Alamomin Halitta don Ciwon Gastritis na Atrophic na Kullum: Ci gaban Bincike

Ciwon Gastritis na Atrophic na Kullum (CAG) cuta ce ta yau da kullun da ke shafar narkewar abinci a hankali da kuma raguwar aikin ciki. A matsayin muhimmin mataki na raunukan ciki kafin ciwon daji, gano cutar da wuri da kuma sa ido kan CAG suna da mahimmanci don hana ci gaban ciwon daji na ciki. A cikin wannan takarda, za mu tattauna manyan alamomin da ake amfani da su a yanzu don gano cutar da kuma sa ido kan CAG da kuma darajar amfani da su a asibiti.

I. Alamomin Halittar Jijiyoyin Halitta

1. Pepsinogen (PG)ThePGⅠ/PGⅡ rabo (PGⅠ/PGⅡ) shine alamar serological da aka fi amfani da ita ga CAG.

• Rage matakan PGⅠ da PGⅠ/PGⅡrabon yana da alaƙa sosai da matakin atrophy na jiki na ciki.
• Jagororin Japan da Turai sun haɗa da gwajin PG a cikin shirye-shiryen gwajin cutar kansar ciki

2.Gastrin-17 (G-17)

• Yana nuna yanayin aikin endocrine na sinus na ciki.
• Rage raguwar atrophy na sinus na ciki kuma yana iya ƙaruwa a cikin atrophy na jikin ciki.
• Haɗa tare da PG don inganta daidaiton ganewar cutar CAG

3. Magungunan rigakafi na ƙwayoyin cuta na Anti-Parietal (APCA) da kuma Magungunan rigakafi na Anti-Intrinsic Factor (AIFA)

• Alamomi na musamman don cututtukan gastritis na autoimmune.
• Yana taimakawa wajen bambance cututtukan gastritis na autoimmune daga sauran nau'ikan CAG

2. Alamomin Halittu na Tarihi

1. CDX2 da MUC2
   • Wani sinadari na chemotaxis na hanji
   • Haɓaka aikin hanji yana nuna cewa mucosa na ciki yana shiga cikin hanji.
2. shafi na 53 da Ki-67
   • Alamomin yaduwar ƙwayoyin halitta da kuma bambancin da ba a saba gani ba.
   • Taimaka wajen tantance haɗarin kamuwa da cutar kansa a cikin CAG.
3. Helicobacter pylori (H. pylori)-Alamomin da suka shafi
   • Gano abubuwan da ke haifar da kamuwa da cuta kamar CagA da VacA.
   • Gwajin numfashi na urea (UBT) da gwajin antigen na bayan gida.

3. Alamomin Halittu Masu Fitowa

1. ƙananan RNA
   • miR-21, miR-155 da sauransu suna bayyana a cikin CAG ba daidai ba
   • Ƙimar ganewar asali da kuma hasashen da za a iya samu.
2. Alamun Methylation na DNA
   • Tsarin methylation mara kyau a cikin yankunan masu tallata wasu kwayoyin halitta
   • Matsayin Methylation na kwayoyin halitta kamar CDH1 da RPRM
3. Alamomin Halittar Metabolomic
   • Canje-canje a cikin takamaiman bayanan metabolite suna nuna yanayin mucosa na ciki
   • Sabbin ra'ayoyi don ganewar asali marasa cutarwa

4. Aikace-aikacen Asibiti da Ra'ayoyin Gaba

Gwaje-gwajen da aka haɗa na biomarkers na iya inganta yanayin da kuma takamaiman ganewar cutar CAG. A nan gaba, ana sa ran haɗakar nazarin multi-omics zai samar da cikakken haɗin biomarkers don daidaitaccen rubutu, rarraba haɗari da kuma sa ido kan CAG.

Mu Baysen Medical mun ƙware a fannin bincike da haɓaka magungunan gano cututtuka na tsarin narkewar abinci, kuma mun haɓaka su.PGⅠ, PGⅡ kumaG-17 Kayan gwaji na haɗin gwiwa waɗanda ke da babban hankali da takamaiman aiki, waɗanda za su iya samar da ingantattun kayan aikin tantancewa ga CAG a asibitin. Za mu ci gaba da bin diddigin ci gaban bincike a wannan fanni da kuma haɓaka amfani da fassara na ƙarin alamomi masu ƙirƙira.