Alamar Halitta don Cutar Gastritis na Atrophic: Ci gaban Bincike

Ciwon gastritis na yau da kullun (CAG) cuta ce ta yau da kullun wacce ke da alaƙa da asarar glandan mucosal na ciki a hankali da raguwar aikin ciki. A matsayin wani muhimmin mataki na ciwon ciki na ciwon ciki, ganewar farko da kuma kula da CAG suna da mahimmanci don hana ci gaban ciwon daji na ciki. A cikin wannan takarda, za mu tattauna manyan masu amfani da kwayoyin halitta na yanzu da aka yi amfani da su don tantancewa da saka idanu CAG da ƙimar aikace-aikacen su na asibiti.

I. Serologic BioMarkers

1. Pepsinogen (PG)ThePGⅠ/PGⅡ rabo (PGⅠ/PGⅡ) shine alamar serologic da aka fi amfani dashi don CAG.

• Rage matakan PGⅠ da PGⅠ/PGⅡrabo yana da alaƙa da mahimmanci tare da matakin atrophy na jikin ciki.
• Jagororin Jafananci da na Turai sun haɗa da gwajin PG a cikin shirye-shiryen tantance cutar kansar ciki

2.Gastrin-17 (G-17)

• Yana nuna matsayin aikin endocrine na sinus na ciki.
• Ragewar atrophy na sinus na ciki kuma yana iya haɓaka atrophy na jikin ciki.
• Haɗe tare da PG don haɓaka daidaiton binciken CAG

3.Anti-Parietal Cell Antibodies (APCA) da Anti-Intrinsic Factor Antibodies (AIFA)

• Alamomi na musamman don gastritis na autoimmune.
• Taimakawa wajen bambanta gastritis autoimmune daga sauran nau'ikan CAG

2. Histological Biomarkers

1. CDX2 da MUC2
   • Kwayoyin sa hannu na chemotaxis na hanji
   • Upregulation yana nuna hanjin mucosal na ciki.
2. p53 da Ki-67
   • Ma'ana na yaɗuwar tantanin halitta da bambance-bambancen da ba na al'ada ba.
   • Taimaka tantance haɗarin ciwon daji a cikin CAG.
3. Helicobacter pylori (H. pylori)- Alamomi masu alaƙa
   • Gano abubuwan da ke haifar da ƙwayoyin cuta kamar CagA da VacA.
   • Gwajin numfashi na Urea (UBT) da gwajin antigen stool.

3. Abubuwan Kwayoyin Halitta masu tasowa

1. microRNAs
   • miR-21, miR-155 da sauran su ana bayyana su a cikin CAG
   • Ƙimar bincike da ƙima.
2. DNA Methylation Markers
   • Tsarin methylation mara kyau a cikin yankuna masu tallata wasu kwayoyin halitta
   • Matsayin methylation na kwayoyin halitta kamar CDH1 da RPRM
3. Metabolomic Biomarkers
   • Canje-canje a cikin takamaiman bayanan metabolite suna nuna yanayin mucosa na ciki
   • Sabbin ra'ayoyi don bincikar cututtuka marasa lalacewa

4. Aikace-aikace na Clinical da Halayen Gaba

Haɗe-haɗen gwaje-gwaje na masu alamar halitta na iya inganta haɓakar hankali da ƙayyadaddun ganewar CAG. A nan gaba, ana sa ran haɗaɗɗun nazarin omics da yawa don samar da ƙarin haɓakar haɗin gwiwar alamomin halittu don madaidaicin bugu, ƙayyadaddun haɗari da sa ido na mutum ɗaya na CAG.

Mu Baysen Medical ƙwararre ne a cikin bincike da haɓaka haɓakar cututtukan cututtukan cututtukan cututtukan ƙwayoyin cuta, kuma mun haɓaka.PGⅠ, PGⅡ kumaG-17 tushen kayan gwajin haɗin gwiwa tare da babban hankali da ƙayyadaddun ƙayyadaddun bayanai, waɗanda zasu iya samar da ingantaccen kayan aikin tantancewa don CAG a cikin asibitin. Za mu ci gaba da bin ci gaban bincike a cikin wannan filin da haɓaka aikace-aikacen fassarar ƙarin alamomi masu ƙima.