I-C-Reactive Protein (CRP) iphrotheni ekhiqizwa isibindi, futhi amazinga ayo egazini akhuphuka kakhulu ekuphenduleni ukuvuvukala. Ukutholwa kwayo ngo-1930 kanye nocwaningo olwalandela kwaqinisa indima yayo njengenye yezimpawu ezibaluleke kakhulu nezisetshenziswa kabanzi kwezokwelapha zesimanje. Ukubaluleka kokuhlolwa kwe-CRP kusekusetshenzisweni kwayo njengenkomba ebucayi, nakuba ingaqondile, yokuvuvukala, esiza ekuxilongeni, ekuhlukaniseni ubungozi, kanye nokuqapha inqwaba yezimo.

1. Umaka Ozwelayo Wokutheleleka Nokuvuvukala
Esinye sezicelo eziyinhloko ze-CRP sisekutholeni nasekulawuleni izifo, ikakhulukazi izifo ezibangelwa amagciwane. Nakuba ukwenyuka kwe-CRP kuyimpendulo evamile ekuvuvukeni, amazinga angakhuphuka kakhulu ezifweni ezinzima zamagciwane, ngokuvamile ezedlula i-100 mg/L. Lokhu kwenza kube wusizo olukhulu ekuhlukaniseni amagciwane nezifo ezibangelwa amagciwane, njengoba lokhu kwakamuva kubangela ukuphakama okunesizotha. Ezilungiselelweni zomtholampilo, i-CRP isetshenziselwa ukuxilonga izimo ezifana nenyumoniya, i-sepsis, nezifo zangemva kokuhlinzwa. Isibonelo, ukuqapha amazinga e-CRP ngemva kokuhlinzwa kusiza odokotela ukuthi babone izinkinga ezifana nokutheleleka kwesilonda noma amathumba ajulile kusenesikhathi, okuvumela ukungenelela ngokushesha. Kuwusizo futhi ekulawuleni izifo ezingapheli ezivuvukalayo njenge-rheumatoid arthritis kanye nesifo samathumbu esivuvukalayo (IBD), lapho izilinganiso ze-serial zisiza ukukala umsebenzi wesifo kanye nempumelelo yokwelapha okulwa nokuvuvukala.

2. Ukuhlolwa Kwengozi Yenhliziyo: hs-CRP
Intuthuko enkulu kulo mkhakha kwaba ukuthuthukiswa kokuhlolwa kwe-CRP (hs-CRP) ezwela kakhulu. Lokhu kuhlola kukala amazinga aphansi kakhulu e-CRP, abengatholakali ngaphambilini. Ucwaningo luye lwathola ukuthi ukuvuvukala okungapheli, okuphansi kwezindonga ngaphakathi kwezindonga zemithambo kuyimbangela eyinhloko ye-atherosclerosis-ukwakheka kwe-plaque engaholela ekuhlaselweni kwenhliziyo nokushaywa unhlangothi. I-hs-CRP isebenza njenge-biomarker eqinile yalokhu kuvuvukala kwemithambo engaphansi.
I-American Heart Association ibona i-hs-CRP njengento ezimele engozini yesifo senhliziyo. Abantu abanamazinga e-hs-CRP ebangeni eliphezulu elivamile (ngaphezu kuka-3 mg/L) babhekwa njengabasengozini eyengeziwe yezehlakalo zenhliziyo zesikhathi esizayo, ngisho noma amazinga e-cholesterol abo avamile. Ngenxa yalokho, i-hs-CRP isetshenziselwa ukucolisisisa ukuhlolwa kwengozi, ikakhulukazi ezigulini ezisengozini ephakathi. Lokhu kuvumela amasu okuvimbela aqondene nawe kakhulu, njengokuqala ukwelashwa ngama-statin kubantu okungenzeka bangelashwa ngokusekelwe ezicini ezivamile zobungozi kuphela.

3. Ukuqapha Ukusabela Kokwelashwa kanye Nesibikezelo
Ngaphandle kokuxilongwa nokuhlola ubungozi, i-CRP iyithuluzi elihle kakhulu lokuqapha impendulo yesiguli ekwelashweni. Ezifweni ezithathelwanayo, izinga le-CRP eliwayo liyinkomba eqinile yokuthi i-antibiotic noma i-antimicrobial therapy iyasebenza. Ngokufanayo, ezimweni ze-autoimmune, ukwehla kwe-CRP kuhlotshaniswa nokucindezelwa okuphumelelayo kokuvuvukala ngezidakamizwa ze-immunosuppressive. Le mvelo eguquguqukayo ivumela odokotela ukuthi balungise izinhlelo zokwelashwa ngesikhathi sangempela. Ngaphezu kwalokho, amazinga e-CRP aqhubekayo avame ukuhlotshaniswa nokubikezelwa okubi kakhulu ezimweni ezisukela kumdlavuza kuye ekuhlulekeni kwenhliziyo, okuhlinzeka ngefasitela lokuqina kwesifo kanye ne-trajectory.

Imikhawulo kanye nesiphetho
Ngaphandle kokusetshenziswa kwayo, umkhawulo obalulekile we-CRP ukungacacisi kwayo. Izinga eliphakeme libonisa ukuba khona kokuvuvukala kodwa alisho imbangela yako. Ukucindezeleka, ukuhlukumezeka, ukukhuluphala, kanye nezimo ezingapheli konke kungakhuphula i-CRP. Ngakho-ke, imiphumela yayo kufanele ihlale ihunyushwa kumongo womlando womtholampilo wesiguli, ukuhlolwa ngokomzimba, nokunye okutholwe kokuxilonga.

Sengiphetha, ukubaluleka kokuhlolwa kwe-CRP kuningi. Kusukela ekusebenzeni njengokuhlola okuphambili kwezifo eziyingozi kuya ekusebenzeni njengesibikezelo esiyinkimbinkimbi sengozi yesikhathi eside yenhliziyo nemithambo yegazi ngokusebenzisa i-hs-CRP, le biomarker iyithuluzi elibalulekile kuzikhali zodokotela. Ikhono layo lokulinganisa ngokufanelekile kanye nokuqapha ukuvuvukala likuthuthukise kakhulu ukunakekelwa kwesiguli ekuxilongweni, ekuqondisweni kokwelashwa, nasekuhloleni okubikezelwe kuzo zonke izici eziningi zezokwelapha.