Dangantaka Tsakanin Fatty Hanta da Insulin

Dangantaka Tsakanin Fatty Hanta da Insulin Glycated shine kusanci tsakanin hanta mai kitse (musamman cutar hanta mai kitse ba ta barasa ba, NAFLD) dainsulin(koinsulinjuriya, hyperinsulinemia), wanda ake yin sulhu ta farko ta hanyar rikice-rikice na rayuwa (misali, kiba, nau'in 2ciwon sukari,da sauransu). Mai zuwa shine cikakken nazari akan mahimman abubuwan:

1. InsulinJuriya azaman Core Mechanism

• Insulinjuriya (IR) shine tushen cututtukan gama gari don hanta mai kitse da rashin daidaituwa na glucose metabolism. Lokacin da hankalin jiki ga insulin ya ragu, pancreas yana ramawa sosaiinsulin(hyperinsulinemia), wanda ke haifar da haɓakar matakan insulin na jini.
• Sakamakon hanta mai kitse: hantainsulinjuriya yana hana oxidation fatty acid, yana haɓaka haɓakar mai (jigon lipid), kuma yana ƙara haɓakar kitse a cikin hepatocytes (steatosis).
• Ƙungiya daHbA1c: Ko da yake insulin glycated ba alama ce ta asibiti da aka saba amfani da ita ba, hyperglycemia mai tsawo (mai alaƙa da IR) yana ƙara haemoglobin glycated.(HbA1c), yana nuna rashin kula da ciwon sukari na jini, wanda ke hade da ci gaban hanta mai kitse zuwa steatohepatitis mara giya (NASH).

2. Hyperinsulinemia Yana Haɓaka Ciwon Hanta mai Fat

• Ayyukan kai tsaye: Hyperinsulinemia yana haɓaka lipogenesis na hanta (↑ haɗin lipid) ta hanyar kunna abubuwan rubutu (misali SREBP-1c) yayin da ke hana fatty acid β-oxidation.
• Tasirin Kai tsaye:Insulinjuriya yana haifar da ƙwayar adipose don sakin ƙarin fatty acids (FFAs), waɗanda ke shiga hanta kuma suna jujjuya su zuwa triglycerides, yana ƙara tsananta hanta mai kitse.

3. Hanta mai kitse na kara kara kuzarin glucose na al'ada

• Hanta-HantaInsulinJuriya: Hanta mai kitse tana sakin cytokines masu kumburi (misali, TNF-α,IL-6) da adipokines (misali, juriya na leptin, raguwar adiponectin), daɗaɗa juriya na tsarin insulin.
• Ƙara yawan fitowar glucose na hanta:insulinjuriya yana haifar da gazawar hanta don hana gluconeogenesis da kyau, kuma haɓakar glucose na jini na azumi yana ƙara tsananta metabolism na glucose (mai yiwuwa ci gaba zuwa nau'in ciwon sukari na 2).

4. Shaidar asibiti:Glycosylated haemoglobin (HbA1c)da Fatty Hanta

• Haɓaka HbA1c yana annabta haɗarin hanta mai kitse: bincike da yawa sun nuna hakanHbA1cMatakan suna da alaƙa da ingancin hanta mai kitse, koda lokacin da ba a cika ka'idodin gano ciwon sukari ba (haɗarin yana ƙaruwa sosai tare da HbA1c ≥ 5.7%).
• Sarrafa Glycemic a cikin Marasa lafiya Hanta mai Fatty: Marasa lafiya masu ciwon sukari tare da hanta mai kitse na iya buƙatar tsananin sarrafa sukarin jini (ƙananan maƙasudin HbA1c) don rage ci gaban cutar hanta.

5. Dabarun Tsangwama: IngantawaInsulinHankali

• gyare-gyaren salon rayuwa: asarar nauyi (5-10% asarar nauyi yana inganta haɓakar hanta mai kitse), ƙarancin carbohydrate / rage cin abinci mai ƙarancin mai, motsa jiki na motsa jiki.
• Magunguna:
  • Insulinsensitizers (misali, metformin, pioglitazone) na iya inganta hanta mai kitse da glucose metabolism.
  • GLP-1 agonists mai karɓa (misali, liraglutide, semaglutide) yana taimakawa a cikin asarar nauyi, sarrafa glycemic, da rage hanta mai kitse.
• Kulawa: Azumiinsulin, HOMA-IR (ma'anar juriya na insulin), HbA1c da hanta hoto / elastography an gwada su akai-akai.

Kammalawa

Hanta mai kitse da insulin (ko hyperinsulinemia) yana haifar da mummunan zagayowar ta hanyar juriya na insulin. Farkon shiga tsakani nainsulinjuriya yana inganta hanta mai kitse da glucose metabolism kuma yana rage haɗarin ciwon sukari da fibrosis na hanta. Ana buƙatar a tantance alamomin ƙwayar cuta tare a cikin asibiti maimakon mayar da hankali kan mai nuna alama ɗaya kaɗai.

Mu Baysen Medical koyaushe yana mai da hankali kan dabarun bincike don haɓaka ingancin rayuwa. Mun ɓullo da 5 fasaha dandamali- Latex, colloidal zinariya, Fluorescence Immunochromatographic Assay, Kwayoyin, Chemiluminescence Immunoassay, Ourgwajin HbA1c,Gwajin insulinkumaC-peptide gwajin aiki mai sauƙi kuma yana iya samun sakamakon gwaji a cikin mintuna 15