Nā Biomarkers no ka Chronic Atrophic Gastritis: Nā Holomua Noiʻi

ʻO ka Chronic Atrophic Gastritis (CAG) kahi maʻi ʻōpū maʻamau i hōʻike ʻia e ka nalowale mālie o nā kelepa mucosal gastric a me ka emi ʻana o ka hana gastric. Ma ke ʻano he kahua koʻikoʻi o nā ʻeha precancerous gastric, ʻo ka ʻike mua ʻana a me ka nānā ʻana i ka CAG he mea nui ia no ka pale ʻana i ka ulu ʻana o ka maʻi ʻōpū. Ma kēia pepa, e kūkākūkā mākou i nā biomarkers nui o kēia manawa i hoʻohana ʻia e ʻike a nānā i ka CAG a me kā lākou waiwai noi lapaʻau.

I. Nā Māka Biolohiko Serologic

1. ʻO ka Pepsinogen (PG)ʻO kaPGⅠ/PGⅡ lakio (PGⅠ/PGⅡ) ka māka serological i hoʻohana nui ʻia no CAG.

• Ua emi nā pae o ʻO PGⅠ a me PGⅠ/PGⅡua pili pono ka lakio me ke kekelē o ka atrophy o ke kino gastric.
• Ua hoʻokomo nā alakaʻi Kepanī a me ʻEulopa i ka hoʻāʻo ʻana o PG i nā papahana nānā ʻana i ka maʻi ʻōpū

2.ʻO Gastrin-17 (G-17)

• Hōʻike ia i ke kūlana hana endocrine o ka sinus gastric.
• Hoʻemi ʻia ka atrophy o ka sinus gastric a hiki ke hoʻonui ʻia ka atrophy o ke kino gastric.
• Ua hui pū ʻia me PG e hoʻomaikaʻi i ka pololei o ka hōʻailona CAG

3.Nā Antibodies Cell Anti-Parietal (APCA) a me nā Antibodies Factor Anti-Intrinsic (AIFA)

• Nā hōʻailona kikoʻī no ka gastritis autoimmune.
• Kōkua i ka hoʻokaʻawale ʻana i ka gastritis autoimmune mai nā ʻano ʻē aʻe o CAG

2. Nā Biomarkers Histological

1. ʻO CDX2 a me MUC2
   • He molekala hōʻailona o ka chemotaxis ʻōpū
   • ʻO ka hoʻonui ʻia ʻana o ke kaʻina hana e hōʻike i ka hoʻonui ʻia ʻana o ka mucosa gastric.
2. p53 a me Ki-67
   • Nā hōʻailona o ka hoʻonui ʻana o nā cell a me ka hoʻokaʻawale ʻana maʻamau ʻole.
   • Kōkua i ka loiloi ʻana i ka pilikia o ka maʻi kanesa ma CAG.
3. ʻO ka maʻi Helicobacter pylori (H. pylori)-Nā Māka Pili
   • Ka ʻike ʻana i nā mea hoʻouluulu e like me CagA a me VacA.
   • Hoʻāʻo hanu Urea (UBT) a me ka hoʻāʻo antigen stool.

3. Nā Biomarkers Molecular e kū mai ana

1. nā microRNA
   • Ua hōʻike hewa ʻia ʻo miR-21, miR-155 a me nā mea ʻē aʻe ma CAG
   • Ka waiwai hōʻoia a me ka wānana kūpono.
2. Nā Māka Methylation DNA
   • Nā ʻano methylation maʻamau ʻole i nā wahi hoʻolaha o kekahi mau genes
   • Ke kūlana methylation o nā genes e like me CDH1 a me RPRM
3. Nā Biomarkers Metabolomic
   • Hōʻike nā loli i nā ʻano metabolite kikoʻī i ke kūlana o ka mucosa gastric
   • Nā manaʻo hou no nā hōʻailona invasive ʻole

4. Nā Noi Lapaʻau a me nā Manaʻo o ka Wā e Hiki Mai Ana

Hiki i ka hoʻāʻo hui pū ʻana o nā biomarkers ke hoʻomaikaʻi nui i ka ʻike a me ke kikoʻī o ka hōʻailona CAG. I ka wā e hiki mai ana, manaʻo ʻia ka loiloi multi-omics i hoʻohui ʻia e hāʻawi i kahi hui piha o nā biomarkers no ke ʻano kikoʻī, ka hoʻokaʻawale ʻana i ka pilikia a me ka nānā pilikino ʻana o CAG.

He loea mākou ʻo Baysen Medical i ka noiʻi a me ka hoʻomohala ʻana i nā reagents diagnostic no nā maʻi ʻōnaehana digestive, a ua hoʻomohala i nāPGⅠ, PGⅡ a meG-17 nā pahu hoʻāʻo like me ka ʻike kiʻekiʻe a me ke kikoʻī, hiki ke hāʻawi i nā mea hana loiloi hilinaʻi no CAG ma ke keʻena lapaʻau. E hoʻomau mākou i ka hahai ʻana i ka holomua o ka noiʻi ma kēia kahua a paipai i ka hoʻohana unuhi ʻana o nā māka hou aʻe.