I-C-peptide, eyaziwa nangokuthi i-peptide exhumanisa, iyi-amino acid ebalulekile ekukhiqizeni i-insulin. Ikhishwa ama-pancreas kanye ne-insulin futhi isebenza njengomaka obalulekile wokuhlola ukusebenza kwe-pancreatic. Nakuba i-insulin ilawula amazinga kashukela egazini, i-C-peptide idlala indima ehlukile futhi ibalulekile ekuqondeni izimo ezihlukahlukene zempilo, ikakhulukazi isifo sikashukela. Ngokulinganisa amazinga e-C-peptide, abahlinzeki bezokunakekelwa kwempilo bangakwazi ukuhlukanisa phakathi kohlobo loku-1 nesifo sikashukela sohlobo 2, baqondise izinqumo zokwelashwa, futhi baqaphe ukusebenza kahle kokwelashwa.

Ukulinganisa amazinga e-C-peptide kubalulekile ekuxilongeni nasekulawuleni isifo sikashukela. Abantu abanesifo sikashukela sohlobo loku-1 ngokuvamile banamazinga aphansi noma angatholakali e-insulini kanye ne-C-peptide ngenxa yokuhlasela kwamasosha omzimba kumaseli e-beta akhiqiza i-insulin. Ngakolunye uhlangothi, abantu abanesifo sikashukela sohlobo 2 bangase babe namazinga e-C-peptide avamile noma aphakeme ngoba imizimba yabo ikhiqiza i-insulin kodwa imelana nemiphumela yayo. Ukuqapha amazinga e-C-peptide ezigulini, njengalezo ezifakelwa ama-islet cell, kunganikeza imininingwane ebalulekile empumelelweni yezinqubo zezokwelapha.

Ucwaningo luphinde lwahlola imiphumela engaba khona yokuvikela ye-C-peptide ezicutshini ezihlukahlukene. Olunye ucwaningo lubonisa ukuthi i-C-peptide ingase ibe nezinto ezilwa nokuvuvukala ezingasiza ekwehliseni izinkinga ezihlobene nesifo sikashukela, njengokulimala kwemizwa nezinso. Nakuba i-C-peptide ngokwayo isithinti ngokuqondile amazinga kashukela egazini, isebenza njenge-biomarker ebalulekile yokulawula isifo sikashukela kanye nokuhlanganisa izinhlelo zokwelashwa ezidingweni zomuntu ngamunye. Uma ufuna ukujula ekuqondeni isifo sikashukela, ukuhambisanaizindaba zebhizinisiokuhlobene nokunakekelwa kwezempilo kanye nokuthuthuka kwezokwelapha kunganikeza imininingwane ebalulekile kubo bobabili ochwepheshe kanye neziguli.