Biomarkers no Chronic Atrophic Gastritis: Noiʻi holomua

ʻO Chronic Atrophic Gastritis (CAG) kahi maʻi maʻamau maʻamau i hōʻike ʻia e ka nalo mālie ʻana o nā ʻōpū mucosal ʻōpū a me ka emi ʻana o ka hana ʻōpū. Ma ke ʻano he kūlana koʻikoʻi o nā maʻi maʻi precancerous ʻōpū, he mea koʻikoʻi ka ʻike mua a me ka nānā ʻana o CAG no ka pale ʻana i ka ulu ʻana o ka maʻi maʻi ʻōpū. Ma kēia pepa, e kūkākūkā mākou i nā biomarkers nui o kēia manawa i hoʻohana ʻia e ʻike a nānā i ka CAG a me kā lākou waiwai noi noi.

I. Serologic BioMarkers

1. Pepsinogen (PG)ʻO kaPGⅠ/PGⅡ ratio (PGⅠ/PGⅡ) ʻo ia ka māka serologic i hoʻohana nui ʻia no CAG.

• Ua emi ka pae o PGⅠ a me PGⅠ/PGⅡpili pono ka ratio me ke kiʻekiʻe o ka atrophy kino o ka ʻōpū.
• Ua hoʻokomo ʻia nā alakaʻi alakaʻi Iapana a me ʻEulopa i ka hoʻāʻo ʻana i ka PG i nā papahana screening cancer

2.Gastrin-17 (G-17)

• Hōʻike i ke kūlana hana endocrine o ka ʻōpū ʻōpū.
• Hoʻemi i ka atrophy o ka ʻōpū ʻōpū a hiki ke hoʻonui i ka atrophy o ke kino ʻōpū.
• Hoʻohui ʻia me PG e hoʻomaikaʻi i ka pololei diagnostic CAG

3. Anti-Parietal Cell Antibodies (APCA) a me Anti-Intrinsic Factor Antibodies (AIFA)

• Nā hōʻailona kikoʻī no ka autoimmune gastritis.
• Kōkua i ka hoʻokaʻawale ʻana i ka maʻi maʻi autoimmune mai nā ʻano CAG ʻē aʻe

2. Nā Hōʻailona Biomarkers

1. CDX2 a me MUC2
   • He mole mole o ka chemotaxis intestinal
   • Hōʻike ka upregulation i ka ʻōpū o ka ʻōpū mucosal.
2. p53 a me Ki-67
   • Nā hōʻailona o ka hoʻonui ʻana o ke kelepona a me ka ʻokoʻa like ʻole.
   • Kōkua i ka loiloi i ka pilikia maʻi maʻi ma CAG.
3. Helicobacter pylori (H. pylori)-Na Hoailona Pili
   • Ka ʻike ʻana i nā mea virulence e like me CagA a me VacA.
   • ʻO ka ho'āʻo hanu Urea (UBT) a me ka ho'āʻo antigen stool.

3. ʻO nā mea hōʻailona Molecular e puka mai ana

1. microRNAs
   • ʻO miR-21, miR-155 a me nā mea ʻē aʻe i hōʻike ʻia ma CAG
   • Ka waiwai diagnostic a me prognostic waiwai.
2. DNA Methylation Markers
   • Nā hiʻohiʻona methylation maʻamau i nā wahi hoʻolaha o kekahi mau genes
   • ʻO ke kūlana methylation o nā genes e like me CDH1 a me RPRM
3. Metabolomic Biomarkers
   • Hōʻike ka hoʻololi ʻana i nā profile metabolite kikoʻī i ke kūlana o ka mucosa ʻōpū
   • Nā manaʻo hou no nā diagnostics non-invasive

4. Nā noi lāʻau lapaʻau a me nā manaʻo e hiki mai ana

ʻO ka hoʻāʻo ʻana o nā biomarkers hiki ke hoʻomaikaʻi nui i ka naʻau a me ka kikoʻī o ka maʻi CAG. I ka wā e hiki mai ana, manaʻo ʻia ka loiloi multi-omics i hoʻohui ʻia e hāʻawi i kahi hui piha o nā biomarkers no ka paʻi pololei ʻana, ka stratification pilikia a me ka nānā ʻana o ka CAG.

Mākou Baysen Lapaʻau kūikawā i ka noiʻi a me ka hooulu ana o diagnostic reagents no ka digestive system maʻi, a ua uluPGⅠ, PGⅡ aG-17 nā pahu ho'āʻo hoʻohālikelike kiʻekiʻe me ka ʻike kiʻekiʻe a me ka kikoʻī, hiki ke hāʻawi i nā hāmeʻa nānā pono no CAG ma ke keʻena. E hoʻomau mākou i ka hahai ʻana i ka holomua noiʻi ma kēia kahua a paipai i ka hoʻohana unuhi ʻana o nā māka hou aʻe.