa yi-pancreas kanye ne-insulin futhi isebenza njengophawu olubalulekile lokuhlola umsebenzi we-pancreatic. Ngenkathi i-insulin ilawula amazinga kashukela egazini, i-C-peptide idlala indima ehlukile futhi ibalulekile ekuqondeni izimo ezahlukene zempilo, ikakhulukazi isifo sikashukela. Ngokulinganisa amazinga e-C-peptide, abahlinzeki bezempilo bangahlukanisa phakathi kwesifo sikashukela sohlobo 1 nohlobo 2, baqondise izinqumo zokwelashwa, futhi baqaphe ukusebenza kahle kokwelashwa.

Ukulinganisa amazinga e-C-peptide kubalulekile ekuxilongeni nasekuphatheni isifo sikashukela. Abantu abanesifo sikashukela sohlobo 1 bavame ukuba namazinga aphansi noma angatholakali e-insulin kanye ne-C-peptide ngenxa yokuhlasela kwesimiso somzimba sokuzivikela kumaseli e-beta akhiqiza i-insulin. Ngakolunye uhlangothi, abantu abanesifo sikashukela sohlobo 2 bangase babe namazinga e-C-peptide ajwayelekile noma aphezulu ngoba imizimba yabo ikhiqiza i-insulin kodwa imelana nemiphumela yayo. Ukuqapha amazinga e-C-peptide ezigulini, njengalabo abafakelwa amaseli e-islet, kunganikeza ukuqonda okubalulekile ngempumelelo yezinqubo zezokwelapha.

Izifundo ziphinde zahlola imiphumela engaba khona yokuvikela ye-C-peptide ezicutshini ezahlukahlukene. Olunye ucwaningo lusikisela ukuthi i-C-peptide ingaba nezakhiwo zokulwa nokuvuvukala ezingasiza ekunciphiseni izinkinga ezihambisana nesifo sikashukela, njengokulimala kwezinzwa nezinso. Nakuba i-C-peptide ngokwayo ingathinti ngqo amazinga kashukela egazini, isebenza njenge-biomarker ebalulekile yokuphatha isifo sikashukela kanye nokwenza izinhlelo zokwelapha zivumelane nezidingo zomuntu ngamunye. Uma ufuna ukujula ekuqondeni isifo sikashukela, ukuhambisana neizindaba zebhizinisiokuhlobene nokunakekelwa kwempilo kanye nentuthuko yezokwelapha kunganikeza ukuqonda okubalulekile kokubili kochwepheshe kanye neziguli.