Biomarkers rau Chronic Atrophic Gastritis: Kev Tshawb Fawb Ua Ntej

Chronic Atrophic Gastritis (CAG) yog ib hom kab mob plab hnyuv loj uas tshwm sim los ntawm kev poob ntawm cov qog nqaij hlav hauv plab thiab txo qis hauv plab. Raws li ib qho tseem ceeb ntawm cov kab mob plab precancerous, kev kuaj mob ntxov thiab kev saib xyuas ntawm CAG yog qhov tseem ceeb rau kev tiv thaiv kev loj hlob ntawm plab hnyuv. Hauv daim ntawv no, peb yuav tham txog cov biomarkers tseem ceeb tam sim no siv los kuaj xyuas thiab saib xyuas CAG thiab lawv cov nqi kho mob.

I. Serologic BioMarkers

1. Pepsinogen (PG)CovPGⅠ/PGⅡ piv (PGⅠ/PGⅡ) yog qhov siv ntau tshaj plaws serologic marker rau CAG.

• Txo qib ntawm PGⅠ thiab PGⅠ/PGⅡQhov sib piv yog sib cuam tshuam nrog cov degree ntawm gastric lub cev atrophy.
• Nyiv thiab European cov lus qhia tau suav nrog PG kuaj hauv cov kev kuaj mob plab hnyuv

2.Gastrin-17 (G-17)

• Reflects endocrine functional xwm txheej ntawm gastric sinus.
• Kev txo qis hauv atrophy ntawm gastric sinus thiab tuaj yeem ua rau atrophy ntawm lub plab zom mov.
• Ua ke nrog PG txhawm rau txhim kho CAG kuaj qhov tseeb

3.Anti-Parietal Cell Antibodies (APCA) thiab Anti-Intrinsic Factor Antibodies (AIFA)

• Cov cim tshwj xeeb rau autoimmune gastritis.
• Pab kom sib txawv autoimmune gastritis los ntawm lwm hom CAG

2. Histological Biomarkers

1. CDX2 thiab MUC2
   • Ib qho kos npe molecule ntawm plab hnyuv chemotaxis
   • Upregulation qhia tias gastric mucosal plab hnyuv.
2. p53i67 ua
   • Indicators ntawm cell proliferation thiab txawv txawv txawv.
   • Pab ntsuas kev pheej hmoo mob qog noj ntshav hauv CAG.
3. Helicobacter pylori (H. pylori)-Cov cim txheeb
   • Kev txheeb xyuas cov xwm txheej virulence xws li CagA thiab VacA.
   • Urea breath test (UBT) thiab quav tshuaj antigen.

3. Emerging Molecular Biomarkers

1. microRNAs
   • miR-21, miR-155 thiab lwm yam tau hais tawm tsis zoo hauv CAG
   • Muaj peev xwm kuaj mob thiab tus nqi prognostic.
2. DNA Methylation Markers
   • Cov qauv methylation txawv txav hauv thaj chaw txhawb nqa ntawm qee cov noob
   • Methylation txheej xwm ntawm cov noob xws li CDH1 thiab RPRM
3. Metabolomic Biomarkers
   • Cov kev hloov pauv hauv cov metabolite tshwj xeeb qhia txog lub xeev ntawm lub plab mucosa
   • Cov tswv yim tshiab rau kev kuaj mob tsis muaj kev cuam tshuam

4. Kev siv tshuaj kho mob thiab kev pom yav tom ntej

Kev sim ua ke ntawm biomarkers tuaj yeem txhim kho qhov rhiab heev thiab tshwj xeeb ntawm CAG kuaj mob. Nyob rau hauv lub neej yav tom ntej, kev sib koom ua ke ntau-omics tsom xam yuav tsum muab kev sib xyaw ua ke ntawm biomarkers rau kev ntaus ntawv, kev pheej hmoo stratification thiab kev saib xyuas tus kheej ntawm CAG.

Peb Baysen Medical tshwj xeeb hauv kev tshawb fawb thiab kev tsim kho cov tshuaj tiv thaiv kab mob rau cov kab mob hauv plab, thiab tau tsimPGⅠ, PGⅡ thiabG-17 raws li cov khoom siv sib koom ua ke nrog cov rhiab heev thiab tshwj xeeb, uas tuaj yeem muab cov cuab yeej tshuaj ntsuam xyuas zoo rau CAG hauv tsev kho mob. Peb yuav txuas ntxiv ua raws li kev tshawb fawb tau ua tiav hauv daim teb no thiab txhawb nqa cov ntawv txhais lus ntawm cov cim tshiab.