Cov cim qhia txog kab mob Gastritis ntev: Kev tshawb fawb nce qib

Kab mob plab hnyuv loj (CAG) yog ib yam kab mob plab uas feem ntau tshwm sim los ntawm kev poob qis ntawm cov qog ntawm lub plab thiab ua rau lub plab tsis ua haujlwm zoo. Ua ib theem tseem ceeb ntawm cov qog ua ntej mob qog noj ntshav hauv plab, kev kuaj mob thaum ntxov thiab kev saib xyuas CAG yog qhov tseem ceeb rau kev tiv thaiv kev loj hlob ntawm mob qog noj ntshav hauv plab. Hauv tsab ntawv no, peb yuav tham txog cov cim qhia tseem ceeb uas siv los kuaj mob thiab saib xyuas CAG thiab lawv cov txiaj ntsig kev siv kho mob.

I. Cov Cim Qhia Txog Kab Mob Serologic

1. Pepsinogen (PG)LubPGⅠ/PGⅡ piv (PGⅠ/PGⅡ) yog cov cim qhia txog CAG uas siv dav tshaj plaws.

• Cov theem txo qis ntawm PGⅠ thiab PGⅠ/PGⅡqhov sib piv muaj feem cuam tshuam nrog qib ntawm lub cev atrophy.
• Cov lus qhia ntawm Nyiv Pooj thiab Tebchaws Europe tau suav nrog kev kuaj PG hauv cov kev pab cuam kuaj mob qog noj ntshav hauv plab.

2.Gastrin-17 (G-17)

• Qhia txog qhov xwm txheej ntawm kev ua haujlwm ntawm endocrine ntawm lub plab sinus.
• Txo qhov atrophy ntawm lub gastric sinus thiab tej zaum yuav ua rau lub cev gastric atrophy ntau ntxiv.
• Ua ke nrog PG los txhim kho qhov tseeb ntawm kev kuaj mob CAG

3. Cov Tshuaj Tiv Thaiv Kab Mob Parietal Cell (APCA) thiab Cov Tshuaj Tiv Thaiv Kab Mob Intrinsic Factor (AIFA)

• Cov cim qhia tshwj xeeb rau autoimmune gastritis.
• Pab tau rau kev sib txawv ntawm autoimmune gastritis los ntawm lwm hom CAG

2. Cov cim qhia txog keeb kwm ntawm cov kab mob

1. CDX2 thiab MUC2
   • Ib qho cim qhia ntawm cov chemotaxis hauv plab hnyuv
   • Kev nce ntxiv ntawm cov piam thaj qhia tias mucous membrane ntawm lub plab zom mov.
2. p53 thiab Ki-67
   • Cov cim qhia txog kev loj hlob ntawm cov cell thiab kev sib txawv tsis zoo.
   • Pab ntsuam xyuas qhov muaj feem yuav mob qog noj ntshav hauv CAG.
3. Kab mob Helicobacter pylori (H. pylori)-Cov Cim Cuam Tshuam
   • Kev kuaj pom cov yam ntxwv virulence xws li CagA thiab VacA.
   • Kev kuaj ua pa Urea (UBT) thiab kev kuaj antigen hauv cov quav.

3. Cov cim qhia txog cov tshuaj lom neeg tshiab

1. Cov microRNAs
   • miR-21, miR-155 thiab lwm yam tau qhia tawm txawv txawv hauv CAG
   • Muaj peev xwm kuaj mob thiab kwv yees tau tus nqi.
2. Cov Cim Qhia Txog DNA Methylation
   • Cov qauv methylation tsis zoo hauv thaj chaw txhawb nqa ntawm qee cov noob caj noob ces
   • Cov xwm txheej methylation ntawm cov noob xws li CDH1 thiab RPRM
3. Cov cim qhia txog kev hloov pauv hauv lub cev
   • Cov kev hloov pauv hauv cov qauv metabolite tshwj xeeb qhia txog qhov xwm txheej ntawm lub plab zom mov
   • Cov tswv yim tshiab rau kev kuaj mob tsis muaj kev phais

4. Cov Kev Siv Hauv Kev Kho Mob thiab Kev Xav Txog Yav Tom Ntej

Kev kuaj ua ke ntawm cov cim qhia txog kab mob (biomarkers) tuaj yeem txhim kho qhov rhiab heev thiab qhov tshwj xeeb ntawm kev kuaj mob CAG. Yav tom ntej, kev tshuaj xyuas ntau yam kev sib xyaw ua ke yuav muab kev sib xyaw ua ke ntawm cov cim qhia txog kab mob (biomarkers) kom meej dua rau kev ntaus ntawv kom raug, kev faib cov kev pheej hmoo thiab kev saib xyuas tus kheej ntawm CAG.

Peb Baysen Medical tshwj xeeb hauv kev tshawb fawb thiab kev txhim kho cov tshuaj reagents kuaj mob rau cov kab mob hauv lub plab, thiab tau tsimPGⅠ, PGⅡ thiabG-17 cov khoom siv kuaj mob ua ke uas muaj kev rhiab heev thiab tshwj xeeb, uas tuaj yeem muab cov cuab yeej tshuaj ntsuam xyuas zoo rau CAG hauv chaw kho mob. Peb yuav txuas ntxiv ua raws li kev tshawb fawb hauv daim teb no thiab txhawb kev siv cov cim tshiab dua.