I-Cardiac Troponin T (cTnT), iyunithi encane ye-troponin complex evezwa ngokukhethekile kuma-myocyte enhliziyo, iphakathi kwezimpawu eziguqula kakhulu futhi ezibalulekile kwezokwelapha zenhliziyo zanamuhla. Ukubaluleka kwayo kusekelwe ekuqondeni kwayo okuhlukile kwenhliziyo, ukuzwela okuphezulu, kanye nendima yayo ebalulekile ekuxilongweni, ekuhlukanisweni kwezingozi, kanye nokuphathwa kwe-acute coronary syndromes (ACS) kanye nokunye ukulimala kwenhliziyo.

Okubaluleke kakhulu, i-cTnT iyi-biomarker eyisisekelo yokuxilonga i-myocardial infarction (MI). Ngaphambi kokwamukelwa kwe-troponin, ukuxilongwa kwakuncike ezimpawini ezingacacile kangako njenge-Creatine Kinase-MB (CK-MB) kanye nezimpawu zomtholampilo, okuholela ekungaqiniseki kokuxilongwa. Ukukhishwa kwe-cTnT egazini ngemuva kwe-myocardial necrosis kuqondile kakhulu ekulimaleni kwemisipha yenhliziyo. Ukufika kokuhlolwa kwe-troponin T (hs-cTnT) okuzwela kakhulu kuye kwaguqula kakhulu le nsimu. Lokhu kuhlolwa kungathola ukuphakama okuncane kwe-cTnT ngaphansi komkhawulo we-99th percentile wereferensi ephezulu yabantu abavamile. Lokhu kuvumela odokotela ukuthi babone ukulimala kwe-myocardial kusenesikhathi kakhulu—ngokuvamile kungakapheli amahora angu-1-3 okwethulwa komnyango ophuthumayo—okuvumela ukulawulwa okusheshayo futhi, okubaluleke kakhulu, ukulawulwa okusheshayo nokuqinisekile kokuphuma kwe-MI. Lokhu kusheshisa ukwelashwa kwemiphumela emihle yangempela futhi kukhulula ngokuphephile iziguli ezisengozini ephansi, kuthuthukise ukusebenza kahle komnyango ophuthumayo kanye nokugeleza kweziguli.

Ngaphandle kokuxilongwa, i-cTnT idlala indima ebalulekile ekuhlukanisweni kwengozi kanye nokubikezela. Ubukhulu bokuphakama kwe-cTnT buhlobene kakhulu nobukhulu bomonakalo we-myocardial futhi buyisibikezelo esinamandla esizimele semiphumela emibi yesikhathi esifushane neside, okuhlanganisa ukwehluleka kwenhliziyo, ukuhlaselwa yinhliziyo okuphindaphindiwe, kanye nokufa. Ngisho nokuphakama okuncane, okungapheli okutholakala ngokuhlolwa kwe-hs-cTnT ezigulini ezibonakala zizinzile kungabona labo abanokulimala kwe-myocardial okungaphansi kwe-clinical, okubonisa ingozi ephezulu yezehlakalo zenhliziyo zesikhathi esizayo. Lokhu kwenza i-cTnT ibe ithuluzi eliwusizo hhayi kuphela ezimweni ezibucayi kodwa futhi nasekuphatheni izimo ezingamahlalakhona njengesifo se-coronary artery esizinzile, ukwehluleka kwenhliziyo, kanye nesifo sezinso esingamahlalakhona.

Ngaphezu kwalokho, ukulinganisa kwe-cTnT kuqondisa ukwenziwa kwezinqumo ezibalulekile zokwelapha. Iphethini ekhuphukayo kanye/noma ewayo ye-cTnT ibalulekile ekuchazeni i-MI ebukhali ngokweziqondiso zomhlaba wonke. Lokhu kuqinisekiswa kwamakhemikhali kwazisa ngqo ukungenelela okuphuthumayo njenge-coronary angiography kanye ne-revascularization (PCI noma i-CABG). Kuphinde kusize ekukhetheni nasekuqapheni ukusebenza kahle kwezindlela zokwelapha zemithi, kufaka phakathi ama-antiplatelet agents anamandla (isb., i-ticagrelor, i-prasugrel) kanye nama-anticoagulants.

Ukubaluleka kwe-cTnT kufinyelela ezimweni zenhliziyo ezingezona eze-ischemic. Amazinga aphezulu abonakala ezifweni ezahlukahlukene lapho kwenzeka khona ukucindezeleka noma ukulimala kwenhliziyo, njenge-myocarditis, ukuminyana kwenhliziyo, i-sepsis enzima, i-pulmonary embolism ebangela ukucindezeleka kwenhliziyo kwesokudla, kanye nobuthi benhliziyo obuhlobene ne-chemotherapy. Kulezi zimo, i-cTnT isebenza njengesibonakaliso esibucayi sokubandakanyeka kwenhliziyo, okubangela uphenyo olwengeziwe kanye nokuphathwa okulungiselelwe.

Ekuphetheni, i-Cardiac Troponin T ishintshe ngokuphelele umkhuba we-cardiology. Ukuthuthuka kwayo ekubeni yi-high sensitivity assay kuqinise isimo sayo njenge-biomarker ehamba phambili yokulimala kwe-myocardial. Ngokunikeza ukunemba okungenakuqhathaniswa kokuxilonga, ulwazi olunamandla lokubikezela, kanye nesiqondiso esibalulekile sezindlela zokwelapha ezisindisa impilo, i-cTnT ibalulekile ekuthuthukiseni imiphumela yeziguli kokubili ezimweni eziphuthumayo zenhliziyo kanye nokuphathwa kwesikhathi eside kwesifo senhliziyo. Ukulinganisa kwayo kuyindinganiso engaxoxiswani ekunakekelweni kwenhliziyo kwanamuhla.